Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia
et al., Med. Clin. (Barc.), doi:10.1016/j.medcli.2021.04.010, May 2021
Vitamin C for COVID-19
6th treatment shown to reduce risk in
September 2020, now with p = 0.00000002 from 75 studies, recognized in 22 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,200+ studies for
200+ treatments. c19early.org
|
Retrospective 323 hospitalized patients, 153 treated with vitamin C, showing no significant differences. Patients in each group were in different time periods, with the vitamin C group first. Time based confounding is possible due to improvements in SOC.
Although the 21% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality [10‑28%] from meta analysis of the 46 mortality results to date.
This is the 25th of 75 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000002 (1 in 50 million).
21 studies are RCTs, which show efficacy with p=0.0012.
This study is excluded in the after exclusion results of meta
analysis:
substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
|
risk of death, 21.3% lower, RR 0.79, p = 0.52, treatment 17 of 153 (11.1%), control 24 of 170 (14.1%), NNT 33.
|
|
risk of ICU admission, 1.9% higher, RR 1.02, p = 1.00, treatment 11 of 153 (7.2%), control 12 of 170 (7.1%).
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Suna et al., 11 May 2021, retrospective, Turkey, peer-reviewed, 5 authors, dosage 2000mg daily.
Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia
Medicina Clínica, doi:10.1016/j.medcli.2021.04.010
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Conflict of interest The authors declare that they have no conflict of interest.
References
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Cheng, Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?, Med Drug Discov, doi:10.1016/j.medidd.2020.100028
Fijen, Weijmer, Acute oxalate nephropathy due to high vitamin C doses and exocrine pancreatic insufficiency, BMJ Case Rep, doi:10.7326/0003-4819-82-6-810_1
Fowler, Truwit, Hite, Morris, Dewilde, Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial, JAMA, doi:10.1016/j.chest.2016.11.036
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