Retrospective 323 hospitalized patients, 153 treated with vitamin C, showing no significant differences. Patients in each group were in different time periods, with the vitamin C group first. Time based confounding is possible due to improvements in SOC.
Although the 21% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality [10‑29%]
from meta analysis of the 38 mortality results to date
This is the 25th of 64 COVID-19 controlled studies
for vitamin C, which collectively show efficacy with p=0.00000022
. 17 studies are RCTs
, which show efficacy with p=0.00000014
This study is excluded in the after exclusion results of meta
substantial confounding by time
likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
risk of death, 21.3% lower, RR 0.79, p = 0.52, treatment 17 of 153 (11.1%), control 24 of 170 (14.1%), NNT 33.
risk of ICU admission, 1.9% higher, RR 1.02, p = 1.00, treatment 11 of 153 (7.2%), control 12 of 170 (7.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Suna et al., 11 May 2021, retrospective, Turkey, peer-reviewed, 5 authors.
Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia
Medicina Clínica, doi:10.1016/j.medcli.2021.04.010
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Conflict of interest The authors declare that they have no conflict of interest.
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