The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial
Nazanin Majidi, Faezeh Rabbani, Somayeh Gholami, Maryam Gholamalizadeh, Fatemeh Bourbour, Samira Rastgoo, Azadeh Hajipour, Mahdi Shadnoosh, Mohammad Esmail Akbari, Bojlul Bahar, Narjes Ashoori, Atiyeh Alizadeh, Forough Samipoor, Alireza Moslem, Saeid Doaei, Katsuhiko Suzuki
Frontiers in Immunology, doi:10.3389/fimmu.2021.717816
Conclusion: The present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19.
ETHICS STATEMENT The studies involving human participants were reviewed and approved by Ethical code: IR.MEDSAB.REC.1399.195. The patients/participants provided their written informed consent to participate in this study.
AUTHOR CONTRIBUTIONS NM, AH, SD, SG, SR, MG, FB, and NA designed the study and were involved in the data collection, analysis, and drafting of the manuscript. MA, BB, NA, AA, MSh, FS, AM, and KS were involved in the design of the study and analysis of the data and critically reviewed the manuscript. BB contributed to the data analysis and review of the manuscript. All authors contributed to the article and approved the submitted version.
FUNDING The funding for this study was provided by Sabzevar University of Medical Sciences, Sabzevar, Iran (code 99213).
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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doi:10.1007/s12272-020-01258-7{ 'indexed': { 'date-parts': [[2021, 12, 16]],
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'abstract': '<jats:sec><jats:title>Introduction</jats:title><jats:p>Vitamin C has been reported to have '
'beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to '
'investigate the effect of vitamin C supplementation on pathological parameters and survival '
'duration of critically ill patients with '
'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This clinical '
'trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The '
'intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. '
'The control group (n = 69) received the same nutrition except for vitamin C supplements. '
'Measurement of pathological and biochemical parameters was performed at baseline and after 2 '
'weeks of the '
'intervention.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Following '
'2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the '
'patients compared with the control group (3.93 vs. 4.21 mEq/L, <jats:italic>p</jats:italic> '
'&lt; 0.01). Vitamin C supplementation resulted in a higher mean survival duration '
'compared with that of the control group (8 vs. 4 days, <jats:italic>p</jats:italic> &lt; '
'0.01). There was a linear association between the number of days of vitamin C intake and '
'survival duration (B = 1.66, <jats:italic>p</jats:italic> &lt; 0.001). The vitamin C '
'supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas '
'(ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), '
'hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit '
'(Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus '
'(P).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The present '
'study demonstrated the potential of vitamin C supplementation in enhancing the survival '
'duration of critically ill patients with '
'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Clinical Trial '
'Registration</jats:title><jats:p><jats:uri>https://www.irct.ir/trial/55074</jats:uri>, '
'identifier IRCT20151226025699N5</jats:p></jats:sec>',
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