Conv. Plasma
Nigella Sativa

All propolis studies
Meta analysis
study COVID-19 treatment researchPropolisPropolis (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

The influence of propolis plus Hyoscyamus niger L. against COVID‐19: A phase II, multicenter, placebo‐controlled, randomized trial

Kosari et al., Phytotherapy Research, doi:10.1002/ptr.8047, IRCT20200516047462N1
Nov 2023  
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 86% Improvement Relative Risk ICU admission 86% Recovery 64% Propolis  Kosari et al.  LATE TREATMENT  DB RCT Is late treatment with propolis + Hyoscyamus niger L. beneficial for COVID-19? Double-blind RCT 140 patients in Iran Improved recovery with propolis + Hyoscyamus niger L. (p=0.0068) Kosari et al., Phytotherapy Research, Nov 2023 Favorspropolis Favorscontrol 0 0.5 1 1.5 2+
RCT 140 patients showing lower progression and improved recovery with propolis plus Hyoscyamus niger L.syrup.
risk of death, 85.7% lower, RR 0.14, p = 0.24, treatment 0 of 70 (0.0%), control 3 of 70 (4.3%), NNT 23, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 6.
risk of ICU admission, 85.7% lower, RR 0.14, p = 0.06, treatment 1 of 70 (1.4%), control 7 of 70 (10.0%), NNT 12.
risk of no recovery, 63.6% lower, RR 0.36, p = 0.007, treatment 8 of 70 (11.4%), control 22 of 70 (31.4%), NNT 5.0, day 6.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kosari et al., 22 Nov 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 15 authors, this trial uses multiple treatments in the treatment arm (combined with Hyoscyamus niger L.) - results of individual treatments may vary, trial IRCT20200516047462N1. Contact:
This PaperPropolisAll
{ 'indexed': {'date-parts': [[2024, 1, 21]], 'date-time': '2024-01-21T05:05:29Z', 'timestamp': 1705813529148}, 'reference-count': 43, 'publisher': 'Wiley', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2023, 11, 22]], 'date-time': '2023-11-22T00:00:00Z', 'timestamp': 1700611200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': ''}], 'content-domain': {'domain': [''], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 1]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>The incubation period of COVID‐19 symptoms, along ' 'with the proliferation and high transmission rate of the SARS‐CoV‐2 virus, is the cause of an ' 'uncontrolled epidemic worldwide. Vaccination is the front line of prevention, and ' 'antiinflammatory and antiviral drugs are the treatment of this disease. In addition, some ' 'herbal therapy approaches can be a good way to deal with this disease. The aim of this study ' 'was to evaluate the effect of propolis syrup with <jats:italic>Hyoscyamus niger</jats:italic> ' 'L. extract in hospitalized patients with COVID‐19 with acute disease conditions in a ' 'double‐blinded approach. The study was performed on 140 patients with COVID‐19 in a ' 'double‐blind, randomized, and multicentral approach. The main inclusion criterion was the ' 'presence of a severe type of COVID‐19 disease. The duration of treatment with syrup was ' '6\u2009days and 30\u2009CC per day in the form of three meals. On Days 0, 2, 4, and 6, ' 'arterial blood oxygen levels, C‐reactive protein (CRP), erythrocyte sedimentation rate, and ' "white blood cell, as well as the patient's clinical symptoms such as fever and chills, cough " 'and shortness of breath, chest pain, and other symptoms, were recorded and analyzed. Propolis ' 'syrup with <jats:italic>H. niger</jats:italic> L. significantly reduces cough from the second ' 'day, relieving shortness of breath on the fourth day, and significantly reduces CRP, ' 'weakness, and lethargy, as well as significantly increased arterial blood oxygen pressure on ' 'the sixth day compared to the placebo group (<jats:italic>p</jats:italic>\u2009&lt;\u2009' '0.05). The results in patients are such that in the most severe conditions of the disease ' '80%\u2009&lt;\u2009SpO<jats:sub>2</jats:sub> (oxygen saturation), the healing process of the ' 'syrup on reducing CRP and increasing arterial blood oxygen pressure from the fourth day is ' 'significantly different compared with the placebo group (<jats:italic>p</jats:italic>\u2009' '&lt;\u20090.05). The use of syrup is associated with a reduction of 3.6\u2009days in the ' 'hospitalization period compared with the placebo group. Propolis syrup with <jats:italic>H. ' 'niger</jats:italic> L. has effectiveness in the viral and inflammatory phases on clinical ' 'symptoms and blood parameters and arterial blood oxygen levels of patients with COVID‐19. ' 'Also, it reduces referrals to the intensive care unit and mortality in hospitalized patients ' 'with COVID‐19. So, this syrup promises to be an effective treatment in the great challenge of ' 'COVID‐19.</jats:p>', 'DOI': '10.1002/ptr.8047', 'type': 'journal-article', 'created': { 'date-parts': [[2023, 11, 24]], 'date-time': '2023-11-24T16:23:39Z', 'timestamp': 1700843019000}, 'page': '400-410', 'update-policy': '', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'The influence of propolis plus <i>Hyoscyamus niger</i> L. against <scp>COVID</scp>‐19: A phase ' '<scp>II</scp>, multicenter, placebo‐controlled, randomized trial', 'prefix': '10.1002', 'volume': '38', 'author': [ { 'given': 'Morteza', 'family': 'Kosari', 'sequence': 'first', 'affiliation': [ { 'name': 'Physiology Research Center, Institute for Basic Sciences Kashan ' 'University of Medical Sciences Kashan Iran'}, { 'name': 'Department of Biology, Science and Research Branch Islamic Azad ' 'University Tehran Iran'}]}, { 'given': 'Farzin', 'family': 'Khorvash', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Disease, Medical School Isfahan ' 'University of Medical Science Isfahan Iran'}, { 'name': 'Nosocomial Infection Research Center Isfahan University of ' 'Medical Sciences Isfahan Iran'}]}, { 'given': 'Mohammad Kazem', 'family': 'Sayyah', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases Research Center Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Maryam', 'family': 'Ansari Chaharsoughi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases, Infectious Diseases and ' 'Tropical Medicine Research Center Isfahan University of Medical ' 'Sciences Isfahan Iran'}]}, { 'given': 'Ahmad', 'family': 'Najafi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases Research Center Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Mansooreh', 'family': 'Momen‐Heravi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Infectious Diseases Research Center Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Mohammad', 'family': 'Karimian', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Molecular and Cell Biology, Faculty of Basic ' 'Sciences University of Mazandaran Babolsar Iran'}]}, { 'given': 'Hossein', 'family': 'Akbari', 'sequence': 'additional', 'affiliation': [ { 'name': 'Social Determinants of Health Research Center, Department of ' 'Biostatistics and Epidemiology, School of Public Health Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Mehdi', 'family': 'Noureddini', 'sequence': 'additional', 'affiliation': [ { 'name': 'Physiology Research Center, Institute for Basic Sciences Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Mahmoud', 'family': 'Salami', 'sequence': 'additional', 'affiliation': [ { 'name': 'Physiology Research Center, Institute for Basic Sciences Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Amir', 'family': 'Ghaderi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Addiction Studies, School of Medical, Clinical ' 'Research Development Unit‐Matini/Kargarnejad Hospital Kashan ' 'University of Medical Sciences Kashan Iran'}]}, { 'given': 'Javad', 'family': 'Amini Mahabadi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Anatomical Research Center Kashan University of Medical ' 'Sciences Kashan Iran'}, { 'name': "Sarem Fertility and Infertility Research Center, Sarem Women's " 'Hospital Iran University of Medical Sciences (IUMS) Tehran ' 'Iran'}, {'name': "Sarem Cell Research Center Sarem Women's Hospital Tehran Iran"}]}, { 'given': 'Seyed Peyman', 'family': 'Khamechi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Persian Medicine School of Persian Medicine, ' 'Tehran University of Medical Sciences Tehran Iran'}]}, { 'given': 'Somayeh', 'family': 'Yeganeh', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Mathematical Sciences Isfahan University of ' 'Technology Isfahan Iran'}]}, { 'ORCID': '', 'authenticated-orcid': False, 'given': 'Hamid Reza', 'family': 'Banafshe', 'sequence': 'additional', 'affiliation': [ { 'name': 'Physiology Research Center, Institute for Basic Sciences Kashan ' 'University of Medical Sciences Kashan Iran'}, { 'name': 'Department of Pharmacology, School of Medicine Kashan University ' 'of Medical Sciences Kashan Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 11, 22]]}, 'reference': [ {'key': 'e_1_2_11_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/molecules26051232'}, {'key': 'e_1_2_11_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.15252/emmm.202013038'}, {'key': 'e_1_2_11_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/nu11112705'}, { 'key': 'e_1_2_11_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1513/AnnalsATS.202008-940OC'}, {'key': 'e_1_2_11_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41598-022-05832-5'}, {'key': 'e_1_2_11_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2001282'}, { 'key': 'e_1_2_11_8_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1513/AnnalsATS.202005-478SD'}, {'key': 'e_1_2_11_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41467-021-27797-1'}, {'key': 'e_1_2_11_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.12788/jhm.3560'}, {'key': 'e_1_2_11_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1128/AAC.01897-20'}, { 'key': 'e_1_2_11_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.pharmthera.2020.107745'}, { 'key': 'e_1_2_11_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(21)02753-7'}, { 'key': 'e_1_2_11_14_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.202009-3533SO'}, { 'key': 'e_1_2_11_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(20)30183-5'}, { 'key': 'e_1_2_11_16_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.202005-1885OC'}, { 'key': 'e_1_2_11_17_1', 'article-title': 'Chemical compositions of essential oils, antimicrobial effect and ' 'antioxidant activity studies of Hyoscyamus niger L. from Turkey', 'author': 'İnci Ş.', 'year': '2022', 'journal-title': 'bioRxiv'}, {'key': 'e_1_2_11_18_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3947/ic.2020.52.2.212'}, {'key': 'e_1_2_11_19_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2016/4156293'}, { 'key': 'e_1_2_11_20_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00705-022-05545-0'}, {'key': 'e_1_2_11_21_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.7116'}, { 'key': 'e_1_2_11_22_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41467-022-28068-3'}, { 'key': 'e_1_2_11_23_1', 'article-title': 'Clinical spectrum of severe acute respiratory syndrome coronavirus 2 ' 'infection and protection from symptomatic reinfection', 'volume': '75', 'author': 'Maier H. E.', 'year': '2021', 'journal-title': 'Clinical Infectious Diseases'}, {'key': 'e_1_2_11_24_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3389/fphar.2021.583387'}, { 'key': 'e_1_2_11_25_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jsbmb.2019.105573'}, { 'key': 'e_1_2_11_26_1', 'first-page': '22', 'article-title': 'Effect of propolis on moderate persistent asthma: A phase two ' 'randomized, double blind, controlled clinical trial', 'volume': '11', 'author': 'Mirsadraee M.', 'year': '2021', 'journal-title': 'Avicenna Journal of Phytomedicine'}, {'key': 'e_1_2_11_27_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/rmv.2221'}, { 'key': 'e_1_2_11_28_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.xcrm.2020.100144'}, {'key': 'e_1_2_11_29_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41590-017-0006-x'}, { 'key': 'e_1_2_11_30_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(21)02392-8'}, { 'key': 'e_1_2_11_31_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S0140-6736(21)01825-0'}, { 'key': 'e_1_2_11_32_1', 'first-page': '3140', 'article-title': 'Case report: C‐reactive protein apheresis in a patient with COVID‐19 ' 'and fulminant CRP increase', 'volume': '21', 'author': 'Ringel J.', 'year': '2021', 'journal-title': 'Frontiers in Immunology'}, {'key': 'e_1_2_11_33_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/jpp/rgaa067'}, { 'key': 'e_1_2_11_34_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s11356-019-07458-z'}, { 'key': 'e_1_2_11_35_1', 'article-title': 'Efficacy of propolis as an adjunct treatment for hospitalized COVID‐19 ' 'patients: A randomized, controlled clinical trial', 'author': 'Silveira M. A. D.', 'year': '2021', 'journal-title': 'MedRxiv'}, { 'key': 'e_1_2_11_36_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.202105-1302OC'}, { 'key': 'e_1_2_11_37_1', 'article-title': 'Signs and symptoms to determine if a patient presenting in primary care ' 'or hospital outpatient settings has COVID‐19', 'volume': '7', 'author': 'Struyf T.', 'year': '2022', 'journal-title': 'Cochrane Database of Systematic Reviews'}, { 'key': 'e_1_2_11_38_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1513/AnnalsATS.202011-1376CME'}, {'key': 'e_1_2_11_39_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1155/2019/4836378'}, { 'key': 'e_1_2_11_40_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.arcmed.2020.06.007'}, { 'key': 'e_1_2_11_41_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.scitotenv.2020.138277'}, { 'key': 'e_1_2_11_42_1', 'volume-title': 'Living guidance for clinical management of COVID‐19: Living guidance, 23 ' 'November 2021', 'author': 'World Health Organization', 'year': '2021'}, { 'key': 'e_1_2_11_43_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s42003-020-01190-y'}, { 'key': 'e_1_2_11_44_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/14786419.2013.805331'}], 'container-title': 'Phytotherapy Research', 'original-title': [], 'language': 'en', 'link': [ { 'URL': '', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 1, 21]], 'date-time': '2024-01-21T03:42:23Z', 'timestamp': 1705808543000}, 'score': 1, 'resource': {'primary': {'URL': ''}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 11, 22]]}, 'references-count': 43, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2024, 1]]}}, 'alternative-id': ['10.1002/ptr.8047'], 'URL': '', 'relation': {}, 'ISSN': ['0951-418X', '1099-1573'], 'subject': ['Pharmacology'], 'container-title-short': 'Phytotherapy Research', 'published': {'date-parts': [[2023, 11, 22]]}, 'assertion': [ { 'value': '2022-10-20', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2023-08-16', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2023-11-22', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop