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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 32% Improvement Relative Risk Mortality, day 30 47% c19early.org/u Al Sulaiman et al. Budesonide for COVID-19 ICU Favors budesonide Favors control
The Role of Inhaled Corticosteroids (ICS) in Critically Ill Patients With COVID-19: A Multicenter, Cohort Study
Al Sulaiman et al., Journal of Intensive Care Medicine, doi:10.1177/08850666211053548
10 Nov 2021    Source   PDF   Share   Tweet
Combined retrospective (Mar-Jun 2020) and prospective (until Mar 2021) study of 954 COVID+ ICU patients in Saudi Arabia, 68 treated with ICS (80% budesonide or budesonide/formoterol, 20% fluticasone/salmeterol), showing lower mortality with treatment, statistically significant for 30-day but not in-hospital mortality.
risk of death, 32.0% lower, HR 0.68, p = 0.13, treatment 30 of 64 (46.9%), control 31 of 64 (48.4%), adjusted per study, in-hospital mortality, propensity score matching, multivariable, Cox proportional hazards.
risk of death, 47.0% lower, HR 0.53, p = 0.03, treatment 25 of 65 (38.5%), control 29 of 65 (44.6%), adjusted per study, propensity score matching, multivariable, Cox proportional hazards, day 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al Sulaiman et al., 10 Nov 2021, prospective, Saudi Arabia, peer-reviewed, 80% of treatment patients used budesonide, mean age 61.4, 24 authors, study period 1 March, 2020 - 31 March, 2021.
Contact: alsulaimankh@hotmail.com.
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This PaperBudesonideAll
Late treatment
is less effective
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