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Factores asociados a la muerte por COVID-19 en pacientes admitidos en un hospital público en Tacna, Perú

Hueda-Zavaleta et al., Revista Peruana de Medicina Experimental y Salud Pública, doi:10.17843/rpmesp.2021.382.7158
Jun 2021  
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Mortality 54% Improvement Relative Risk Colchicine  Hueda-Zavaleta et al.  LATE TREATMENT Is late treatment with colchicine beneficial for COVID-19? Retrospective 351 patients in Peru Lower mortality with colchicine (p=0.025) Hueda-Zavaleta et al., Revista Peruana.., Jun 2021 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
*, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments.
Retrospective 450 late stage (median oxygen saturation 86%) COVID+ hospitalized patients in Peru, showing lower mortality with colchicine treatment.
risk of death, 54.0% lower, HR 0.46, p = 0.03, treatment 10 of 50 (20.0%), control 109 of 301 (36.2%), NNT 6.2, adjusted per study, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hueda-Zavaleta et al., 10 Jun 2021, retrospective, Peru, peer-reviewed, 6 authors, dosage not specified.
This PaperColchicineAll
Factores asociados a la muerte por COVID-19 en pacientes admitidos en un hospital público en Tacna, Perú
Miguel Hueda-Zavaleta, Cesar Copaja-Corzo, Fabrizzio Bardales-Silva, Rodrigo Flores-Palacios, Luis Barreto-Rocchetti, Vicente A Benites-Zapata
Revista Peruana de Medicina Experimental y Salud Pública, doi:10.17843/rpmesp.2021.382.7158
Objective: To describe the clinical, laboratory and treatment characteristics of COVID-19 patients and to determine the factors associated with mortality during hospital stay. Materials and Methods: Retrospective cohort study of adult COVID-19 inpatients. The clinical, laboratory and treatment data were obtained from the medical records of patients from the Hospital Nivel III Daniel Alcides Carrión in Tacna. For the survival analysis we used the Cox proportional hazards model, and we calculated crude and adjusted hazard ratios (HR) with 95% confidence intervals (95% CI). Results: We evaluated 351 patients; 74.1% of them were men. The most common comorbidities were obesity (31.6%), hypertension (27.1%) and diabetes mellitus (24.5%). The median time of hospitalization was 8 days (IQR: 4-15). From the total of patients, 32.9% died during follow-up. The multivariate analysis showed an increased risk of dying associated with the following: age ≥65 years, HR = 3.55 (95% CI: 1.70-7.40); increase in lactate dehydrogenase >720 U/L, HR = 2.08 (95% CI: 1.34-3.22); and oxygen saturation less than 90%, mainly when it was less than 80%, HR = 4.07 (95% CI: 2.10-7.88). In addition, the use of colchicine during treatment showed a protective effect, HR = 0.46 (95% CI: 0.23-0.91). Conclusions: Risk factors for mortality due to COVID-19 included being older than 65 years, having oxygen saturation less than 90%, and elevated lactate dehydrogenase >720 U/L; colchicine treatment could improve the prognosis of patients.
Author contributions: MHZ and CCC conceived the research idea, wrote the article, and carried out the data analysis and interpretation. FBS, RFP and LBR participated in data collection and wrote the article. VABZ participated in data analysis and interpretation, statistical and technical advice, and critical revision of the article. All authors approved the final version of the manuscript. Conflict of interest: The authors deny any conflict of interest.
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Late treatment
is less effective
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