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0 0.5 1 1.5 2+ Mortality 19% Improvement Relative Risk Yüksel et al. Vitamin C for COVID-19 ICU PATIENTS Is very late treatment with vitamin C beneficial for COVID-19? PSM retrospective 86 patients in Turkey Lower mortality with vitamin C (p=0.037) Yüksel et al., Intensive Care Medicine Experimen.., doi:10.1186/s40635-021-00413-8 Favors vitamin C Favors control

Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19; multi-center retrospective study

Yüksel et al., Intensive Care Medicine Experimental, 9:S1, 001458, doi:10.1186/s40635-021-00413-8 (Preprint)
Yüksel et al., Effects of high dose vitamin c on patient outcomes in ARDS patients admitted to intensive care with COVID-19;.., Intensive Care Medicine Experimental, 9:S1, 001458, doi:10.1186/s40635-021-00413-8 (Preprint)
Sep 2020   Source   PDF  
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PSM retrospective 86 ICU patients on mechanical ventilation in Turkey, showing lower mortality with high dose vitamin C treatment (≥200mg/kg for 4 days).
This is the 3rd of 61 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000098. 15 studies are RCTs, which show efficacy with p=0.00013.
risk of death, 18.8% lower, RR 0.81, p = 0.04, treatment 31 of 42 (73.8%), control 40 of 44 (90.9%), NNT 5.8, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Yüksel et al., 20 Sep 2020, retrospective, Turkey, preprint, 13 authors.
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Abstract: ICMx 2021, 9(Suppl 1):51 MEETING ABSTRACTS Intensive Care Medicine Experimental Open Access ESICM LIVES 2021: Part 1 Virtual 03-06 October 2021 Published: 11 October 2021 Best Oral Presentations 1 000100 High‑Protein Intake and Early Exercise in Adult Intensive Care Patients: A Randomized Controlled Phase III Study to Evaluate the Impact on Functional Outcomes J. ­Azevedo1; H. ­Lima2; P. ­Frota1; I. ­Nogueira1; S. ­Souza3; E. ­Fernandes1 1 Intensive care unit, Hospital São Domingos, São Luís, Brazil; 2Icu, Hospital São Domingos, São Luís, Brazil; 3Intensive care unit, Hospital São Domingos, Sao Luis, Brazil Correspondence: J. Azevedo Intensive Care Medicine Experimental 2020, 9(1): 000100 Introduction. The optimal integration between adequate protein intake and exercise in critically ill patients may have an impact on short and long-term outcomes, but this hypothesis has not been tested in studies with good methodology. In the given context, we conducted a prospective randomized controlled trial to evaluate the efficacy of high protein intake and early exercise versus guidelines recommended protein intake and routine physiotherapy on outcome of critically ill patients. Methods. We randomized mechanically ventilated patients expected to stay in the intensive care unit (ICU) for at least 4 days. We used indirect calorimetry to determine energy expenditure and guide caloric provision to the patients randomized to the high protein and early exercise (HPE) group and the control group. Protein intakes were 2.0 g/ kg/day and 1.4 g/kg/day respectively; while the former was submitted to two daily sessions of cycle ergometry exercise, the latter received routine physiotherapy. We evaluated the primary outcome physical component summary (PCS) score at 3 and 6 months) and the secondary outcomes (handgrip strength at ICU discharge and ICU and hospital mortality). Results. We analyzed 181 patients in the HPE (87) and control (94) group. There was no significant difference between groups in relation to the calories received. However, the amount of protein received by the HPE group was significantly higher than that received by the control group (p < 0.0001). The PCS score was significantly higher in the HPE group at 3 months (p = 0.01) and 6 months (p = 0.01). The hospital mortality was expressively higher in the control group (p = 0.006). We found an independent association between age and 3-month PCS and that between age and group and 6-month PCS. Conclusion. This study showed that a high-protein intake and resistive exercise increase the survival rate and the physical quality of life of critically ill patients. 000160 Fluid Management In Critically Ill Patients With Acute Kidney Injury: Role Of Noninvasive Assessment of Stroke Volume H. ­Effat1 1 Critical Care Medicine, Cairo University, Cairo, Egypt Correspondence: H. Effat Intensive Care Medicine Experimental 2020, 9(1): 000160 Introduction. Acute kidney injury (AKI) occurs in up to 50% of patients admitted to the intensive care units. Optimization of volume status is a challenging step in management of AKI patients. Methods. This study was conducted on 40 critically ill patients with AKI. Patients were randomly divided into 2 groups: group A; volume status was optimized by CVP/DCVP and group B; volume status was optimized by passive leg raising (PLR) and fluid challenge induced stroke volume variation (SVV) using echocardiography. Both..
Late treatment
is less effective
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