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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 21% Improvement Relative Risk ICU admission -2% Vitamin C for COVID-19  Suna et al.  LATE TREATMENT Is late treatment with vitamin C beneficial for COVID-19? Retrospective 323 patients in Turkey Lower mortality with vitamin C (not stat. sig., p=0.52) Suna et al., Med. Clin., May 2021 Favors vitamin C Favors control

Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia

Suna et al., Med. Clin. (Barc.), doi:10.1016/j.medcli.2021.04.010
May 2021  
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Retrospective 323 hospitalized patients, 153 treated with vitamin C, showing no significant differences. Patients in each group were in different time periods, with the vitamin C group first. Time based confounding is possible due to improvements in SOC.
Although the 21% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality [10‑29%] from meta analysis of the 38 mortality results to date.
This is the 25th of 64 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000022. 17 studies are RCTs, which show efficacy with p=0.00000014. This study is excluded in the after exclusion results of meta analysis: substantial confounding by time likely due to declining usage over the early stages of the pandemic when overall treatment protocols improved dramatically.
risk of death, 21.3% lower, RR 0.79, p = 0.52, treatment 17 of 153 (11.1%), control 24 of 170 (14.1%), NNT 33.
risk of ICU admission, 1.9% higher, RR 1.02, p = 1.00, treatment 11 of 153 (7.2%), control 12 of 170 (7.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Suna et al., 11 May 2021, retrospective, Turkey, peer-reviewed, 5 authors.
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This PaperVitamin CAll
Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia
Uzel S ¸ ener Kavurgacı Suna, Uzel Şener Melahat, Yıldız Murat, Öztürk Ergür Figen, Öztürk Ayperi
Medicina Clínica, doi:10.1016/j.medcli.2021.04.010
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Conflict of interest The authors declare that they have no conflict of interest.
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Late treatment
is less effective
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