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0 0.5 1 1.5 2+ Mortality 67% Improvement Relative Risk Oxygen time 33% Hospitalization time 26% Recovery time 37% Budesonide  Bhandari et al.  LATE TREATMENT Is late treatment with budesonide beneficial for COVID-19? Retrospective 120 patients in India Lower need for oxygen therapy (p=0.0092) and shorter hospitalization (p=0.023) Bhandari et al., Int. J. Scientific De.., Mar 2022 Favors budesonide Favors control

Effectiveness of Inhaled Steroids in Post COVID Cough

Bhandari et al., International Journal of Scientific Development and Research, 7:3
Mar 2022  
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Budesonide for COVID-19
18th treatment shown to reduce risk in April 2021
*, now known with p = 0.000025 from 14 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 120 hospitalized COVID-19 patients with persistent cough in India, showing faster resolution of cough, shorter duration of oxygen support, and shorter hospitalization with inhaled budesonide treatment compared to standard of care alone.
risk of death, 66.7% lower, RR 0.33, p = 1.00, treatment 0 of 60 (0.0%), control 1 of 60 (1.7%), NNT 60, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
oxygen time, 33.4% lower, relative time 0.67, p = 0.009, treatment mean 5.21 (±4.23) n=60, control mean 7.82 (±6.35) n=60.
hospitalization time, 26.3% lower, relative time 0.74, p = 0.02, treatment mean 6.54 (±4.87) n=60, control mean 8.87 (±6.12) n=60.
recovery time, 36.8% lower, relative time 0.63, p = 0.001, treatment mean 4.85 (±3.94) n=60, control mean 7.68 (±5.43) n=60, cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bhandari et al., 22 Mar 2022, retrospective, India, peer-reviewed, 3 authors.
This PaperBudesonideAll
Effectiveness of Inhaled Steroids in Post COVID Cough
Dr Sudhir Bhandari, Dr Ajeet Singh, Dr Govind Rankawat, Senior
Background: Coronavirus disease 2019 can leads to persistent cough which may need special attention for better compliance of patients. We aimed to discuss the effect of inhaled steroids (Budesonide) in treatment of post COVID persistent cough and to know role of inhaled steroids in early recovery of COVID-19 patients. Methods: This retrospective observational case-control study included a total of 120 admitted patients of COVID-19 complaining of persistent cough after exclusion of another known identifiable causes. 60 patients had history of inhaled steroids for treatment of persistent cough while another 60 patients treated with standard of care treatment taken as a control group. The patient's data concerning demography, clinical profile, severity of disease, duration of illness, oxygen support, and outcome were extracted from their medical records. All collected data were tabulated, compiled, and analyzed to establish the possible causality of pneumothorax. Results: Patients of both groups had matched demographic, clinical symptoms, and comorbid status. Patients treated with inhaled steroids along with standard of care treatment had significant fast recovery (4.85 ± 3.94 days) as compared to control group (7.68 ± 5.43 days) with P=0.0014. Patients of inhaled steroids group also had early wean off from oxygen support (5.21 v/s 7.82 days), early discharge from hospital (6.54 days' v/s 8.87 days), and lesser alleviation of COVID-19 symptoms (8.33% v/s 21.67%) with P<0.05 Conclusion: This study concluded that the inhaled budesonide along with standard of care treatment helpful to relieve post COVID persistent cough. Beside early relief in cough, inhaled steroids also useful in early withdrawal of oxygen support and early discharge from hospital.
Discussion: In this study, we evaluate the effectiveness of inhaled steroids in the treatment of persistent cough after COVID-19 infection. We also try to establish an association between use of inhaled steroids and recovery from post COVID Cough. This is a retrospective case-control observational study that includes an age-matched, gender-matched, disease severity matched and underlying chronic medical illness matched control group in order to avoid these confounding factors for pneumothorax. Explaining the exact association between COVID-19 and post COVID cough is more challenging. In this study, we found that the inhaled glucocorticoid budesonide, given for the persistent cough, might be an effective treatment for post infectious cough in COVID-19 infected patients. Inhaled budesonide is a simple, safe, well studied, inexpensive, and widely available treatment. This is also significantly helpful in in low-income and middle-income countries where the majority of currently approved COVID-19 treatments are unlikely to ever reach patients as a consequence of variable health-care systems (17) . Although systemic steroids are well documented for treatment of moderate to critical COVID-19 infection but their role is not approved for use in post infectious cough. Furthermore, inhaled budesonide could work as an adjunct to reduce pressure on health-care systems and symptomatically to felt better to patients. In this study, our eyes focused on inhaled budesonide because of the..
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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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