The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis
Lukito et al.,
The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and..,
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2020.11.006 (meta analysis)
Meta analysis of 9 studies showing lower mortality with metformin use.
Currently there are
61 metformin studies and meta analysis shows:
Lukito et al., 11 Nov 2020, peer-reviewed, 6 authors.
Abstract: Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14 (2020) 2177e2183
Contents lists available at ScienceDirect
Diabetes & Metabolic Syndrome: Clinical Research & Reviews
journal homepage: www.elsevier.com/locate/dsx
The Effect of Metformin Consumption on Mortality in Hospitalized
COVID-19 patients: a systematic review and meta-analysis
Antonia Anna Lukito a, *, 1, Raymond Pranata b, 1, Joshua Henrina c,
Michael Anthonius Lim a, Sherly Lawrensia d, Ketut Suastika e
a
Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia
RSUD Balaraja, Tangerang, Indonesia
d
Ken Saras General Hospital, Semarang, Indonesia
e
Head, Division of Endocrinology and Metabolism Department of Internal Medicine, Faculty of Medicine, Udayana University. Denpasar, Bali, Indonesia
Denpasar, Bali, Indonesia
b
c
a r t i c l e i n f o
a b s t r a c t
Article history:
Received 29 October 2020
Received in revised form
4 November 2020
Accepted 6 November 2020
Background and aims: Diabetes is one of the most common comorbidities, and it is associated with
poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed
that mortality was reduced in those who consume metformin compared to those who did not, and given
its low cost and widespread availability; metformin is an attractive and potential agent to mitigate
excessive risk in diabetic populations.
Methods: Several medical databases (Pubmed, EuropePMC, EBSCOhost, Proquest, Cochrane library) and
two health-science preprint servers (preprint.org and Medrxiv) were systematically searched for relevant literature.
Results: Nine studies with 10,233 subjects were included in the qualitative and quantitative synthesis.
Meta-analysis showed that metformin is associated with lower mortality in pooled non-adjusted model
(OR 0.45 [0.25, 0.81], p ¼ 0.008; I2: 63.9%, p ¼ 0.026) and pooled adjusted model (OR 0.64 [0.43, 0.97],
p ¼ 0.035; I2: 52.1%, p ¼ 0.064).
Conclusion: The analysis showed that metformin consumption was associated with lower mortality.
Randomized controlled trials are needed to confirm this finding.
© 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Keywords:
COVID-19
SARS-CoV-2
Diabetes melitus
Metformin
Mortality
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