COPD patients with high blood eosinophil counts exhibit a lower rate of omicron infection and milder post‐infection symptoms

{ 'indexed': {'date-parts': [[2024, 6, 1]], 'date-time': '2024-06-01T00:25:31Z', 'timestamp': 1717201531582}, 'reference-count': 28, 'publisher': 'Wiley', 'issue': '6', 'license': [ { 'start': { 'date-parts': [[2024, 5, 30]], 'date-time': '2024-05-30T00:00:00Z', 'timestamp': 1717027200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'doi-asserted-by': 'publisher', 'award': ['82000053']}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 6]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The ' 'emergence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its ' 'subsequent Omicron variant has raised concerns for chronic obstructive pulmonary disease ' '(COPD) patients due to the potential risk of disruptions to healthcare services and unknown ' 'comorbidities between COPD and ' 'Omicron.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>In this study, ' 'we conducted a follow‐up investigation of 315 COPD patients during the Omicron outbreak at ' 'Shanxi Bethune Hospital to understand the impact of the pandemic on this vulnerable ' 'population. Among all patients, 228 were infected with Omicron, of which 82 needed ' 'hospitalizations.</jats:p></jats:sec><jats:sec><jats:title>Result</jats:title><jats:p>We ' 'found that COPD patients with high blood eosinophil (EOS) counts exhibited lower ' 'susceptibility to Omicron infection and were more likely to have milder symptoms that did not ' 'require hospitalization. Conversely, patients with low EOS counts showed higher rates of ' 'infection and hospitalization. Moreover, EOS count was positively correlated with T ' 'lymphocyte counts in hospitalized patients after Omicron infection, suggesting potential ' 'associations between EOS and specific immune responses in COPD patients during viral ' 'infections. Correlation analysis revealed a positive correlation between EOS count and ' 'lymphocyte and T‐cells, and a negative correlation between EOS count and age, neutrophil, and ' 'C‐reactive ' 'protein.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Overall, our ' 'study contributes to the knowledge of COPD management during the COVID‐19 Omicron outbreak ' 'and emphasizes the importance of considering individual immune profiles to improve care for ' 'COPD patients in the face of the ongoing global health crisis.</jats:p></jats:sec>', 'DOI': '10.1111/crj.13790', 'type': 'journal-article', 'created': {'date-parts': [[2024, 5, 31]], 'date-time': '2024-05-31T06:04:14Z', 'timestamp': 1717135454000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'COPD patients with high blood eosinophil counts exhibit a lower rate of omicron infection and ' 'milder post‐infection symptoms', 'prefix': '10.1111', 'volume': '18', 'author': [ { 'given': 'Xueli', 'family': 'Bai', 'sequence': 'first', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}, { 'given': 'Yanan', 'family': 'Niu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}, { 'given': 'Shuang', 'family': 'Wei', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}, { 'name': 'Tongji Hospital, Tongji Medical College Huazhong University of ' 'Science and Technology Wuhan China'}]}, { 'given': 'Zhifan', 'family': 'Zhu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}, { 'given': 'Min', 'family': 'Xu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}, { 'given': 'Hu', 'family': 'Liu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}, { 'given': 'Xiansheng', 'family': 'Liu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}, { 'name': 'Tongji Hospital, Tongji Medical College Huazhong University of ' 'Science and Technology Wuhan China'}]}, { 'ORCID': 'http://orcid.org/0000-0001-6224-8480', 'authenticated-orcid': False, 'given': 'Ruiying', 'family': 'Wang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Third Hospital of Shanxi Medical University, Shanxi Bethune ' 'Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi ' 'Hospital Taiyuan China'}]}], 'member': '311', 'published-online': {'date-parts': [[2024, 5, 30]]}, 'reference': [ {'key': 'e_1_2_11_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa032158'}, { 'key': 'e_1_2_11_3_1', 'volume-title': 'Chronic Respiratory Diseases, Burden of Chronic Obstructive Pulmonary ' 'Disease', 'author': 'Organisation, W.H', 'year': '2015'}, {'key': 'e_1_2_11_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.201201‐0034OC'}, { 'key': 'e_1_2_11_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213‐2600(12)70060‐7'}, {'key': 'e_1_2_11_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/09031936.00078714'}, {'key': 'e_1_2_11_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/resp.12642'}, {'key': 'e_1_2_11_8_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.201108‐1553OC'}, { 'key': 'e_1_2_11_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/13993003.04590‐2020'}, {'key': 'e_1_2_11_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1056/NEJMoa2002032'}, { 'key': 'e_1_2_11_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41392‐022‐00997‐x'}, { 'key': 'e_1_2_11_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1152/ajplung.00386.2021'}, { 'key': 'e_1_2_11_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S2213‐2600(20)30167‐3'}, { 'key': 'e_1_2_11_14_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/13993003.02108‐2020'}, { 'key': 'e_1_2_11_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/13993003.04474‐2020'}, { 'key': 'e_1_2_11_16_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/thoraxjnl‐2020‐215167'}, { 'key': 'e_1_2_11_17_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/17476348.2021.2011219'}, {'key': 'e_1_2_11_18_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/jpm12081295'}, { 'key': 'e_1_2_11_19_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1136/bmj.m1393', 'article-title': 'Covid‐19: increased demand for steroid inhalers causes “distressing” ' 'shortages', 'volume': '369', 'author': 'Mahase E', 'year': '2020', 'journal-title': 'BMJ'}, { 'key': 'e_1_2_11_20_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jiph.2020.07.014'}, {'key': 'e_1_2_11_21_1', 'doi-asserted-by': 'publisher', 'DOI': '10.2147/COPD.S392660'}, { 'key': 'e_1_2_11_22_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/13993003.01370‐2015'}, {'key': 'e_1_2_11_23_1', 'doi-asserted-by': 'publisher', 'DOI': '10.2147/COPD.S179734'}, { 'key': 'e_1_2_11_24_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.201708‐1684LE'}, {'key': 'e_1_2_11_25_1', 'doi-asserted-by': 'publisher', 'DOI': '10.18295/squmj.1.2022.001'}, {'key': 'e_1_2_11_26_1', 'doi-asserted-by': 'publisher', 'DOI': '10.2147/COPD.S312493'}, { 'key': 'e_1_2_11_27_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1183/23120541.00594‐2020'}, {'key': 'e_1_2_11_28_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1186/1465‐9921‐10‐113'}, { 'key': 'e_1_2_11_29_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1164/rccm.200410‐1332OC'}], 'container-title': 'The Clinical Respiratory Journal', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1111/crj.13790', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 5, 31]], 'date-time': '2024-05-31T06:04:18Z', 'timestamp': 1717135458000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1111/crj.13790'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 5, 30]]}, 'references-count': 28, 'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2024, 6]]}}, 'alternative-id': ['10.1111/crj.13790'], 'URL': 'http://dx.doi.org/10.1111/crj.13790', 'relation': {}, 'ISSN': ['1752-6981', '1752-699X'], 'subject': [], 'container-title-short': 'Clinical Respiratory J', 'published': {'date-parts': [[2024, 5, 30]]}, 'assertion': [ { 'value': '2023-11-09', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-05-11', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-05-30', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}