Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study
Izzo et al.,
Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study,
Pharmacological Research, doi:10.1016/j.phrs.2022.106360
Long COVID trial comparing L-arginine + vitamin C with multivitamin treatment (vitamin B1, B2, B6, B12, nicotinamide, folic acid, pantothenic acid), showing significant improvement in symptoms with L-arginine + vitamin C treatment.
relative recovery, 41.4% better, RR 0.59, p < 0.001, treatment mean 8.15 (±1.3) n=869, control mean 13.9 (±2.3) n=521, relative symptom score.
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relative recovery, 67.5% better, RR 0.33, p < 0.001, treatment 869, control 521, relative Borg score.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Izzo et al., 19 Jul 2022, prospective, Italy, peer-reviewed, 21 authors, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with L-arginine) - results of individual treatments may vary.
Abstract: Journal Pre-proof
Combining L-Arginine with Vitamin C Improves
Long-COVID Symptoms: The Nationwide
Multicenter LINCOLN Study
Raffaele Izzo, Valentina Trimarco, Pasquale Mone,
Teresita Aloè, Massimo Capra Marzani, Antonio
Diana, Giovanni Fazio, Mario Mallardo, Mauro
Maniscalco, Giuseppe Marazzi, Nunzia Messina,
Simone Mininni, Chiara Mussi, Girolamo Pelaia,
Alfio Pennisi, Pierachille Santus, Francesco
Scarpelli, Francesco Tursi, Alessandro Zanforlin,
Gaetano Santulli, Bruno Trimarco
PII:
S1043-6618(22)00305-X
DOI:
https://doi.org/10.1016/j.phrs.2022.106360
Reference:
YPHRS106360
To appear in: Pharmacological Research
Received date: 10 June 2022
Revised date: 17 July 2022
Accepted date: 18 July 2022
Please cite this article as: Raffaele Izzo, Valentina Trimarco, Pasquale Mone,
Teresita Aloè, Massimo Capra Marzani, Antonio Diana, Giovanni Fazio, Mario
Mallardo, Mauro Maniscalco, Giuseppe Marazzi, Nunzia Messina, Simone
Mininni, Chiara Mussi, Girolamo Pelaia, Alfio Pennisi, Pierachille Santus,
Francesco Scarpelli, Francesco Tursi, Alessandro Zanforlin, Gaetano Santulli and
Bruno Trimarco, Combining L-Arginine with Vitamin C Improves Long-COVID
Symptoms: The Nationwide Multicenter LINCOLN Study,Pharmacological
Research, (2022) doi:https://doi.org/10.1016/j.phrs.2022.106360
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Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms:
The Nationwide Multicenter LINCOLN Study
Raffaele Izzoa1, Valentina Trimarcob,1, Pasquale Monec, Teresita Aloèd, Massimo Capra Marzanie,
Antonio Dianaf, Giovanni Faziog, Mario Mallardoh, Mauro Maniscalcoi, Giuseppe Marazzij,,
Nunzia Messinak, Simone Mininnil, Chiara Mussim, Girolamo Pelaian, Alfio Pennisio, Pierachille
Santusp, Francesco Scarpelliq, Francesco Tursir, Alessandro Zanforlins, Gaetano Santullit*, Bruno
of
Trimarcoa
ro
a: Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
-p
b: Department of Neuroscience, Reproductive Sciences and Dentistry, Federico II University,
Naples, Italy
lP
d: San Martino Hospital, Genoa, Italy
re
c: Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA
e: Alessandria Hospital, Alessandria, Italy
rn
a
f: Aversa Hospital, Aversa, Caserta, Italy
i: Palermo Hospital, Palermo, Italy
Jo
u
j: “San Gennaro” Hospital, Naples, Italy
k: Istituti Clinici Scientifici Maugeri IRCCS, Telese Terme, Italy
l: San Raffaele Hospital, Rome, Italy
m: ASL Napoli 1, Naples, Italy
12: Associazione Scientifica Interdisciplinare Aggiornamento Medico (ASIAM), Florence, Italy
n: Department of Biomedical and Metabolic Sciences and Neuroscience, University of Modena and
Reggio Emilia, Modena, Italy
o: Department of Health Science, Magna Graecia University, Catanzaro, Italy
1
Share first authorship
p: Catania Hospital, Catania, Italy
q: “Luigi Sacco” University Hospital, Milan, Italy
r: Trani Hospital, Trani (BT), Italy
s:..
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