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0 0.5 1 1.5 2+ Severe case 81% Improvement Relative Risk Sleep for COVID-19  Huang et al.  Prophylaxis Is better sleep beneficial for COVID-19? Retrospective 136 patients in China (February - March 2020) Lower severe cases with higher quality sleep (p=0.015) Huang et al., Nature and Science of Sl.., Nov 2021 Favors good sleep Favors control

Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19

Huang et al., Nature and Science of Sleep, doi:10.2147/NSS.S263488
Nov 2021  
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Sleep for COVID-19
15th treatment shown to reduce risk in March 2021
*, now known with p = 0.0000000019 from 15 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Retrospective 164 COVID-19 patients and 188 controls in China, showing the risk of severe cases associated with lack of sleep.
Study covers sleep and exercise.
risk of severe case, 80.9% lower, RR 0.19, p = 0.02, higher quality sleep 12 of 127 (9.4%), lower quality sleep 4 of 9 (44.4%), NNT 2.9, adjusted per study, inverted to make RR<1 favor higher quality sleep, odds ratio converted to relative risk, recommended vs. lack of sleep, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huang et al., 30 Nov 2021, retrospective, China, peer-reviewed, survey, 5 authors, study period 10 February, 2020 - 28 March, 2020. Contact:,
This PaperSleepAll
<p>Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19</p>
Baozhen Huang, Yanlin Niu, Weiguo Zhao, Pengtao Bao, Diangeng Li
Nature and Science of Sleep, doi:10.2147/nss.s263488
Background: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out. Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients. Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctoradministered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance. Results: Comparing sick and non-sick patients, we found that irregular exercise (P=0.004), sedentary lifestyle (P=0.010), and overexertion (P<0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138-21.181) times higher for potentially appropriate sleep (P=0.001) and peaking at 8.612 (95% CI=1.913-38.760) times higher for lack of sleep (P=0.005). Reduction in average daily sleep time significantly increased the likely severity (P=0.002). Discussion: Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19.
Abbreviations COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; RT-PCR, real-time reverse-transcription polymerase-chainreaction; CT, computed tomography; IPAQ, International Physical Activity Questionnaire; NSF, National Sleep Foundation; OR, odds ratio; CI, confidence interval; BMI, body mass index; MET, metabolic equivalent of task. Ethics Declarations The study complied with the Declaration of Helsinki and the ethical approval in this study was obtained from the Research and Ethics Committee of the Chinese PLA General Hospital (No. S2020-063-01). All patients involved in this study signed informed consent. Author Contributions Baozhen Huang and Yanlin Niu contributed the same in this study. All authors made substantial contributions to the conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed on the journal to which the article will be submitted; gave final approval of the version to be published; and agree to be accountable for all aspects of the work. Disclosure The authors declare that they have no conflict of interest for this work. Nature and Science of Sleep Dovepress
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