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0 0.5 1 1.5 2+ Hospitalization -8% Improvement Relative Risk Case -12% Colchicine  Sáenz-Aldea et al.  Prophylaxis Is prophylaxis with colchicine beneficial for COVID-19? Retrospective 86,692 patients in Spain No significant difference in outcomes seen Sáenz-Aldea et al., J. Medical Virology, Jan 2023 Favors colchicine Favors control

Colchicine and risk of hospitalisation due to COVID-19: a population-based study

Sáenz-Aldea et al., Journal of Medical Virology, doi:10.1002/jmv.28496
Jan 2023  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
*, now known with p = 0.00000056 from 50 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 86,652 patients in Spain, showing no significant difference in cases and hospitalization with colchicine use. The different risk for patients prescribed colchicine may not be fully adjusted for. See
risk of hospitalization, 8.0% higher, OR 1.08, p = 0.68, treatment 36 of 3,060 (1.2%) cases, 459 of 56,785 (0.8%) controls, case control OR.
risk of case, 12.0% higher, OR 1.12, p = 0.68, treatment 140 of 29,817 (0.5%) cases, 459 of 56,875 (0.8%) controls, NNT 9.0, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sáenz-Aldea et al., 13 Jan 2023, retrospective, Spain, peer-reviewed, 8 authors. Contact:
This PaperColchicineAll
Colchicine and risk of hospitalization due to COVID‐19: A population‐based study
María Sáenz‐aldea, Ángel Salgado‐barreira, Margarita Taracido Trunk, María Piñeiro‐lamas, Maria T Herdeiro, Manuel Portela‐romero, Marc Saez, Adolfo Figueiras
Journal of Medical Virology, doi:10.1002/jmv.28496
Colchicine is one of the most widely studied and best-known anti-inflammatory treatments. This study aimed to assess the effect of colchicine on risk of hospitalization due to COVID-19; and its effect on susceptibility to and severity of the virus in patients with COVID-19. We carried out a population-based casecontrol study. The following groups were applied: (1) to assess risk of hospitalization, cases were patients with a positive PCR who were hospitalized due to COVID-19, and controls without a positive PCR; (2) to assess susceptibility to COVID-19, cases were patients with a positive PCR (hospitalized and non-hospitalized), and the same controls; (3) to determine potential severity, cases were subjects with COVID-19 hospitalized, and controls patients with COVID-19 nonhospitalised. Different electronic, linked, administrative health and clinical databases were used to extract data on sociodemographic variables, comorbidities, and medications dispensed. The study covered 3060 subjects with a positive PCR who were hospitalized, 26 757 with a positive PCR who were not hospitalized, and 56 785 healthy controls. After adjustment for sociodemographic variables, comorbidities and other treatments, colchicine did not modify risk of hospitalization due to COVID-19 (adjusted odd ratio [OR] 1.08 [95% confidence interval (CI) 0.76−1.53]), patients' susceptibility to contracting the disease (adjusted OR 1.12 (95% CI 0.91−1.37)) or the severity of the infection (adjusted OR 1.03 [95% CI 0.67−1.59]). Our results would neither support the prophylactic use of colchicine for prevention of the infection or hospitalization in any type of patient, nor justify the withdrawal of colchicine treatment due to a higher risk of contracting COVID-19.
00470" project (cofunded by the European Regional Development Fund, "A way to make Europe"). CONFLICT OF INTEREST The authors declare no conflict of interest. ETHICS STATEMENT The study was approved by the Galician Clinical Research Ethics
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