The Effect of a Low Dose of Vitamin C in Patients With COVID-19: A Double-Blind Randomized Controlled Trial
Sajedeh Mousaviasl, Sara Sayar, Esmat Radmanesh, Bagher Pahlavanzade, Hani Esmaeilian, Mona Ebrahimzadeh, Raha Tabahfar, Maryam Khalili, Tara Borzoo, Saeed Jelvay, Saeid Bitaraf, Mahshid Naghashpour, Sara Mobarak
Disease and Diagnosis, doi:10.34172/ddj.500
Background: Vitamin C is a micronutrient with anti-inflammatory and free radical scavenging properties that can strengthen the body's immune system. In this study, it was attempted to assess the clinical efficiency of oral vitamin C in treating COVID-19. Materials and Methods: This double-blind randomized clinical trial was conducted on 401 patients hospitalized in Taleghani hospital, Abadan, over 18 years of age and with confirmed COVID-19 infection, from November 2020 to May 2021. The patients were randomly assigned to intervention groups (201 people, two tablets per day, each containing 500 mg of vitamin C) and the control group (200 people, placebo, containing starch received for five days). Improvements in clinical symptoms, death from baseline to the 28-day follow-up after the intervention, hospital length of stay, and laboratory values of C-reactive protein (CRP) were some of the considered outcome variables. Results: No significant difference was observed between the two groups in terms of the daily improvement of clinical symptoms and the odds of healing from each symptom increased by about 48-50%. The difference in the length of hospital stay between the two groups was close to significant (P = 0.051). There was no significant difference in mortality between the two groups (P = 0.8). There was no difference between the two groups in the laboratory parameters, except for alkaline phosphatase (P = 0.03). Conclusion: Vitamin C had no significant effect on improving patients' clinical symptoms such as fatigue, fever, cough, and shortness of breath.
Authors' Contribution
Competing Interests The authors declare that they have no conflict of interests regarding the publication of this study.
Disclaimer This article doesn't have prior publication or presentation in a conference/seminar.
Ethical Approval The protocol of this study was approved by Abadan Medical Sciences Ethics Committee with the ethics code IR.ABADANUMS. REC.1398.119. The trial was conducted in accordance with the principles of the Declaration of Helsinki and registered in the Iranian Registry of Clinical Trials (www.irct.ir) on April 4, 2020 (identifier: IRCT20200324046850N5; https://www.irct.ir/).
Informed Consent All participants gave their written informed consent after receiving explanations regarding the study objective and methodology.
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'abstract': '<jats:p>Background: Vitamin C is a micronutrient with anti-inflammatory and free radical '
'scavenging properties that can strengthen the body’s immune system. In this study, it was '
'attempted to assess the clinical efficiency of oral vitamin C in treating COVID-19. Materials '
'and Methods: This double-blind randomized clinical trial was conducted on 401 patients '
'hospitalized in Taleghani hospital, Abadan, over 18 years of age and with confirmed COVID-19 '
'infection, from November 2020 to May 2021. The patients were randomly assigned to '
'intervention groups (201 people, two tablets per day, each containing 500 mg of vitamin C) '
'and the control group (200 people, placebo, containing starch received for five days). '
'Improvements in clinical symptoms, death from baseline to the 28-day follow-up after the '
'intervention, hospital length of stay, and laboratory values of C-reactive protein (CRP) were '
'some of the considered outcome variables. Results: No significant difference was observed '
'between the two groups in terms of the daily improvement of clinical symptoms and the odds of '
'healing from each symptom increased by about 48-50%. The difference in the length of hospital '
'stay between the two groups was close to significant (P=0.051). There was no significant '
'difference in mortality between the two groups (P=0.8). There was no difference between the '
'two groups in the laboratory parameters, except for alkaline phosphatase (P=0.03). '
'Conclusion: Vitamin C had no significant effect on improving patients’ clinical symptoms such '
'as fatigue, fever, cough, and shortness of breath.</jats:p>',
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