All Studies Meta Analysis

Protective Role of Inhaled Steroids for Covid-19 Infection

Taille et al., NCT04331054, INHASCO, NCT04331054

May 2021

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Budesonide for COVID-19

19th treatment shown to reduce risk in April 2021, now with p = 0.0000011 from 15 studies, recognized in 8 countries.

Lower risk for mortality, ICU, hospitalization, progression, recovery, and cases.

No treatment is 100% effective. Protocols combine treatments.

5,300+ studies for 115 treatments. c19early.org

146 patient budesonide late treatment RCT with results not reported over 3 years after completion.

4 budesonide RCTs have results missing long after expected1-4
The trials report a total of 916 patients, with 1 trial having actual enrollment of 146, and the remainder estimated.

Important missing comments or errors? Let us know.

1. Marcy et al., Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection: A Multi-Arm Multi-Stage Randomized Trial (MAMS) to Evaluate the Effectiveness of Several Specific Treatments in Reducing the Risk of Clinical Worsening or Death in Sub-Saharan Africa (COVERAGE-Africa), NCT04920838, clinicaltrials.gov/study/NCT04920838.clinicaltrials.gov.

2. Korea United Pharm., A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel, Phase 2 Study to Evaluate the Efficacy and Safety of UI030 in COVID-19 Patients, NCT05055414, clinicaltrials.gov/study/NCT05055414.clinicaltrials.gov.

3. Taille et al., Protective Role of Inhaled Steroids for Covid-19 Infection, NCT04331054, clinicaltrials.gov/study/NCT04331054.clinicaltrials.gov.

4. Afazeli et al., Evaluation of Efficacy of Pharmacotherapy Treatment of COVID-19 Infection Using Oral Levamisole and Formoterol+Budesonide Inhaler and Comparison of This Treatment Protocol With Standard National Treatment of the Disease, NCT04331470, clinicaltrials.gov/study/NCT04331470.clinicaltrials.gov.

Taille et al., 28 May 2021, Randomized Controlled Trial, France, trial NCT04331054 (history) (INHASCO).

This Paper Budesonide All

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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