Melatonin is significantly associated with survival of intubated COVID-19 patients

{ 'institution': [{'name': 'medRxiv'}], 'indexed': {'date-parts': [[2024, 2, 12]], 'date-time': '2024-02-12T16:43:45Z', 'timestamp': 1707756225932}, 'posted': {'date-parts': [[2020, 10, 18]]}, 'group-title': 'Health Informatics', 'reference-count': 19, 'publisher': 'Cold Spring Harbor Laboratory', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 10, 18]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Respiratory ' 'distress requiring intubation is the most serious complication associated with coronavirus ' 'disease 2019 ' '(COVID-19).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this ' 'retrospective study, we used survival analysis to determine whether or not mortality ' 'following intubation was associated with hormone exposure in patients treated at New York ' 'Presbyterian/ Columbia University Irving Medical Center. Here, we report the overall hazards ' 'ratio for each hormone for exposure before and after intubation for intubated and ' 'mechanically ventilated ' 'patients.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among the ' '189,987 patients, we identified 948 intubation periods across 791 patients who were diagnosed ' 'with COVID-19 or infected with SARS-CoV2 and 3,497 intubation periods across 2,981 patients ' 'who were not. Melatonin exposure after intubation was statistically associated with a ' 'positive outcome in COVID-19 (demographics and comorbidities adjusted HR: 0.131, 95% CI: ' '7.76E-02 - 0.223, p-value = 8.19E-14) and non-COVID-19 (demographics and comorbidities ' 'adjusted HR: 0.278, 95% CI: 0.142 - 0.542, p-value = 1.72E-04) intubated patients. ' 'Additionally, melatonin exposure after intubation was statically associated with a positive ' 'outcome in COVID-19 patients (demographics and comorbidities adjusted HR: 0.127, 95% CI: ' '6.01E-02 - 0.269, p-value = ' '7.15E-08).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Melatonin ' 'exposure after intubation is significantly associated with a positive outcome in COVID-19 and ' 'non-COVID-19 patients. Additionally, melatonin exposure after intubation is significantly ' 'associated with a positive outcome in COVID-19 patients requiring mechanical ventilation. ' 'While our models account for many covariates, including clinical history and demographics, it ' 'is impossible to rule out confounding or collider biases within our population. Further study ' 'into the possible mechanism of this observation is warranted.</jats:p></jats:sec>', 'DOI': '10.1101/2020.10.15.20213546', 'type': 'posted-content', 'created': { 'date-parts': [[2020, 10, 18]], 'date-time': '2020-10-18T18:55:13Z', 'timestamp': 1603047313000}, 'source': 'Crossref', 'is-referenced-by-count': 28, 'title': 'Melatonin is significantly associated with survival of intubated COVID-19 patients', 'prefix': '10.1101', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-2318-7184', 'authenticated-orcid': False, 'given': 'Vijendra', 'family': 'Ramlall', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6987-6412', 'authenticated-orcid': False, 'given': 'Jason', 'family': 'Zucker', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-2700-2597', 'authenticated-orcid': False, 'given': 'Nicholas', 'family': 'Tatonetti', 'sequence': 'additional', 'affiliation': []}], 'member': '246', 'reference': [ { 'key': '2020102113100579000_2020.10.15.20213546v1.1', 'unstructured': 'Johns Hopkins University. 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