Background: To assess the effectiveness of vitamin C treatment against coronavirus disease 2019 (COVID-19) Methods: An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received high-dose of vitamin C (six gr daily) added to the same regimen. Results: There were no statistically signi cant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. On the 3 rd day of hospitalization, the mean core body temperatures was signi cantly lower and SpO2 was higher In the case group (p value = 0.001, and 0.014, respectively). The median length of hospitalization in case group which was signi cantly longer than the control group (8.5 days vs. 6.5 days) (p value = 0.0280). There was no signi cant difference in SpO2 levels at discharge time, the length of ICU stay, and mortality between the two groups. Conclusions: We did not nd signi cantly better outcomes in the group who were treated with high-dose vitamin C in addition to the main treatment regimen at discharge. Trial registration: The project was registered by Iranian Registry of Clinical Trials.
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