The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study
Dengfeng Gao, Min Xu, Gang Wang, Jianrui Lv, Xiaorong Ma, Yonghong Guo, Dexin Zhang, Huiyun Yang, Wei Jiang, Fuxue Deng, Guozhi Xia, Ziwei Lu, Lv Lv, Shouping Gong
Background: The inflammatory reaction is the main cause of acute respiratory distress syndrome and multiple organ failure in patients with Coronavirus disease 2019, especially those with severe and critical illness. Several studies suggested that high-dose vitamin C reduced inflammatory reaction associated with sepsis and acute respiratory distress syndrome. This study aimed to determine the efficacy and safety of high-dose vitamin C in Coronavirus disease 2019. Methods: We included 76 patients with Coronavirus disease 2019, classified into the high-dose vitamin C group (loading dose of 6g intravenous infusion per 12 hr on the first day, and 6g once for the following 4 days, n=46) and the standard therapy group (standard therapy alone, n=30). Results: The risk of 28-day mortality was reduced for the high-dose vitamin C versus the standard therapy group (HR=0.14, 95% CI, 0.03-0.72). Oxygen support status was improved more with high-dose vitamin C than standard therapy (63.9% vs 36.1%). No safety events were associated with high-dose vitamin C therapy. Conclusion: High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.
Abbreviations COVID-19: Coronavirus disease 2019; WHO: World Health Organization; ARDS: acute respiratory distress syndrome; IQR: interquartile range; CIs: confidence intervals; hs-CRP: high-sensitivity C-reactive protein; PCT: procalcitonin; IL-1: interleukin-1; IL-2R: interleukin-2 receptor; IL-6: interleukin-6; IL-8: interleukin-8; IL-10: interleukin-10; TNF-α: tumor necrosis factor-α.
AUTHOR CONTRIBUTIONS
CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.
AGING SUPPLEMENTARY MATERIALS Supplementary Figures Supplementary Figure 1
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