COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease

{ 'indexed': {'date-parts': [[2022, 7, 27]], 'date-time': '2022-07-27T04:56:42Z', 'timestamp': 1658897802384}, 'reference-count': 26, 'publisher': 'Oxford University Press (OUP)', 'license': [ { 'start': { 'date-parts': [[2022, 7, 21]], 'date-time': '2022-07-21T00:00:00Z', 'timestamp': 1658361600000}, 'content-version': 'am', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/pages/standard-publication-reuse-rights'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>ABSTRACT</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Objectives</jats:title>\n' ' <jats:p>To evaluate the impact of familial Mediterranean fever (FMF) ' 'features on the clinical course and outcomes of coronavirus disease 2019 (COVID-19) and ' 'clinical course of FMF after COVID-19.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>Consecutive FMF patients with COVID-19 were enrolled from three ' 'referral hospitals. Clinical features of FMF and detailed COVID-19 information were obtained ' 'from patient interviews and medical records.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>Seventy-three FMF patients were included in the study. 94.5% of ' 'patients had clinical symptoms of COVID-19. We found 24.7% hospitalization, 12.3% respiratory ' 'support, 4.1% intensive care unit admission, 6.8% complication, and 1.4% mortality rate in ' 'patients. The risk factors of hospitalization for respiratory support were male gender [OR: ' '7.167 (95% CI: 1.368–37.535)], greater age [OR: 1.067 (95% CI: 1.016–1.121)], and ' 'non-adherence to colchicine treatment before the infection [OR: 7.5 (95% CI: 1.348–41.722)]. ' 'One-third of patients had reported attacks after COVID-19. The patterns of triggered attacks ' 'were fever, peritonitis, pleuritis, transient arthritis, chronic knee mono-arthritis, and ' 'protracted febrile myalgia.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>FMF characteristics were not associated with worse outcomes of ' 'COVID-19. Colchicine non-adherence was the risk factor of hospitalization for oxygen support. ' 'The rate of FMF attacks after COVID-19 is prominently increased, with some of them being ' 'protracted and destructive.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/mr/roac074', 'type': 'journal-article', 'created': {'date-parts': [[2022, 7, 21]], 'date-time': '2022-07-21T08:08:59Z', 'timestamp': 1658390939000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary ' 'disease', 'prefix': '10.1093', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-9866-9797', 'authenticated-orcid': False, 'given': 'Aslihan', 'family': 'Avanoglu Guler', 'sequence': 'first', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Rheumatology , Gazi ' 'University, Ankara, Turkey'}]}, { 'ORCID': 'http://orcid.org/0000-0001-9026-9641', 'authenticated-orcid': False, 'given': 'Tuba', 'family': 'Yuce Inel', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Rheumatology, Dokuz ' 'Eylul University , Izmir, Turkey'}]}, { 'given': 'Timucin', 'family': 'Kasifoglu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Rheumatology, ' 'Eskisehir Osmangazi University , Eskisehir, Turkey'}]}, { 'given': 'Cansu', 'family': 'Coskun', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Internal Medicine, ' 'Gazi University , Ankara, Tukey'}]}, { 'given': 'Hazan', 'family': 'Karadeniz', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Rheumatology , Gazi ' 'University, Ankara, Turkey'}]}, { 'given': 'Derya', 'family': 'Yildirim', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Hospital, Department of Rheumatology , Gazi ' 'University, Ankara, Turkey'}]}, { 'given': 'Reyhan', 'family': 'Bilici', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine 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