ESICM LIVES 2021: Part 1
J Azevedo, ; H Lima, ; P Frota, ; I Nogueira, ; S Souza, ; E Fernandes, H Effat, MD Rania Alhusseiny, MD. Waleed Farouk, R Mackey, ; J Textoris, ; N Rosenthal, ; La Carabuena, ; J Kampf, ; A Sanghani, ; T Rodriguez, ; P Mcpherson, ; J Koyner, L Chan, Timsina P Li, S Eggmann, ; I Irincheeva, ; G Luder, ; Ml Verra, ; A Moser, Bastiaenen, S M Jakob, J Tirkkonen, ; E Loisa, ; S Hoppu, ; A Kallonen, E Kooistra, ; S Brinkman, ; Dvp Van, ; N De Keizer, ; D Dongelmans, ; M Kox, ; P Pickkers, S Uhrenholt, ; S Linér, ; J Stokholm, ; T Christiensen, ; Mh Bestle, H Kobayashi, ; K Amrein, ; J Lanky-Su, ; K Christopher, H K Johal, ; G Birchley, ; W Orchard, ; R Huxtable, A Tabah, ; N Buetti, ; F Barbier, A T Aslan, ; S Ruckly, ; Q Staiquly, ; C Dallongeville, ; N Eurobact, Ii National, Ii Contributors, J F Timsit, P Damas, ; B Lambermont, ; C Legrain, A F Rousseau, ; P Demaret, ; B Misset, Scaravilli V, Mangioni D, Scudeller L, Alagna L, Bartoletti M, Bellani G, Biagioni E, Bonfanti P, Bottino N, Coloretti I G Grasselli, Cutuli Sl, Pascale G De, J Weblin, ; A Harriman, ; D Mcwilliams, C Sánchez Ramírez, ; S Hípola Escalada, ; Re Morales Sirgado, ; Ma Hernández Viera, ; M Cabrera, ; C Rodriguez Mata, Gallardo Santos, C F Lübbe Vázquez, S M Marrero Penichet, ; A Padrón Mujica, ; P Saavedra-Santana, ; S Ruiz-Santana, K Lelu-Santolaria, ; C Dubois, ; M Baldazza, ; A Evlachev, ; N Kehrer, ; R Brandely, ; Y Schlesinger, ; N Silvestre, ; J Unsinger, ; R Hotchkiss, ; P Martin, ; G Inchauspe, G Inchauspe, M Van Mol, ; S Wagener, ; J Rietjens, ; C Den Uil, A Jansen, ; N Bruse, ; N Waalders, L F Reyes, J A Sanchez Giralt, ; M Wallin, ; M Hallbäck, ; T Gerardo, ; M Sánchez Galindo, ; B Abad Santamaría, ; Ma Pérez Lucendo, ; A Canabal Berlanga, ; F Suarez-Sipmann, B Abad Santamaría, M Wallin, M Hallbäck, M Trigueros Genao, J Lázaro Gonzalez, B Muñoz Molina, G Tusman, F Suarez, M Crinage, ; C Woods, ; L Cawtheray, D Mcwilliams, J Dianti, ; S Fard, ; J Wong, ; Cc Timothy, S L Del, ; E Fan, ; M Amato, ; J Granton, ; L Burry, ; D Reid, ; S Keshavjee, ; A Slutsky, ; L Brochard, Ferguson, ; Ec Goligher, J Diant, L Wihersaari, J Laurikkala, ; A Aneman, ; A Peng, ; M Reinikainen, ; P Pham, ; P Jakkula, ; J Hastbacka, ; E Wilkman, ; P Loisa, ; J Toppila, ; T Birkelund, ; K Blennow, ; H Zetterberg, ; M Skrifvars, R Beunders, ; L Donato, ; R Van Groenendael, ; B Arlt, ; C Carvalho, ; J Schulte, ; A Coolen, ; J Lieske, ; J Meeusen, ; A Jaffe, L Premraj, ; A Zaaqoq, ; Ag Barnett, ; J Fanning, ; G Peek, ; S Huth, ; R Arora, ; J Bellapart-Rubio, ; D Battaglini, ; G Li, ; J Fraser, ; C Robba, ; M Griffee, S M Cho, J Y Suen, ; J Weblin, ; M Crinage, N Kok, ; J Van Gurp, ; M Fuchs, ; H Van Der Hoeven, ; Cwe, Hoedemaekers, ; M Zegers, S Siddiqui, F Iannuzzi, ; L Ball, ; I Brunetti, ; M Bassetti, ; Dr, Giacobbe, ; A Vena, ; N Patroniti, ; P Rocco, ; Bf Matta, ; P Pelosi, L Ball, Serpa Neto, Gama De Abreu, Schultz Mj, Rocco Prm, P Pelosi, T Bassi, ; R Elizabeth, ; F Karl, ; N Michelle, ; M Ornowska, ; G Matt, Doug, ; S Reynolds, A Ughetto, ; J Eliet, ; H David, ; N Nagot, ; F Bazalgette, ; G Marin, ; M Mourad, ; S Kollen, ; P Gaudard, ; P Colson, A Del Pozo, ; E Giustiniano, ; N Fusilli, ; V Simili, ; L Calabro', ; L Pugliese, ; N Stomeo, ; C Ebm, ; S Brusa, ; J Echeverri, ; Mj Blackowicz, ; T Rodriguez, Amham M H A M Mostafa, C J Tuttle, M A Mckie, J A Fowles, ; A Vuylsteke, M Kopczynska, ; H Unwin, ; R Pugh, ; B Sharif
Intensive Care Medicine Experimental, doi:10.1186/s40635-021-00413-8
Introduction. The optimal integration between adequate protein intake and exercise in critically ill patients may have an impact on short and long-term outcomes, but this hypothesis has not been tested in studies with good methodology. In the given context, we conducted a prospective randomized controlled trial to evaluate the efficacy of high protein intake and early exercise versus guidelines recommended protein intake and routine physiotherapy on outcome of critically ill patients. Methods. We randomized mechanically ventilated patients expected to stay in the intensive care unit (ICU) for at least 4 days. We used indirect calorimetry to determine energy expenditure and guide caloric provision to the patients randomized to the high protein and early exercise (HPE) group and the control group. Protein intakes were 2.0 g/ kg/day and 1.4 g/kg/day respectively; while the former was submitted to two daily sessions of cycle ergometry exercise, the latter received routine physiotherapy. We evaluated the primary outcome physical component summary (PCS) score at 3 and 6 months) and the secondary outcomes (handgrip strength at ICU discharge and ICU and hospital mortality). Results. We analyzed 181 patients in the HPE (87) and control (94) group. There was no significant difference between groups in relation to the calories received. However, the amount of protein received by the HPE group was significantly higher than that received by the control group (p < 0.0001). The PCS score was significantly higher in the HPE group at 3 months (p = 0.01) and 6 months (p = 0.01). The hospital mortality was expressively higher in the control group (p = 0.006). We found an independent association between age and 3-month PCS and that between age and group and 6-month PCS.
Conclusion. This study showed that a high-protein intake and resistive exercise increase the survival rate and the physical quality of life of critically ill patients.
Conflict of interest: FILMARRAY ® Pneumonia Plus Panels and QC-material was sponsored by BioMérieux SA along with cost of shipment. All agreements have been revised and approved by the Unit for Research an Innovation, The Capital Region of Denmark.
Determination of Serum Zinc and Copper Levels and Their Relation with Mortality in Critically Ill Patients M. Yildirim, 1 ; B. Kesikli, 2 ; L. Talan, 3 ; MA. Tekes, 4 ; N. Yazıhan, 2 ; ND. Altintas 3 000320 The effect of high flow oxygen via tracheostomy on diaphragm function in patients with prolonged weaning from mechanical ventilation: a randomized crossover study E. Lytra 1 ; I. Poularas 2 ; D. Cokkinos 1 ; Y. Papachatzakis 2 ; V. Vlachakos 2 ; P. Ampatzis 1 ; D. Exarchos 1 ; D. Filippiadis 3 ; S. Zakynthinos 2 ; C. Routsi 2 1 Department of radiology, Evangelismos Hospital, Athens, Greece; ICMx 2021, 9(Suppl 1):51 Results. 65 patients were included. 90-day mortality in this series was 30.8% (n = 20). Table 1 shows the variables that proved statistically significant impact on 90-day mortality in this subset of patients.
Variables
Conclusion. This study brings perspective on how clinical evolution during ICU stay of the patients who underwent mechanical ventilation due to severe COVID-19 predicts 90-day mortality. In fact, a higher SAPS II score and aaCCI significantly decrease the odds of being alive 90 days after ICU admission. Higher PaO2/FiO2 ratios thoughout days 2 to 5 of IMV significantly increase the odds of a..
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