COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease

DOI record: { "DOI": "10.1093/mr/roac074", "ISSN": [ "1439-7595", "1439-7609" ], "URL": "http://dx.doi.org/10.1093/mr/roac074", "abstract": "<jats:title>ABSTRACT</jats:title>\n <jats:sec>\n <jats:title>Objectives</jats:title>\n <jats:p>To evaluate the impact of familial Mediterranean fever (FMF) features on the clinical course and outcomes of coronavirus disease 2019 (COVID-19) and clinical course of FMF after COVID-19.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>Consecutive FMF patients with COVID-19 were enrolled from three referral hospitals. Clinical features of FMF and detailed COVID-19 information were obtained from patient interviews and medical records.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>Seventy-three FMF patients were included in the study. 94.5% of patients had clinical symptoms of COVID-19. We found 24.7% hospitalization, 12.3% respiratory support, 4.1% intensive care unit admission, 6.8% complication, and 1.4% mortality rate in patients. The risk factors of hospitalization for respiratory support were male gender [OR: 7.167 (95% CI: 1.368–37.535)], greater age [OR: 1.067 (95% CI: 1.016–1.121)], and non-adherence to colchicine treatment before the infection [OR: 7.5 (95% CI: 1.348–41.722)]. One-third of patients had reported attacks after COVID-19. The patterns of triggered attacks were fever, peritonitis, pleuritis, transient arthritis, chronic knee mono-arthritis, and protracted febrile myalgia.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>FMF characteristics were not associated with worse outcomes of COVID-19. Colchicine non-adherence was the risk factor of hospitalization for oxygen support. The rate of FMF attacks after COVID-19 is prominently increased, with some of them being protracted and destructive.</jats:p>\n </jats:sec>", "author": [ { "ORCID": "http://orcid.org/0000-0001-9866-9797", "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "authenticated-orcid": false, "family": "Avanoglu Guler", "given": "Aslihan", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0001-9026-9641", "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology, Dokuz Eylul University , Izmir, Turkey" } ], "authenticated-orcid": false, "family": "Yuce Inel", "given": "Tuba", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology, Eskisehir Osmangazi University , Eskisehir, Turkey" } ], "family": "Kasifoglu", "given": "Timucin", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Internal Medicine, Gazi University , Ankara, Tukey" } ], "family": "Coskun", "given": "Cansu", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Karadeniz", "given": "Hazan", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Yildirim", "given": "Derya", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Bilici", "given": "Reyhan", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Satis", "given": "Hasan", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Kucuk", "given": "Hamit", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Haznedaroglu", "given": "Seminur", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Goker", "given": "Berna", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey" } ], "family": "Ozturk", "given": "Mehmet Akif", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology, Dokuz Eylul University , Izmir, Turkey" } ], "family": "Sari", "given": "Ismail", "sequence": "additional" }, { "affiliation": [ { "name": "Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, 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