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All Studies   Meta Analysis    Recent:   

Predictors of incident viral symptoms ascertained in the era of COVID-19

Marcus et al., PLOS ONE, doi:10.1371/journal.pone.0253120
Jun 2021  
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Symp. case 16% Improvement Relative Risk Sleep for COVID-19  Marcus et al.  Prophylaxis Is better sleep beneficial for COVID-19? Prospective study of 14,335 patients in multiple countries (Mar - May 2020) Fewer symptomatic cases with higher quality sleep (p=0.00075) c19early.org Marcus et al., PLOS ONE, June 2021 Favorsgood sleep Favorscontrol 0 0.5 1 1.5 2+
Sleep for COVID-19
16th treatment shown to reduce risk in March 2021
 
*, now with p = 0.0000000019 from 15 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Prospective survey based study with 14,335 participants, showing risk of viral symptoms associated with shorter sleep duration.
Study covers sleep and exercise.
risk of symptomatic case, 16.0% lower, OR 0.84, p < 0.001, adjusted per study, per extra hour sleep, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Marcus et al., 17 Jun 2021, prospective, multiple countries, peer-reviewed, survey, 12 authors, study period 26 March, 2020 - 3 May, 2020.
This PaperSleepAll
Predictors of incident viral symptoms ascertained in the era of COVID-19
Gregory M Marcus, Jeffrey E Olgin, Noah D Peyser, Eric Vittinghoff, Vivian Yang, Sean Joyce, Robert Avram, Geoffrey H Tison, David Wen, Xochitl Butcher, Helena Eitel, Mark J Pletcher
PLOS ONE, doi:10.1371/journal.pone.0253120
Background In the absence of universal testing, effective therapies, or vaccines, identifying risk factors for viral infection, particularly readily modifiable exposures and behaviors, is required to identify effective strategies against viral infection and transmission. Methods We conducted a world-wide mobile application-based prospective cohort study available to English speaking adults with a smartphone. We collected self-reported characteristics, exposures, and behaviors, as well as smartphone-based geolocation data. Our main outcome was incident symptoms of viral infection, defined as fevers and chills plus one other symptom previously shown to occur with SARS-CoV-2 infection, determined by daily surveys. Findings Among 14, 335 participants residing in all 50 US states and 93 different countries followed for a median 21 days (IQR 10-26 days), 424 (3%) developed incident viral symptoms. In pooled multivariable logistic regression models, female biological sex (odds ratio [OR] 1.75, 95% CI 1.39-2.20, p<0.001), anemia (OR 1.45, 95% CI 1.16-1.81, p = 0.001), hypertension (OR 1.35, 95% CI 1.08-1.68, p = 0.007), cigarette smoking in the last 30 days (OR 1.86, p<0.001), any viral symptoms among household members 6-12 days prior (OR 2.06, 95% CI 1.67-2.55, p<0.001), and the maximum number of individuals the participant interacted with within 6 feet in the past 6-12 days (OR 1.15, 95% CI 1.06-1.25, p<0.001) were each associated with a higher risk of developing viral symptoms. Conversely, a higher subjective social status (OR 0.87, 95% CI 0.83-0.93, p<0.001), at least weekly exercise (OR 0.57, 95% CI 0.47-0.70, p<0.001), and sanitizing one's phone (OR 0.79, 95% CI 0.63-0.99, p = 0.037) were each associated with a lower risk of developing viral symptoms.
Supporting information S1 Table. Proportion of participants completing at least one daily survey per week and the proportion completing weekly surveys. (DOCX) S2
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We collected self-reported characteristics, ' 'exposures, and behaviors, as well as smartphone-based geolocation data. Our main outcome was ' 'incident symptoms of viral infection, defined as fevers and chills plus one other symptom ' 'previously shown to occur with SARS-CoV-2 infection, determined by daily surveys.</jats:p>\n' '</jats:sec>\n' '<jats:sec id="sec003">\n' '<jats:title>Findings</jats:title>\n' '<jats:p>Among 14, 335 participants residing in all 50 US states and 93 different countries ' 'followed for a median 21 days (IQR 10–26 days), 424 (3%) developed incident viral symptoms. ' 'In pooled multivariable logistic regression models, female biological sex (odds ratio [OR] ' '1.75, 95% CI 1.39–2.20, p&lt;0.001), anemia (OR 1.45, 95% CI 1.16–1.81, p = 0.001), ' 'hypertension (OR 1.35, 95% CI 1.08–1.68, p = 0.007), cigarette smoking in the last 30 days ' '(OR 1.86, 95% CI 1.35–2.55, p&lt;0.001), any viral symptoms among household members 6–12 days ' 'prior (OR 2.06, 95% CI 1.67–2.55, p&lt;0.001), and the maximum number of individuals the ' 'participant interacted with within 6 feet in the past 6–12 days (OR 1.15, 95% CI 1.06–1.25, ' 'p&lt;0.001) were each associated with a higher risk of developing viral symptoms. 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Decreasing COVID-19 complications among ' 'Massachusetts healthcare workers: a cohort study', 'volume': '115', 'author': 'FY Lan', 'year': '2021', 'journal-title': 'Pathog Glob Health'}], 'container-title': ['PLOS ONE'], 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://dx.plos.org/10.1371/journal.pone.0253120', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2021, 6, 17]], 'date-time': '2021-06-17T17:37:59Z', 'timestamp': 1623951479000}, 'score': 1, 'resource': {'primary': {'URL': 'https://dx.plos.org/10.1371/journal.pone.0253120'}}, 'subtitle': [], 'editor': [{'given': 'Antonio', 'family': 'Palazón-Bru', 'sequence': 'first', 'affiliation': []}], 'short-title': [], 'issued': {'date-parts': [[2021, 6, 17]]}, 'references-count': 48, 'journal-issue': {'issue': '6', 'published-online': {'date-parts': [[2021, 6, 17]]}}, 'URL': 'http://dx.doi.org/10.1371/journal.pone.0253120', 'relation': {}, 'ISSN': ['1932-6203'], 'issn-type': [{'value': '1932-6203', 'type': 'electronic'}], 'subject': ['Multidisciplinary'], 'published': {'date-parts': [[2021, 6, 17]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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