Golpour et al. Colchicine for COVID-19 META ANALYSIS
The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019: Meta-analysis
Golpour et al.
The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019:..
International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211031763
Meta analysis of 10 studies showing significantly lower COVID-19 mortality with colchicine.
Currently there are
48 colchicine studies
and meta analysis shows:
Golpour et al., 10 Jul 2021, peer-reviewed, 7 authors.
IJI0010.1177/20587384211031763International Journal of Immunopathology and PharmacologyGolpour et al.
Letter to the Editor
The effectiveness of Colchicine
as an anti-inflammatory drug in
the treatment of coronavirus
disease 2019: Meta-analysis
International Journal of
Immunopathology and Pharmacology
Volume 35: 1–8
© The Author(s) 2021
Article reuse guidelines:
Monireh Golpour1 , Tahoora Mousavi2,
Mina Alimohammadi3, Ali Mosayebian3,
Mohammadreza Shiran4, Reza Alizadeh Navaei5
and Alireza Rafiei3
A recently discovered coronavirus, SARS-CoV-2, caused a global respiratory disease pandemic called COVID-19.
Many studies have shown the excessive activation of the innate immune response that leads to the adverse outcomes
of COVID-19, and anti-inflammatory drugs are very useful in the treatment and management of this infection. The
activities of Colchicine, one of the anti-inflammatory drugs, target several pathways related to excessive inflammation of
COVID-19. This study aimed to evaluate the efficacy of Colchicine in the treatment of COVID-19 using a meta-analysis
approach. Scopus, Pubmed, Google scholars, Web of Science, and Science direct were used to search all the randomized
controlled trials, case-control, and cross-sectional studies that have evaluated the efficacy of Colchicine as a treatment
for COVID-19 (up to 28 May 2021). The overall effect of Colchicine versus the control group was determined using a
random-effects model meta-analysis where we compared changes (i.e. mean differences—Colchicine group vs Control
group) between the two conditions in test scores indicative of hospitalization time (day) and mortality rate. The results
illustrated Colchicine therapy is associated with a decreased mortality rate in COVID-19 patients and associated with
a decrease in hospitalization time (day) in COVID-19 patients. Present preliminary data shows that Colchicine has a
beneficial effect on coronavirus disease care in 2019. Therefore, Colchicine can be a good suggestion in the management
Colchicine, COVID-19, hospitalization time, mortality rate, anti-inflammatory
Date received: 4 February 2021; accepted: 16 June 2021
olecular and Cell Biology Research Center, Student Research
Committee, Faculty of Medicine, Mazandaran University of Medical
Science, Sari, Iran
Molecular and Cell Biology Research Center, Hemoglobinopathy
Research Institute, Mazandaran University of Medical Sciences, Sari,
Department of Immunology, School of Medicine, Mazandaran
University of Medical Sciences, Sari, Iran
epartment of Physiology and Pharmacology, School of Medicine,
Mazandaran University of Medical Sciences, Sari, Iran
Gastrointestinal Cancer Research Center, Non-Communicable Diseases
Institute, Mazandaran University of Medical Sciences, Sari, Iran
Alireza Rafiei, Mazandaran University of Medical Sciences, Sari
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