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0 0.5 1 1.5 2+ Severe case 47% unadjusted Improvement Relative Risk Severe case (b) 8% unadjusted Case 66% c19early.org/ex Huang et al. Exercise for COVID-19 Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 164 patients in China (February - March 2020) Fewer cases with higher activity levels (p=0.0035) Huang et al., Nature and Science of Sleep, doi:10.2147/NSS.S263488 Favors exercise Favors inactivity
Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19
Huang et al., Nature and Science of Sleep, doi:10.2147/NSS.S263488
Huang et al., Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19, Nature and Science of Sleep, doi:10.2147/NSS.S263488
Nov 2021   Source   PDF  
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Retrospective 164 COVID-19 patients and 188 controls in China, showing lower risk of cases with regular exercise.
risk of severe case, 46.8% lower, RR 0.53, p = 0.18, high activity levels 7 of 74 (9.5%), low activity levels 16 of 90 (17.8%), NNT 12, unadjusted, exercise habit, ≥1 time per week, excluded in exclusion analyses: unadjusted results with no group details.
risk of severe case, 8.0% lower, RR 0.92, p = 1.00, high activity levels 3 of 23 (13.0%), low activity levels 20 of 141 (14.2%), NNT 88, unadjusted, ≥30 minutes ≥3 times per week, excluded in exclusion analyses: unadjusted results with no group details.
risk of case, 65.9% lower, OR 0.34, p = 0.004, adjusted per study, inverted to make OR<1 favor high activity levels, case control OR, regular exercise, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huang et al., 30 Nov 2021, retrospective, China, peer-reviewed, survey, 5 authors, study period 10 February, 2020 - 28 March, 2020.
Contact: lidiangeng@126.com, bao03@163.com.
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Abstract: Nature and Science of Sleep Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Nature and Science of Sleep For personal use only. Reduced Sleep in the Week Prior to Diagnosis of COVID-19 is Associated with the Severity of COVID-19 This article was published in the following Dove Press journal: Nature and Science of Sleep Baozhen Huang 1 Yanlin Niu 2 Weiguo Zhao 3 Pengtao Bao 4 Diangeng Li 1,5 1 Nanlou Respiratory Diseases Department, 2nd Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Beijing Center for Disease Prevention and Control, Institute for Nutrition and Food Hygiene, Beijing, People’s Republic of China; 3Department of Respiratory Medicine, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, The Eighth Medical Center of Chinese, Beijing, People’s Republic of China; 5 Department of Nephrology, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, People’s Republic of China Background: The rapid outbreak of coronavirus disease 2019 (COVID-19) is a major health concern, in response to which widespread risk factor research is being carried out. Objective: To discover how physical activity and lifestyle affect the epidemic as well as the disease severity and prognosis of COVID-19 patients. Methods: This multicenter, retrospective cohort study included 203 adults infected with COVID-19 and 228 uninfected adults in three Chinese provinces, with 164 (80.7%) of the infected participants and 188 (82.5%) of the uninfected participants answering a doctoradministered telephone questionnaire on lifestyle. The binary logistic regression model and the ordinal logit model were used to observe relevance. Results: Comparing sick and non-sick patients, we found that irregular exercise (P=0.004), sedentary lifestyle (P=0.010), and overexertion (P<0.001) may be associated with the susceptibility to COVID-19. In symptomatic patients, using the recommended status as a reference, risk of severe infection increased with decreased sleep status, being 6.729 (95% CI=2.138–21.181) times higher for potentially appropriate sleep (P=0.001) and peak­ ing at 8.612 (95% CI=1.913–38.760) times higher for lack of sleep (P=0.005). Reduction in average daily sleep time significantly increased the likely severity (P=0.002). Discussion: Through further examination of damage of external lung organs, we found that lack of sleep affected not only disease severity but also prognosis. Based on these findings, the public should prioritize a healthy lifestyle and get adequate sleep in response to the outbreak. The study of life habits may bring new ideas for the prevention and treatment of COVID-19. Keywords: COVID-19, disease severity, sleep status, damage of external lung organs
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