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Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis

Zein et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395
Jan 2022  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000018 from 53 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Systematic review and meta analysis showing that colchicine was associated with lower mortality in COVID-19 patients:
All studies: RR 0.66 [95%CI 0.53, 0.83], p < 0.001; I2: 42%
RCTs: RR 0.81 [95%CI 0.54, 1.20], p = 0.29; I2: 10%
The RCT result is non-significant, but is highly affected by the very late stage RECOVERY trial, which is not generalizable to earlier usage.
10 meta analyses show significant improvements with colchicine for mortality Danjuma, Elshafei, Elshiwy, Golpour, Lien, Rai, Salah, Zein, oxygen therapy Elshiwy, hospitalization Kow, and severity Yasmin.
Currently there are 53 colchicine for COVID-19 studies, showing 29% lower mortality [19‑39%], 29% lower ventilation [-15‑56%], 31% lower ICU admission [4‑51%], 19% lower hospitalization [10‑27%], and 9% more cases [-8‑29%].
Zein et al., 12 Jan 2022, peer-reviewed, 2 authors.
This PaperColchicineAll
Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis
Ahmad Fariz Malvi Zamzam Zein, MD Wilson Matthew Raffaello
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
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