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SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)

Fowler et al., NCT04344184, SAFE EVICT CORONA-ALI, NCT04344184

Apr 2024

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Vitamin C for COVID-19

6th treatment shown to reduce risk in September 2020, now with p = 0.00000002 from 73 studies, recognized in 12 countries.

Lower risk for mortality, ICU admission, hospitalization, and recovery.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

RCT 47 ICU patients showing no significant differences with vitamin C treatment.

Although the 19% lower mortality is not statistically significant, it is consistent with the significant 20% lower mortality [10‑28%] from meta analysis of the 44 mortality results to date.

This is the 21st COVID-19 RCT for vitamin C, which collectively show efficacy with p=0.0012.

This is the 70th of 73 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000002 (1 in 50 million).

This study is excluded in the after exclusion results of meta analysis: very late stage, ICU patients.

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risk of death, 18.8% lower, RR 0.81, p = 0.75, treatment 5 of 22 (22.7%), control 7 of 25 (28.0%), NNT 19.

relative WHO status, 1.7% worse, RR 1.02, p = 0.28, treatment mean 3.05 (±0.22) n=21, control mean 3.0 (±0.0) n=23, day 27.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Fowler et al., 4 Apr 2024, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04344184 (history) (SAFE EVICT CORONA-ALI).

This Paper Vitamin C All

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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