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All Studies   Meta Analysis    Recent:   

High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019

Xia et al., Nutrition, doi:10.1016/j.nut.2021.111405
Nov 2021  
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Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
 
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Retrospective study of 236 hospitalized patients with severe COVID-19 in China. 85 patients received high-dose intravenous vitamin C (HIVC) along with standard care, 151 received standard care alone. Most patients showed signs of hyperinflammation based on elevated inflammatory marker levels. After treatment, inflammatory marker levels decreased more in the HIVC group compared to standard care alone. Multiple regression analysis showed HIVC treatment was independently associated with greater reductions in hs-CRP, IL-6, and TNF-⍺. See also Xia.
Xia et al., 30 Nov 2021, retrospective, China, peer-reviewed, 5 authors, study period 1 February, 2020 - 10 March, 2020. Contact: hatozy@126.com.
This PaperVitamin CAll
High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019
Guozhi Xia, Di Fan, Yanru He, Yaohu Zhu, Ph.D Qiangsun Zheng
Nutrition, doi:10.1016/j.nut.2021.111405
High-dose intravenous vitamin C (HIVC) is a major concern when treating patients with coronavirus disease 2019 . The aim of this study was to assess the clinical efficacy of HIVC on hyperinflammation in patients with severe COVID-19. Methods: This retrospective cohort study included hospitalized patients with severe COVID-19, a subset of whom was treated with HIVC. The medical records were screened for demographic data, laboratory findings, and medications, as well as initial and repeated values of multiple inflammatory markers for analysis. Results: A high percentage of patients presented with hyperinflammation based on inflammatory marker levels above the upper limit of normal (high-sensitivity C-reactive protein, 80.1%; interleukin-6, 91.5%; and tumor necrosis factor-a, 67.4%). Eighty-five (36%) patients received HIVC therapy. After treatment with HIVC, the levels of inflammatory markers displayed a significant decrease compared with those of patients without HIVC. Furthermore, the percentages of reduction in inflammatory marker levels were higher in patients receiving HIVC compared with those in patients treated without HIVC. Stepwise multiple linear regression analysis revealed that HIVC was independently associated with percentages of reduction in levels of inflammatory markers. Conclusions: HIVC has the potential benefit of attenuating hyperinflammation by reducing inflammatory marker levels in patients with severe COVID-19.
References
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