Retrospective 185 hospitalized COVID-19 patients in China, showing no significant difference in mortality with budesonide use in unadjusted results.
Targeted administration to the respiratory tract provides treatment directly
to the typical source of initial SARS-CoV-2 infection and replication, and
allows for rapid onset of action, higher local drug concentration, and reduced
systemic side effects (early treatment may be more beneficial).
This study is excluded in the after exclusion results of meta
analysis:
unadjusted results with no group details.
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risk of death, 10.8% higher, RR 1.11, p = 0.85, treatment 30 of 125 (24.0%), control 13 of 60 (21.7%).
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Yang et al., 31 Aug 2022, retrospective, China, peer-reviewed, median age 62.0, 12 authors, study period 1 January, 2020 - 29 February, 2020.
Contact:
2205603@tongji.edu.cn, 1220775601@qq.com, 29553185@qq.com.
The relationship between oxygen therapy, drug therapy, and COVID-19 mortality
Ling Yang, Guoxi Chen, Yuyang Cai, Ye An, Xiaopan Li, Ying Chen, Cheng Xu, Chen Ji, Xing Lan, Yaling Wang, Hai Huang, Li Han
Open Medicine, doi:10.1515/med-2022-0569
Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 . We conducted a retrospective study of COVID-19 inpatients in Wuhan Pulmonary Hospital (Wuhan, China) from January 1 to February 29, 2020. The subjects were divided into four groups due to different treatment regimes. We used the Kaplan-Meier method to determine the cumulative rates of in-hospital death and the Cox proportional hazard model to calculate the risk factors and corresponding hazard ratios. A total of 185 patients were included in this study. The median age of the patients was 62 years, including 94 men and 91 women. Kaplan-Meier analysis demonstrated that mortality was higher in older patients, higher in men, and lower in the low-flow oxygen therapy group. Body mass index (BMI) had no influence on mortality, as well as high flow oxygen therapy, Lopinavir-ritonavir (LPV/r) therapy, and the interferon-alpha add LPV/r therapy. Cox proportional hazard regression confirmed that the low flow oxygen therapy was independent protective factor for in-hospital death after adjusting for age, gender, and BMI. In conclusion, the mortality was higher in older patients, higher in men, and lower in the low-flow oxygen therapy group. BMI had no influence on mortality, as well as high flow oxygen therapy, LPV/r therapy, and interferon-alpha add LPV/r therapy.
Abbreviations
Conflict of interest: The authors declare that they have no competing interest.
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