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All Studies   Meta Analysis    Recent:   

High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 Pandemic

Guan et al., The American Journal of the Medical Sciences, doi:10.1016/j.amjms.2024.05.005
May 2024  
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0 0.5 1 1.5 2+ Symp. case, high dose 31% Improvement Relative Risk Symp. case, medium dose 18% Symp. case, low dose 7% Vitamin C for COVID-19  Guan et al.  Prophylaxis Is prophylaxis with vitamin C beneficial for COVID-19? Retrospective 2,621 patients in China (December 2022 - January 2023) Fewer symptomatic cases with vitamin C (p=0.0073) c19early.org Guan et al., The American J. the Medic.., May 2024 Favors vitamin C Favors control
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.000000038 from 71 studies, recognized in 12 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 2,746 individuals in China showing significantly lower incidence of COVID-19 symptoms and fever with higher vitamin C intake, with a dose response relationship.
This is the 71st COVID-19 controlled study for vitamin C, which collectively show efficacy with p=0.000000038 (1 in 26 million).
21 studies are RCTs, which show efficacy with p=0.0012.
risk of symptomatic case, 31.4% lower, RR 0.69, p = 0.007, treatment 28 of 46 (60.9%), control 2,017 of 2,454 (82.2%), NNT 4.7, adjusted per study, odds ratio converted to relative risk, high dose, multivariable.
risk of symptomatic case, 18.5% lower, RR 0.82, p = 0.02, treatment 55 of 79 (69.6%), control 2,017 of 2,454 (82.2%), NNT 8.0, adjusted per study, odds ratio converted to relative risk, medium dose, multivariable.
risk of symptomatic case, 6.8% lower, RR 0.93, p = 0.13, treatment 129 of 167 (77.2%), control 2,017 of 2,454 (82.2%), NNT 20, adjusted per study, odds ratio converted to relative risk, low dose, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Guan et al., 22 May 2024, retrospective, China, peer-reviewed, 5 authors, study period December 2022 - January 2023. Contact: huizheng@suda.edu.cn.
This PaperVitamin CAll
Abstract: Journal Pre-proof High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 Pandemic Mingcheng Guan MD , Yibo Zuo MD , Yukang Yuan MD , Hong Zhu PhD , Hui Zheng PhD PII: DOI: Reference: S0002-9629(24)01222-9 https://doi.org/10.1016/j.amjms.2024.05.005 AMJMS 2127 To appear in: The American Journal of the Medical Sciences Received date: Accepted date: 28 October 2023 14 May 2024 Please cite this article as: Mingcheng Guan MD , Yibo Zuo MD , Yukang Yuan MD , Hong Zhu PhD , Hui Zheng PhD , High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 Pandemic, The American Journal of the Medical Sciences (2024), doi: https://doi.org/10.1016/j.amjms.2024.05.005 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2024 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation. High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 Pandemic Mingcheng Guan MD1, Yibo Zuo MD3,4, Yukang Yuan MD3,4, Hong Zhu PhD1, Hui Zheng PhD2,3 1 Department of Medical Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China 2 Department / Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China 3 International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China 4 Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou, China Corresponding author: Prof. Hui Zheng, Department / Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, 611731 Chengdu, Sichuan, China; International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, 215123 Suzhou, Jiangsu, China.; E-mail: huizheng@suda.edu.cn; 1 Short title: Association of Vitamin C with COVID-19 Acknowledgements: We thank all members of Hui Zheng’s lab for the collection of the questionnaire. We also thank Prof. Guideng Li for the advice of the questionnaire. Financial Support: This research was funded by the National Natural Science Foundation of China (32100568, 31970846, 82171834), Jiangsu Provincial Distinguished Young Scholars (BK20130004), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Suzhou Science and Technology Development Plan Project (No. SKY2023049). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Conflict of Interest Statement: None of the authors have any conflicts of interest to declare. Authorship: HZheng and MG principally conceived and designed the study in consultation with YZ, YY and HZhu...
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