High-dose intravenous vitamin C decreases rates of mechanical ventilation and cardiac arrest in severe COVID-19

DOI record: { "DOI": "10.1007/s11739-022-02954-6", "ISSN": [ "1828-0447", "1970-9366" ], "URL": "http://dx.doi.org/10.1007/s11739-022-02954-6", "alternative-id": [ "2954" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "30 March 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "22 February 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "29 March 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The authors have no competing interests to declare." }, { "group": { "label": "Human and animal rights statement", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "This study as approved by the Institutional Review Board, Beaumont Health." }, { "group": { "label": "Informed consent", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "Informed consent was waived as the curent study was had a retrospective design." }, { "label": "Free to read", "name": "free", "value": "This content has been made available to all." } ], "author": [ { "affiliation": [], "family": "Hess", "given": "Andrea L.", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-1805-992X", "affiliation": [], "authenticated-orcid": false, "family": "Halalau", "given": "Alexandra", "sequence": "additional" }, { "affiliation": [], "family": "Dokter", "given": "Jonathan J.", "sequence": "additional" }, { "affiliation": [], "family": "Paydawy", "given": "Tania S.", "sequence": "additional" }, { "affiliation": [], "family": "Karabon", "given": "Patrick", "sequence": "additional" }, { "affiliation": [], "family": "Bastani", "given": "Aveh", "sequence": "additional" }, { "affiliation": [], "family": "Baker", "given": "Rebecca E.", "sequence": "additional" }, { "affiliation": [], "family": "Balla", "given": "Abdalla Kara", "sequence": "additional" }, { "affiliation": [], "family": "Galens", "given": "Stephen A.", "sequence": "additional" } ], "container-title": [ "Internal and Emergency Medicine" ], "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 3, 29 ] ], "date-time": "2022-03-29T09:30:36Z", "timestamp": 1648546236000 }, "deposited": { "date-parts": [ [ 2022, 3, 29 ] ], "date-time": "2022-03-29T12:01:27Z", "timestamp": 1648555287000 }, "indexed": { "date-parts": [ [ 2022, 3, 30 ] ], "date-time": "2022-03-30T04:47:31Z", "timestamp": 1648615651880 }, "is-referenced-by-count": 0, "issn-type": [ { "type": "print", "value": "1828-0447" }, { "type": "electronic", "value": "1970-9366" } ], "issued": { "date-parts": [ [ 2022, 3, 29 ] ] }, "language": "en", "license": [ { "URL": "https://www.springer.com/tdm", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 29 ] ], "date-time": "2022-03-29T00:00:00Z", "timestamp": 1648512000000 } }, { "URL": "https://www.springer.com/tdm", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 29 ] ], "date-time": "2022-03-29T00:00:00Z", "timestamp": 1648512000000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1007/s11739-022-02954-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1007/s11739-022-02954-6/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1007/s11739-022-02954-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1007", "published": { "date-parts": [ [ 2022, 3, 29 ] ] }, "published-online": { "date-parts": [ [ 2022, 3, 29 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "key": "2954_CR1", "unstructured": "https://coronavirus.jhu.edu/map.html" }, { "DOI": "10.1056/NEJMoa2007764", "author": "JH Beigel", "doi-asserted-by": "publisher", "first-page": "1813", "journal-title": "N Engl J Med", "key": "2954_CR2", "unstructured": "Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Leutkemeyer A (2020) Remdesivir for the treatment of Covid-19—final report. N Engl J Med 383:1813–1826. https://doi.org/10.1056/NEJMoa2007764", "volume": "383", "year": "2020" }, { "DOI": "10.5694/mja2.50674", "author": "PG Gibson", "doi-asserted-by": "publisher", "first-page": "54", "journal-title": "Med J Aust", "key": "2954_CR3", "unstructured": "Gibson PG, Qin L, Puah SH (2020) COVID-19 acute respiratory distress syndrome (ARDS): clinical features and differences from typical pre- COVID-19 ARDS. Med J Aust 213:54–56. https://doi.org/10.5694/mja2.50674", "volume": "213", "year": "2020" }, { "DOI": "10.1186/s13054-017-1891-y", "author": "AC Carr", "doi-asserted-by": "publisher", "first-page": "300", "journal-title": "Crit Care", "key": "2954_CR4", "unstructured": "Carr AC, Rosengrave P, Bayer S, Chambers S, Mehrtens J, Shaw GM (2017) Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care 21:300", "volume": "21", "year": "2017" }, { "DOI": "10.1001/jama.2019.11825", "author": "AA Fowler", "doi-asserted-by": "publisher", "first-page": "1261", "journal-title": "JAMA", "key": "2954_CR5", "unstructured": "Fowler AA, Truwit JD, Hite RD (2019) Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA 322:1261–1270. https://doi.org/10.1001/jama.2019.11825", "volume": "322", "year": "2019" }, { "DOI": "10.1016/j.jgar.2020.09.025", "author": "BX Hoang", "doi-asserted-by": "publisher", "first-page": "256", "journal-title": "J Glob Antimicrob Resist", "key": "2954_CR6", "unstructured": "Hoang BX, Show G, Fang W, Han B (2020) Possible application of high-dose vitamin C in the prevention and therapy of coronavirus infection. J Glob Antimicrob Resist 23:256–262. https://doi.org/10.1016/j.jgar.2020.09.025", "volume": "23", "year": "2020" }, { "DOI": "10.3390/nu12020292", "author": "MG Kashiouris", "doi-asserted-by": "publisher", "first-page": "292", "issue": "2", "journal-title": "Nutrients", "key": "2954_CR7", "unstructured": "Kashiouris MG, L’Heureux M, Cable CA, Fisher BJ, Leichtle SA, Fowler AA (2020) The emerging role of vitamin C as a treatment for sepsis. Nutrients 12(2):292. https://doi.org/10.3390/nu12020292", "volume": "12", "year": "2020" }, { "DOI": "10.1016/j.chest.2016.11.036", "author": "PE Mark", "doi-asserted-by": "publisher", "first-page": "1229", "issue": "6", "journal-title": "Chest", "key": "2954_CR8", "unstructured": "Mark PE, Khangoora V, Rivera R, Hooper MH, Catravas J (2017) Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock. Chest 151(6):1229–1238. https://doi.org/10.1016/j.chest.2016.11.036", "volume": "151", "year": "2017" }, { "key": "2954_CR9", "unstructured": "Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia (n.d.). ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04264533" }, { "DOI": "10.1186/s13613-020-00792-3", "author": "J Zhang", "doi-asserted-by": "publisher", "first-page": "5", "journal-title": "Ann Intensive Care", "key": "2954_CR10", "unstructured": "Zhang J, Rao X, Li Y et al (2021) Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care 11:5. https://doi.org/10.1186/s13613-020-00792-3", "volume": "11", "year": "2021" }, { "key": "2954_CR11", "unstructured": "Bhimraj A, Morgan RL, Shumaker AH, Lavergne V, Baden L, Cheng VC, Edwards KM, Gandhi R, Gallaghe, Muller WJ, O’Horo JC, Shoham S, Murad MH, Mustafa RA, Sultan S, Falck-Ytter Y (2020) Guidelines on the treatment and management of patients with COVID-19. Inf Dis Soc Am. https://www.idsociety.org/COVID19guidelines" }, { "DOI": "10.1038/s41591-020-0822-7", "author": "JT Wu", "doi-asserted-by": "publisher", "first-page": "506", "journal-title": "Nat Med", "key": "2954_CR12", "unstructured": "Wu JT, Leung K, Bushman M et al (2020) Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. Nat Med 26:506–510. https://doi.org/10.1038/s41591-020-0822-7", "volume": "26", "year": "2020" }, { "DOI": "10.1016/0021-9681(87)90171-8", "author": "ME Charlson", "doi-asserted-by": "publisher", "first-page": "373", "issue": "5", "journal-title": "J Chronic Dis", "key": "2954_CR13", "unstructured": "Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383. https://doi.org/10.1016/0021-9681(87)90171-8 (PMID: 3558716)", "volume": "40", "year": "1987" }, { "DOI": "10.1186/cc5713", "author": "RL Mehta", "doi-asserted-by": "publisher", "first-page": "31", "issue": "2", "journal-title": "Crit Care", "key": "2954_CR14", "unstructured": "Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):31. https://doi.org/10.1186/cc5713 (PMID: 17331245; PMCID: PMC2206446)", "volume": "11", "year": "2007" }, { "DOI": "10.1016/j.chest.2018.02.025", "author": "HJ de Grooth", "doi-asserted-by": "publisher", "first-page": "1368", "issue": "6", "journal-title": "Chest", "key": "2954_CR15", "unstructured": "de Grooth HJ, Manubulu-Choo WP, Zandvliet AS, Spoelstra-de Man AME, Girbes AR et al (2018) Vitamin c pharmacokinetics in critically Ill patients: a randomized trial of four IV regimens. Chest 153(6):1368–1377", "volume": "153", "year": "2018" }, { "DOI": "10.1186/s40560-020-0432-y", "author": "H Hemilä", "doi-asserted-by": "publisher", "first-page": "15", "issue": "8", "journal-title": "J Intensive Care", "key": "2954_CR16", "unstructured": "Hemilä H, Chalker E (2020) Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis. J Intensive Care 7(8):15. https://doi.org/10.1186/s40560-020-0432-y (PMID: 32047636; PMCID: PMC7006137)", "volume": "7", "year": "2020" }, { "DOI": "10.3390/nu12123760", "author": "P Holford", "doi-asserted-by": "publisher", "first-page": "3760", "issue": "12", "journal-title": "Nutrients", "key": "2954_CR17", "unstructured": "Holford P, Carr AC, Jovic TH, Ali SR, Whitaker IS, Marik PE, Smith AD (2020) Vitamin C—an adjunctive therapy for respiratory infection, sepsis and COVID-19. Nutrients 12(12):3760", "volume": "12", "year": "2020" }, { "DOI": "10.1016/j.ekir.2020.07.008", "author": "F Fontana", "doi-asserted-by": "publisher", "first-page": "1815", "issue": "10", "journal-title": "Kidney Int Rep", "key": "2954_CR18", "unstructured": "Fontana F et al (2020) oxalate nephropathy caused by excessive vitamin C administration in 2 patients with COVID-19. Kidney Int Rep 5(10):1815–1822", "volume": "5", "year": "2020" }, { "DOI": "10.29390/cjrt-2018-016", "author": "JI Keddissi", "doi-asserted-by": "publisher", "first-page": "1", "journal-title": "Can J Respir Ther", "key": "2954_CR19", "unstructured": "Keddissi JI, Youness HA, Jones KR, Kinasewitz GT (2018) Fluid management in acute respiratory distress syndrome: a narrative review. Can J Respir Ther 55:1–8. https://doi.org/10.29390/cjrt-2018-016", "volume": "55", "year": "2018" }, { "DOI": "10.21037/apm-20-1387", "doi-asserted-by": "publisher", "key": "2954_CR20", "unstructured": "Zhao B, Ling Y, Li J, Peng Y, Huang J, Wang Y, Qu H, Gao Y, Li Y, Hu B, Lu S, Lu H, Zhang W, Mao E (2020) Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study. Ann Palliat Med. https://doi.org/10.21037/apm-20-1387. Epub ahead of print. PMID: 33222462" }, { "DOI": "10.1080/14787210.2020.1794819", "author": "R Hiedra", "doi-asserted-by": "publisher", "first-page": "1259", "issue": "12", "journal-title": "Expert Rev Anti Infect Ther", "key": "2954_CR21", "unstructured": "Hiedra R, Lo KB, Elbashabsheh M et al (2020) The use of IV vitamin C for patients with COVID-19: a case series. Expert Rev Anti Infect Ther 18(12):1259–1261. https://doi.org/10.1080/14787210.2020.1794819", "volume": "18", "year": "2020" }, { "DOI": "10.3390/nu12113286", "author": "AC Carr", "doi-asserted-by": "publisher", "first-page": "3286", "issue": "11", "journal-title": "Nutrients", "key": "2954_CR22", "unstructured": "Carr AC, Rowe S (2020) The emerging role of vitamin C in the prevention and treatment of COVID-19. Nutrients 12(11):3286. https://doi.org/10.3390/nu12113286 (PMID: 33121019; PMCID: PMC7693980)", "volume": "12", "year": "2020" } ], "reference-count": 22, "references-count": 22, "relation": {}, "resource": { "primary": { "URL": "https://link.springer.com/10.1007/s11739-022-02954-6" } }, "score": 1, "short-container-title": [ "Intern Emerg Med" ], "short-title": [], "source": "Crossref", "subject": [ "Emergency Medicine", "Internal Medicine" ], "subtitle": [], "title": [ "High-dose intravenous vitamin C decreases rates of mechanical ventilation and cardiac arrest in severe COVID-19" ], "type": "journal-article", "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy" }