Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All budesonide studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchBudesonideBudesonide (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 58% Improvement Relative Risk Ventilation 65% Hospitalization 69% Cough score, day 7 29% Cough score, day 3 10% Budesonide  Samajdar et al.  LATE TREATMENT Is late treatment with budesonide + formoterol beneficial for COVID-19? Prospective study of 102 patients in India (January - June 2021) Improved recovery with budesonide + formoterol (p=0.0082) c19early.org Samajdar et al., Lung India, March 2023 Favors budesonide Favors control

Effectiveness of budesonide formoterol fixed-dose combination MDI in reducing cough symptoms in COVID-19 patients: A real-world evidence study

Samajdar et al., Lung India, doi:10.4103/lungindia.lungindia_268_22
Mar 2023  
  Post
  Facebook
Share
  Source   PDF   All   Meta
Budesonide for COVID-19
18th treatment shown to reduce risk in April 2021
 
*, now known with p = 0.000025 from 14 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Prospective study of 102 patients in India, showing improved recovery of cough with budesonide+formoterol. Authors note better results with earlier treatment. Budesonide 800mcg + formoterol 12mcg bid for 7 days.
Targeted administration to the respiratory tract provides treatment directly to the typical source of initial SARS-CoV-2 infection and replication, and allows for rapid onset of action, higher local drug concentration, and reduced systemic side effects (early treatment may be more beneficial).
risk of death, 58.4% lower, RR 0.42, p = 0.44, treatment 2 of 50 (4.0%), control 5 of 52 (9.6%), NNT 18.
risk of mechanical ventilation, 65.3% lower, RR 0.35, p = 0.62, treatment 1 of 50 (2.0%), control 3 of 52 (5.8%), NNT 27.
risk of hospitalization, 68.8% lower, RR 0.31, p = 0.07, treatment 3 of 50 (6.0%), control 10 of 52 (19.2%), NNT 7.6.
cough score, 29.4% lower, RR 0.71, p = 0.008, treatment mean 2.14 (±1.24) n=50, control mean 3.03 (±1.99) n=52, day 7.
cough score, 9.9% lower, RR 0.90, p = 0.10, treatment mean 4.66 (±1.42) n=50, control mean 5.17 (±1.65) n=52, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Samajdar et al., 3 Mar 2023, prospective, India, peer-reviewed, mean age 47.2, 6 authors, study period January 2021 - June 2021, this trial uses multiple treatments in the treatment arm (combined with formoterol) - results of individual treatments may vary. Contact: shambo_sa2001@yahoo.co.in.
This PaperBudesonideAll
Effectiveness of budesonide formoterol fixed-dose combination MDI in reducing cough symptoms in COVID-19 patients: A real-world evidence study
Shambosamrat Samajdar, Shatavisa Mukherjee, Saibal Moitra, Jyotirmoy Pal, Shashank Joshi, Santanukumar Tripathi
Lung India, doi:10.4103/lungindia.lungindia_268_22
Background: Cough is a wearisome and exasperating symptom affecting the daily life of the infected patient. Cough due to coronavirus disease 2019 (COVID-19) causes excessive morbidity in human populations globally. Apart from the morbidity associated with cough, it also enhances the transmission of this viral infection through droplets. Therefore, curbing cough is crucial to limit its spread. Patients often administer over-the-counter products and antitussive agents, which have no proven benefit. The present study was undertaken to find out if cough associated with COVID-19 and other indicative clinical outcomes is alleviated with a budesonide/formoterol fixed-dose combination (FDC) metered-dose inhaler (MDI). Materials and Methods: A prospective observational study was conducted in mild COVID-19 patients who presented with a cough score ≥8 at presentation. Patients who were initiated on ICS-LABA MDI were observed as group A and those who were not initiated on MDI were observed as Group B. Cough symptom score (at baseline and on day 3 and day 7), the incidence of hospital admission and/or death, and need for mechanical ventilation were documented. Prescribing patterns of anti-cough medications were also noted and analysed. Results: Compared to group B, a higher mean cough score reduction was noted for group A patients at day 3 and day 7 when compared to the baseline, and this was significant at P < 0.001. A significant negative correlation was also observed between mean latency of MDI initiation from the symptom onset and mean cough score reduction. Analysis of the proportion of patients prescribed medications to treat cough showed that overall, 10.78% did not require these, with a greater proportion in group A compared to group B. Conclusion: Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 who were treated with ICS-LABA MDI along with usual care benefitted significantly in terms of symptom reduction compared to usual care.
Ethical approval The study has been approved by the Ethics Committee vide letter no HREC-AARC/13. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.
References
Anderson, Formoterol: Pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator, Life Sci
Becker, Hom, Villasis-Keever, Der Wouden, Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis, Cochrane Database Syst Rev
Finney, Glanville, Farne, Aniscenko, Fenwick et al., Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon, J Allergy Clin Immunol
Footitt, Johnston, Cough and viruses in airways disease: Mechanisms, Pulm Pharmacol Ther
Freund-Michel, Birrell, Giembycz, Hele, Haj-Yahia et al., Beta(2)-agonists block tussive responses in pigs via an atypical cAMP-dependent pathway, Eur Respir J
Gibson, Saltos, Fakes, Acute anti-inflammatory effects of inhaled budesonide in asthma: A randomized controlled trial, Am J Respir Crit Care Med
Grant, Geoghegan, Arbyn, Mohammed, Mcguinness et al., The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries, PLoS One
Griesel, Wagner, Mikolajewska, Stegemann, Fichtner et al., Inhaled corticosteroids for the treatment of COVID-19, Cochrane Database Syst Rev
Hsu, Stone, Worsdell, Busst, Chung, Coughing frequency in patients with persistent cough: Assessment using a 24 hour ambulatory recorder, Eur Respir J
Jacoby, Virus-induced asthma attacks, JAMA
Jeon, Ko, Lee, Choi, Byun et al., Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs, Antimicrob Agents Chemother
Jintana, Prasertsopon, Puthavathana, Lerdsamran, Antiviral effect in association with anti-apoptosis and anti-autophagy of repurposing formoterol fumarate dihydrate on enterovirus A71-infected neuronal cells, Virus Res
Korn, Jerre, Brattsand, Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells, Eur Respir J
Lipworth, Kuo, Lipworth, Chan, Inhaled Corticosteroids and COVID-19, Am J Respir Crit Care Med
Mahmoudvand, Shokri, Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19, Scand J Immunol
Peters, Sajuthi, Deford, Christenson, Rios et al., NHLBI severe asthma research program-3 investigators. COVID-19-related genes in sputum cells in asthma: Relationship to demographic features and corticosteroids, Am J Respir Crit Care Med
Ramakrishnan, Nicolau, Jr, Langford, Mahdi et al., Inhaled budesonide in the treatment of early COVID-19 (STOIC): A phase 2, open-label, andomized controlled trial, Lancet Respir Med
Sulaiman, Aljuhani, Aamer, Shaya, Shaya et al., The role of inhaled corticosteroids (ICS) in critically Ill patients with COVID-19: A multicenter, cohort study, J Intensive Care Med
Wallin, Sandstrom, Soderberg, Howarth, Lundbäck et al., The effects of regular inhaled formoterol, budesonide and placebo on mucosal inflammation and clinical indices in mild asthma, Am J Respir Crit Care Med
Yamaya, Nishimura, Deng, Sugawara, Watanabe et al., Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HcoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells, Respir Investig
Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors formortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study, Lancet
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit