Abstract: Journal Pre-proof
High-dose Vitamin C Intake and COVID-19 Related Symptoms
During the SARS-CoV-2 Pandemic
Mingcheng Guan MD , Yibo Zuo MD , Yukang Yuan MD ,
Hong Zhu PhD , Hui Zheng PhD
PII:
DOI:
Reference:
S0002-9629(24)01222-9
https://doi.org/10.1016/j.amjms.2024.05.005
AMJMS 2127
To appear in:
The American Journal of the Medical Sciences
Received date:
Accepted date:
28 October 2023
14 May 2024
Please cite this article as: Mingcheng Guan MD , Yibo Zuo MD , Yukang Yuan MD , Hong Zhu PhD ,
Hui Zheng PhD , High-dose Vitamin C Intake and COVID-19 Related Symptoms During
the SARS-CoV-2 Pandemic, The American Journal of the Medical Sciences (2024), doi:
https://doi.org/10.1016/j.amjms.2024.05.005
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition
of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of
record. This version will undergo additional copyediting, typesetting and review before it is published
in its final form, but we are providing this version to give early visibility of the article. Please note that,
during the production process, errors may be discovered which could affect the content, and all legal
disclaimers that apply to the journal pertain.
© 2024 Published by Elsevier Inc. on behalf of Southern Society for Clinical Investigation.
High-dose Vitamin C Intake and COVID-19 Related Symptoms During the
SARS-CoV-2 Pandemic
Mingcheng Guan MD1, Yibo Zuo MD3,4, Yukang Yuan MD3,4, Hong Zhu PhD1, Hui
Zheng PhD2,3
1
Department of Medical Oncology, The First Affiliated Hospital of Soochow
University, Suzhou, China
2
Department / Institute of Laboratory Medicine, Sichuan Provincial People's
Hospital, School of Medicine, University of Electronic Science and Technology of
China, Chengdu, China
3
International Institute of Infection and Immunity, Institutes of Biology and
Medical Sciences, Soochow University, Suzhou, China
4
Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou,
China
Corresponding author: Prof. Hui Zheng, Department / Institute of Laboratory
Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of
Electronic Science and Technology of China, 611731 Chengdu, Sichuan, China;
International Institute of Infection and Immunity, Institutes of Biology and Medical
Sciences, Soochow University, 215123 Suzhou, Jiangsu, China.; E-mail:
huizheng@suda.edu.cn;
1
Short title: Association of Vitamin C with COVID-19
Acknowledgements: We thank all members of Hui Zheng’s lab for the collection of
the questionnaire. We also thank Prof. Guideng Li for the advice of the
questionnaire.
Financial Support: This research was funded by the National Natural Science
Foundation of China (32100568, 31970846, 82171834), Jiangsu Provincial
Distinguished Young Scholars (BK20130004), and the Priority Academic Program
Development of Jiangsu Higher Education Institutions (PAPD), the Suzhou Science
and Technology Development Plan Project (No. SKY2023049). The funders had no
role in the design and conduct of the study; collection, management, analysis, and
interpretation of the data; preparation, review, or approval of the manuscript; and
decision to submit the manuscript for publication.
Conflict of Interest Statement: None of the authors have any conflicts of interest to
declare.
Authorship: HZheng and MG principally conceived and designed the study in
consultation with YZ, YY and HZhu...
{ 'indexed': {'date-parts': [[2024, 5, 24]], 'date-time': '2024-05-24T00:19:55Z', 'timestamp': 1716509995051},
'reference-count': 13,
'publisher': 'Elsevier BV',
'license': [ { 'start': { 'date-parts': [[2024, 5, 1]],
'date-time': '2024-05-01T00:00:00Z',
'timestamp': 1714521600000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'},
{ 'start': { 'date-parts': [[2024, 5, 1]],
'date-time': '2024-05-01T00:00:00Z',
'timestamp': 1714521600000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/legal/tdmrep-license'}],
'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.com.au', 'clinicalkey.es',
'amjmedsci.org', 'clinicalkey.com', 'elsevier.com', 'sciencedirect.com'],
'crossmark-restriction': True},
'published-print': {'date-parts': [[2024, 5]]},
'DOI': '10.1016/j.amjms.2024.05.005',
'type': 'journal-article',
'created': {'date-parts': [[2024, 5, 22]], 'date-time': '2024-05-22T16:08:10Z', 'timestamp': 1716394090000},
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 Pandemic',
'prefix': '10.1016',
'author': [ {'given': 'Mingcheng', 'family': 'Guan', 'sequence': 'first', 'affiliation': []},
{'given': 'Yibo', 'family': 'Zuo', 'sequence': 'additional', 'affiliation': []},
{'given': 'Yukang', 'family': 'Yuan', 'sequence': 'additional', 'affiliation': []},
{'given': 'Hong', 'family': 'Zhu', 'sequence': 'additional', 'affiliation': []},
{'given': 'Hui', 'family': 'Zheng', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'reference': [ { 'issue': '5',
'key': '10.1016/j.amjms.2024.05.005_bib0001',
'doi-asserted-by': 'crossref',
'DOI': '10.1093/jtm/taad049',
'article-title': 'Reproduction number of SARS-CoV-2 omicron variants, China, December '
'2022-January 2023',
'volume': '30',
'author': 'Bai',
'year': '2023',
'journal-title': 'J Travel Med'},
{ 'issue': '5',
'key': '10.1016/j.amjms.2024.05.005_bib0002',
'doi-asserted-by': 'crossref',
'first-page': '906',
'DOI': '10.1016/j.cell.2023.01.039',
'article-title': 'Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic',
'volume': '186',
'author': 'Oudit',
'year': '2023',
'journal-title': 'Cell'},
{ 'issue': '1',
'key': '10.1016/j.amjms.2024.05.005_bib0003',
'doi-asserted-by': 'crossref',
'first-page': '216',
'DOI': '10.1186/s12916-020-01673-z',
'article-title': 'New insights into genetic susceptibility of COVID-19: an ACE2 and '
'TMPRSS2 polymorphism analysis',
'volume': '18',
'author': 'Hou',
'year': '2020',
'journal-title': 'BMC Med'},
{ 'issue': '4',
'key': '10.1016/j.amjms.2024.05.005_bib0004',
'doi-asserted-by': 'crossref',
'first-page': 'e56374',
'DOI': '10.15252/embr.202256374',
'article-title': 'Vitamin C promotes ACE2 degradation and protects against SARS-CoV-2 '
'infection',
'volume': '24',
'author': 'Zuo',
'year': '2023',
'journal-title': 'EMBO Rep'},
{ 'issue': '1',
'key': '10.1016/j.amjms.2024.05.005_bib0005',
'doi-asserted-by': 'crossref',
'first-page': '290',
'DOI': '10.1186/s12916-021-02168-1',
'article-title': 'Nutritional risk factors for SARS-CoV-2 infection: a prospective study '
'within the NutriNet-Sante cohort',
'volume': '19',
'author': 'Deschasaux-Tanguy',
'year': '2021',
'journal-title': 'BMC Med'},
{ 'issue': '6',
'key': '10.1016/j.amjms.2024.05.005_bib0006',
'doi-asserted-by': 'crossref',
'first-page': '821',
'DOI': '10.1016/S1473-3099(22)00069-X',
'article-title': 'SARS-CoV-2 incidence, transmission, and reinfection in a rural and an '
'urban setting: results of the PHIRST-C cohort study, South Africa, '
'2020-21',
'volume': '22',
'author': 'Cohen',
'year': '2022',
'journal-title': 'Lancet Infect Dis'},
{ 'issue': '10',
'key': '10.1016/j.amjms.2024.05.005_bib0007',
'doi-asserted-by': 'crossref',
'first-page': '1444',
'DOI': '10.1016/S1473-3099(22)00416-9',
'article-title': 'Efficacy and safety of a single dose of casirivimab and imdevimab for '
'the prevention of COVID-19 over an 8-month period: a randomised, '
'double-blind, placebo-controlled trial',
'volume': '22',
'author': 'Herman',
'year': '2022',
'journal-title': 'Lancet Infect Dis'},
{ 'issue': '23',
'key': '10.1016/j.amjms.2024.05.005_bib0008',
'doi-asserted-by': 'crossref',
'first-page': '2188',
'DOI': '10.1056/NEJMoa2116620',
'article-title': 'Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of '
'Covid-19',
'volume': '386',
'author': 'Levin',
'year': '2022',
'journal-title': 'N Engl J Med'},
{ 'issue': '7',
'key': '10.1016/j.amjms.2024.05.005_bib0009',
'doi-asserted-by': 'crossref',
'first-page': '2008',
'DOI': '10.3390/nu12072008',
'article-title': 'Global Vitamin C Status and Prevalence of Deficiency: A Cause for '
'Concern?',
'volume': '12',
'author': 'Rowe',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.amjms.2024.05.005_bib0010',
'series-title': 'Institute of Medicine: Dietary Reference Intakes for Vitamin C, Vitamin '
'E, Selenium and Carotenoids',
'first-page': '95',
'year': '2000'},
{ 'issue': '8',
'key': '10.1016/j.amjms.2024.05.005_bib0011',
'doi-asserted-by': 'crossref',
'first-page': '3704',
'DOI': '10.1073/pnas.93.8.3704',
'article-title': 'Vitamin C pharmacokinetics in healthy volunteers: evidence for a '
'recommended dietary allowance',
'volume': '93',
'author': 'Levine',
'year': '1996',
'journal-title': 'Proc Natl Acad Sci U S A'},
{ 'issue': '2',
'key': '10.1016/j.amjms.2024.05.005_bib0012',
'doi-asserted-by': 'crossref',
'first-page': '653',
'DOI': '10.1007/s10787-023-01169-1',
'article-title': 'The effects of vitamin C on respiratory, allergic and immunological '
'diseases: an experimental and clinical-based review',
'volume': '31',
'author': 'Ghalibaf',
'year': '2023',
'journal-title': 'Inflammopharmacology'},
{ 'issue': '8',
'key': '10.1016/j.amjms.2024.05.005_bib0013',
'doi-asserted-by': 'crossref',
'first-page': '1580',
'DOI': '10.3390/antiox11081580',
'article-title': 'Vitamin C Deficiency in Blood Samples of COVID-19 Patients',
'volume': '11',
'author': 'Sinnberg',
'year': '2022',
'journal-title': 'Antioxidants (Basel)'}],
'container-title': 'The American Journal of the Medical Sciences',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0002962924012229?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S0002962924012229?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2024, 5, 23]],
'date-time': '2024-05-23T08:11:35Z',
'timestamp': 1716451895000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0002962924012229'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2024, 5]]},
'references-count': 13,
'alternative-id': ['S0002962924012229'],
'URL': 'http://dx.doi.org/10.1016/j.amjms.2024.05.005',
'relation': {},
'ISSN': ['0002-9629'],
'subject': [],
'container-title-short': 'The American Journal of the Medical Sciences',
'published': {'date-parts': [[2024, 5]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'High-dose Vitamin C Intake and COVID-19 Related Symptoms During the SARS-CoV-2 '
'Pandemic',
'name': 'articletitle',
'label': 'Article Title'},
{ 'value': 'The American Journal of the Medical Sciences',
'name': 'journaltitle',
'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.amjms.2024.05.005',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'simple-article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2024 Published by Elsevier Inc. on behalf of Southern Society for Clinical '
'Investigation.',
'name': 'copyright',
'label': 'Copyright'}]}
