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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 0% Improvement Relative Risk Ventilation -25% Hospitalization time -31% Vitamin C  JamaliMoghadamSiahkali et al.  LATE TREATMENT  RCT Is late treatment with vitamin C beneficial for COVID-19? RCT 60 patients in Iran (April - May 2020) Longer hospitalization with vitamin C (p=0.028) JamaliMoghadamSiahkali et al., Researc.., Jan 2021 Favors vitamin C Favors control

Safety and Effectiveness of High-Dose Vitamin C in Patients with COVID-19; A Randomized Controlled open-label Clinical Trial

JamaliMoghadamSiahkali et al., Research Square, doi:10.21203/
Jan 2021  
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Small late stage RCT for the addition of vitamin C to HCQ and lopinavir/ritonavir, with 30 treatment and 30 control patients, finding a significant reduction in temperature and a significant improvement in oxygenation after 3 days in the vitamin C group. However, hospitalization time was longer and there was no significant difference in mortality.
This is the 4th of 18 COVID-19 RCTs for vitamin C, which collectively show efficacy with p=0.00088.
This is the 11th of 66 COVID-19 controlled studies for vitamin C, which collectively show efficacy with p=0.00000029.
risk of death, no change, RR 1.00, p = 1.00, treatment 3 of 30 (10.0%), control 3 of 30 (10.0%).
risk of mechanical ventilation, 25.0% higher, RR 1.25, p = 1.00, treatment 5 of 30 (16.7%), control 4 of 30 (13.3%).
hospitalization time, 30.8% higher, relative time 1.31, p = 0.03, treatment 30, control 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
JamaliMoghadamSiahkali et al., 9 Jan 2021, Randomized Controlled Trial, Iran, preprint, 17 authors, study period April 2020 - May 2020.
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Background: To assess the effectiveness of vitamin C treatment against coronavirus disease 2019 (COVID-19) Methods: An open-label, randomized, and controlled trial was conducted on patients with severe COVID-19 infection. The case and control treatment groups each consisted of 30 patients. The control group received lopinavir/ritonavir and hydroxychloroquine and the case group received high-dose of vitamin C (six gr daily) added to the same regimen. Results: There were no statistically signi cant differences between two groups with respect to age and gender, laboratory results, and underlying diseases. On the 3 rd day of hospitalization, the mean core body temperatures was signi cantly lower and SpO2 was higher In the case group (p value = 0.001, and 0.014, respectively). The median length of hospitalization in case group which was signi cantly longer than the control group (8.5 days vs. 6.5 days) (p value = 0.0280). There was no signi cant difference in SpO2 levels at discharge time, the length of ICU stay, and mortality between the two groups. Conclusions: We did not nd signi cantly better outcomes in the group who were treated with high-dose vitamin C in addition to the main treatment regimen at discharge. Trial registration: The project was registered by Iranian Registry of Clinical Trials.
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Late treatment
is less effective
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