Izzo: Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study

Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study

Izzo et al., Pharmacological Research, doi:10.1016/j.phrs.2022.106360

Izzo et al., Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study, Pharmacological Research, doi:10.1016/j.phrs.2022.106360

Jul 2022 Source PDF

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Long COVID trial comparing L-arginine + vitamin C with multivitamin treatment (vitamin B1, B2, B6, B12, nicotinamide, folic acid, pantothenic acid), showing significant improvement in symptoms with L-arginine + vitamin C treatment.

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relative recovery, 41.4% better, RR 0.59, p < 0.001, treatment mean 8.15 (±1.3) n=869, control mean 13.9 (±2.3) n=521, relative symptom score.

relative recovery, 67.5% better, RR 0.33, p < 0.001, treatment 869, control 521, relative Borg score.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Izzo et al., 19 Jul 2022, prospective, Italy, peer-reviewed, 21 authors, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with L-arginine) - results of individual treatments may vary.

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Abstract: Journal Pre-proof Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study Raffaele Izzo, Valentina Trimarco, Pasquale Mone, Teresita Aloè, Massimo Capra Marzani, Antonio Diana, Giovanni Fazio, Mario Mallardo, Mauro Maniscalco, Giuseppe Marazzi, Nunzia Messina, Simone Mininni, Chiara Mussi, Girolamo Pelaia, Alfio Pennisi, Pierachille Santus, Francesco Scarpelli, Francesco Tursi, Alessandro Zanforlin, Gaetano Santulli, Bruno Trimarco PII: S1043-6618(22)00305-X DOI: https://doi.org/10.1016/j.phrs.2022.106360 Reference: YPHRS106360 To appear in: Pharmacological Research Received date: 10 June 2022 Revised date: 17 July 2022 Accepted date: 18 July 2022 Please cite this article as: Raffaele Izzo, Valentina Trimarco, Pasquale Mone, Teresita Aloè, Massimo Capra Marzani, Antonio Diana, Giovanni Fazio, Mario Mallardo, Mauro Maniscalco, Giuseppe Marazzi, Nunzia Messina, Simone Mininni, Chiara Mussi, Girolamo Pelaia, Alfio Pennisi, Pierachille Santus, Francesco Scarpelli, Francesco Tursi, Alessandro Zanforlin, Gaetano Santulli and Bruno Trimarco, Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study,Pharmacological Research, (2022) doi:https://doi.org/10.1016/j.phrs.2022.106360 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier. Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study Raffaele Izzoa1, Valentina Trimarcob,1, Pasquale Monec, Teresita Aloèd, Massimo Capra Marzanie, Antonio Dianaf, Giovanni Faziog, Mario Mallardoh, Mauro Maniscalcoi, Giuseppe Marazzij,, Nunzia Messinak, Simone Mininnil, Chiara Mussim, Girolamo Pelaian, Alfio Pennisio, Pierachille Santusp, Francesco Scarpelliq, Francesco Tursir, Alessandro Zanforlins, Gaetano Santullit*, Bruno of Trimarcoa ro a: Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy -p b: Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University, Naples, Italy lP d: San Martino Hospital, Genoa, Italy re c: Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA e: Alessandria Hospital, Alessandria, Italy rn a f: Aversa Hospital, Aversa, Caserta, Italy i: Palermo Hospital, Palermo, Italy Jo u j: “San Gennaro” Hospital, Naples, Italy k: Istituti Clinici Scientifici Maugeri IRCCS, Telese Terme, Italy l: San Raffaele Hospital, Rome, Italy m: ASL Napoli 1, Naples, Italy 12: Associazione Scientifica Interdisciplinare Aggiornamento Medico (ASIAM), Florence, Italy n: Department of Biomedical and Metabolic Sciences and Neuroscience, University of Modena and Reggio Emilia, Modena, Italy o: Department of Health Science, Magna Graecia University, Catanzaro, Italy 1 Share first authorship p: Catania Hospital, Catania, Italy q: “Luigi Sacco” University Hospital, Milan, Italy r: Trani Hospital, Trani (BT), Italy s:..

Late treatment
is less effective

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