The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial
Majidi et al.,
The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease..,
Frontiers in Immunology, doi:10.3389/fimmu.2021.717816
RCT 100 ICU patients in Iran, 31 treated with vitamin C, showing lower mortality with treatment. IRCT20151226025699N5.
risk of death, 13.6% lower, RR 0.86, p = 0.03, treatment 26 of 31 (83.9%), control 67 of 69 (97.1%), NNT 7.6, day 28.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Majidi et al., 15 Dec 2021, Double Blind Randomized Controlled Trial, Iran, peer-reviewed, 16 authors, study period May 2020 - July 2020.
Abstract: ORIGINAL RESEARCH
published: 15 December 2021
doi: 10.3389/fimmu.2021.717816
The Effect of Vitamin C on
Pathological Parameters and
Survival Duration of Critically Ill
Coronavirus Disease 2019 Patients:
A Randomized Clinical Trial
Nazanin Majidi 1, Faezeh Rabbani 2, Somayeh Gholami 3, Maryam Gholamalizadeh 4,
Fatemeh BourBour 5, Samira Rastgoo 5, Azadeh Hajipour 6, Mahdi Shadnoosh 7,
Mohammad Esmail Akbari 4, Bojlul Bahar 8, Narjes Ashoori 5, Atiyeh Alizadeh 9,
Forough Samipoor 3, Alireza Moslem 10, Saeid Doaei 11* and Katsuhiko Suzuki 12*
Edited by:
Alberto Finamore,
Council for Agricultural and Economics
Research (CREA), Italy
Reviewed by:
Paul Ellis Marik,
Eastern Virginia Medical School,
United States
Raffaella Comitato,
Council for Agricultural and Economics
Research (CREA), Italy
*Correspondence:
Saeid Doaei
Sdoaee@yahoo.com
Katsuhiko Suzuki
katsu.suzu@waseda.jp
Specialty section:
This article was submitted to
Nutritional Immunology,
a section of the journal
Frontiers in Immunology
Received: 31 May 2021
Accepted: 24 November 2021
Published: 15 December 2021
Citation:
Majidi N, Rabbani F, Gholami S,
Gholamalizadeh M, BourBour F,
Rastgoo S, Hajipour A, Shadnoosh M,
Akbari ME, Bahar B, Ashoori N,
Alizadeh A, Samipoor F, Moslem A,
Doaei S and Suzuki K (2021) The Effect
of Vitamin C on Pathological
Parameters and Survival Duration of
Critically Ill Coronavirus Disease 2019
Patients: A Randomized Clinical Trial.
Front. Immunol. 12:717816.
doi: 10.3389/fimmu.2021.717816
1 Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran, 2 Department of Medicinal
Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical
Sciences, Yazd, Iran, 3 Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran, 4 Cancer Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran, 5 Department of Clinical Nutrition and Dietetics, Research Institute
Shahid Beheshti University of Medical Science, Tehran, Iran, 6 School of Health, Qazvin University of Medical Sciences,
Qazvin, Iran, 7 Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and
Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 8 Nutrition Sciences and
Applied Food Safety Studies, Research Centre for Global Development, School of Sport & Health Sciences, University of
Central Lancashire, Preston, United Kingdom, 9 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of
Medical Science, Tehran, Iran, 10 Department of Anesthesiology, Sabzevar University of Medical Sciences, Sabzevar, Iran,
11 Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital,
Guilan University of Medical Sciences, Rasht, Iran, 12 Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan
Introduction: Vitamin C has been reported to have beneficial effects on patients with
coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin
C supplementation on pathological parameters and survival duration of critically ill patients
with COVID-19.
Methods: This clinical trial was conducted on 120 hospitalized critically ill patients infected
with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin
C daily for 14 days. The control group (n = 69) received the same nutrition except..
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