Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19; multi-center retrospective study
Yüksel et al.
, Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19;..
, Intensive Care Medicine Experimental, 9:S1, 001458, doi:10.1186/s40635-021-00413-8 (Preprint)
risk of death, 18.8% lower, RR 0.81, p = 0.04, treatment 31 of 42 (73.8%), control 40 of 44 (90.9%), NNT 5.8, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yüksel et al., 20 Sep 2020, retrospective, Turkey, preprint, 13 authors.
Abstract: ICMx 2021, 9(Suppl 1):51
Intensive Care Medicine
ESICM LIVES 2021: Part 1
Virtual 03-06 October 2021
Published: 11 October 2021
Best Oral Presentations 1
High‑Protein Intake and Early Exercise in Adult Intensive Care
Patients: A Randomized Controlled Phase III Study to Evaluate
the Impact on Functional Outcomes
J. Azevedo1; H. Lima2; P. Frota1; I. Nogueira1; S. Souza3; E. Fernandes1
Intensive care unit, Hospital São Domingos, São Luís, Brazil; 2Icu, Hospital
São Domingos, São Luís, Brazil; 3Intensive care unit, Hospital São Domingos, Sao Luis, Brazil
Correspondence: J. Azevedo
Intensive Care Medicine Experimental 2020, 9(1): 000100
Introduction. The optimal integration between adequate protein
intake and exercise in critically ill patients may have an impact on
short and long-term outcomes, but this hypothesis has not been
tested in studies with good methodology. In the given context, we
conducted a prospective randomized controlled trial to evaluate the
efficacy of high protein intake and early exercise versus guidelines recommended protein intake and routine physiotherapy on outcome of
critically ill patients.
Methods. We randomized mechanically ventilated patients expected
to stay in the intensive care unit (ICU) for at least 4 days. We used indirect calorimetry to determine energy expenditure and guide caloric
provision to the patients randomized to the high protein and early
exercise (HPE) group and the control group. Protein intakes were 2.0 g/
kg/day and 1.4 g/kg/day respectively; while the former was submitted
to two daily sessions of cycle ergometry exercise, the latter received
routine physiotherapy. We evaluated the primary outcome physical
component summary (PCS) score at 3 and 6 months) and the secondary outcomes (handgrip strength at ICU discharge and ICU and hospital mortality).
Results. We analyzed 181 patients in the HPE (87) and control (94)
group. There was no significant difference between groups in relation
to the calories received. However, the amount of protein received by
the HPE group was significantly higher than that received by the control group (p < 0.0001). The PCS score was significantly higher in the
HPE group at 3 months (p = 0.01) and 6 months (p = 0.01). The hospital mortality was expressively higher in the control group (p = 0.006).
We found an independent association between age and 3-month PCS
and that between age and group and 6-month PCS.
Conclusion. This study showed that a high-protein intake and resistive exercise increase the survival rate and the physical quality of life of
critically ill patients.
Fluid Management In Critically Ill Patients With Acute Kidney
Injury: Role Of Noninvasive Assessment of Stroke Volume
Critical Care Medicine, Cairo University, Cairo, Egypt
Correspondence: H. Effat
Intensive Care Medicine Experimental 2020, 9(1): 000160
Introduction. Acute kidney injury (AKI) occurs in up to 50% of patients
admitted to the intensive care units. Optimization of volume status is a
challenging step in management of AKI patients.
Methods. This study was conducted on 40 critically ill patients with
AKI. Patients were randomly divided into 2 groups: group A; volume
status was optimized by CVP/DCVP and group B; volume status was
optimized by passive leg raising (PLR) and fluid challenge induced
stroke volume variation (SVV) using echocardiography. Both..
is less effective
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