Preadmission use of antidiabetic medications and mortality among patients with COVID-19 having type 2 diabetes: A meta-analysis
Nam Nhat Nguyen, Dung Si Ho, Hung Song Nguyen, Dang Khanh Ngan Ho, Hung-Yuan Li, Chia-Yuan Lin, Hsiao-Yean Chiu, Yang-Ching Chen
Metabolism, doi:10.1016/j.metabol.2022.155196
Background: Diabetes is an independent predictor of poor outcomes in patients with COVID-19. We compared the effects of the preadmission use of antidiabetic medications on the in-hospital mortality of patients with COVID-19 having type 2 diabetes. Methods: A systematic search of PubMed, EMBASE, Scopus and Web of Science databases was performed to include studies (except case reports and review articles) published until November 30, 2021. We excluded papers regarding in-hospital use of antidiabetic medications. We used a random-effects meta-analysis to calculate the pooled OR (95% CI) and performed a sensitivity analysis to confirm the robustness of the meta-analyses. Main findings: We included 61 studies (3,061,584 individuals), which were rated as having low risk of bias. The OR (95% CI) indicated some medications protective against COVID-related death, including metformin [0.54 (0.47-0.62), I 2 86%], glucagon-like peptide-1 receptor agonist (GLP-1RA) [0.51 (0.37-0.69), I 2 85%], and sodium-glucose transporter-2 inhibitor (SGLT-2i) [0.60 (0.40-0.88), I 2 91%]. Dipeptidyl peptidase-4 inhibitor , I 2 82%] and insulin [1.70 (1.33-2.19), I 2 97%] users were more likely to die during hospitalization. Sulfonylurea, thiazolidinedione, and alpha-glucosidase inhibitor were mortality neutral [0.92 (95% CI 0.83-1.01, I 2 44%), 0.90 (95% CI 0.71-1.14, I 2 46%), and 0.61 (95% CI 0.26-1.45, I 2 77%), respectively]. The sensitivity analysis indicated that our findings were robust. Conclusions: Metformin, GLP-1RA, and SGLT-2i were associated with lower mortality rate in patients with COVID-19 having type 2 diabetes. DPP-4i and insulin were linked to increased mortality. Sulfonylurea, thiazolidinedione, and alpha-glucosidase inhibitors were mortality neutral. These findings can have a large impact on the clinicians' decisions amid the COVID-19 pandemic.
Decreased Han et al. [5] Preadmission + in-hospital 20 0.62 (0.50-0.76) Decreased Hariyanto et al. [74] Preadmission 5 0.54 (0.32-0.90) Decreased Kan et al. [75] Preadmission + in-hospital 15 0.69 (0.55-0.86) Decreased Kow et al. [76] Preadmission 5 0.62 (0.43-0.89) Decreased Li et al. [77] Preadmission + in-hospital 19 0.66 (0.56-0.78) Decreased Lukito et al. [78] Preadmission 6 0.64 (0.43-0.97) Decreased Oscanoa et al. [79] Preadmission + in-hospital 22 0.56 (0.45-0.68) Decreased Poly et al. [82] Preadmission + in-hospital 16 0.66 (0.54-0.
CRediT authorship contribution statement NNN conceived of the original idea, performed meta-analyses, metaregression, sensitivity analyses, interpreted data, and wrote the first manuscript. DSH, HSN, and DKNH performed the systematic search, study selection, risk of bias assessment, and data extraction. HYC and YCC verified the analytical methods, supervised the findings of this work, and contributed to the revisions of the final manuscript. HYL and CYL provided clinical advice on the interpretation of the data and contributed to the revisions of the final manuscript. All authors approved the final manuscript as submitted and have agreed to be accountable for all aspects of the work. YCC is the guarantor of this work.
Declaration of competing interest The authors have no conflicts of interest relevant to this article to disclose. All authors declare that there are no relationships or activities that might bias, or be..
References
Agarwal, Schechter, Southern, Crandall, Tomer, Preadmission diabetesspecific risk factors for mortality in hospitalized patients with diabetes and coronavirus disease 2019, Diabetes Care Oct,
doi:10.2337/dc20-1543An, Lim, Kim, Chang, Choi et al., Machine learning prediction for mortality of patients diagnosed with COVID-19: a nationwide Korean cohort study, Sci Rep,
doi:10.1038/s41598-020-75767-2Bliden, Tantry, Usman, Abstract 12228: metformin use in patients hospitalized with COVID-19: lower inflammation, oxidative stress, and thrombotic risk markers and better clinical outcomes, Circulation,
doi:10.1161/circ.144.suppl_1.12228Bonora, Avogaro, Fadini, Disentangling conflicting evidence on DPP-4 inhibitors and outcomes of COVID-19: narrative review and meta-analysis, J Endocrinol Invest,
doi:10.1007/s40618-021-01515-6Boye, Erdemir, Zimmerman, Risk factors associated with COVID-19 hospitalization and mortality: a large claims-based analysis among people with type 2 diabetes mellitus in the United States, Diabetes Ther Aug,
doi:10.1007/s13300-021-01110-1Bramante, Ingraham, Murray, Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis, Lancet Health Longev,
doi:10.1016/s2666-7568(20)30033-7Cernigliaro, Allotta, Scondotto, Diabete e trattamento farmacologico con ipoglicemizzanti possono essere considerati fattori di rischio per gli esiti di salute in soggetti COVID-19? I risultati di uno studio nella popolazione residente in Sicilia [Can diabetes and its related hypoglycemic drug treatment be considered risk factors for health outcomes in COVID-19 patients? The results of a study in the population residing in Sicily Region (Southern Italy)], Epidemiol Prev,
doi:10.19191/ep20.5-6.S2.132Chen, Yang, Cheng, Clinical characteristics and outcomes of patients with diabetes and COVID-19 in association with glucose-lowering medication, Diabetes Care Jul,
doi:10.2337/dc20-0660Cheng, Liu, Li, Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes, Cell Metab,
doi:10.1016/j.cmet.2020.08.013Cheng, Xin, Chen, Effects of metformin, insulin on COVID-19 patients with pre-existed type 2 diabetes: A multicentral retrospective study, Life Sci Jun,
doi:10.1016/j.lfs.2021.119371Crouse, Grimes, Li, Might, Ovalle et al., Metformin use is associated with reduced mortality in a diverse population with COVID-19 and diabetes, Front Endocrinol,
doi:10.3389/fendo.2020.600439Cure, Cure, Can dapagliflozin have a protective effect against COVID-19 infection?A hypothesis, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.04.024Dave, Tamuhla, Tiffin, Risk factors for COVID-19 hospitalisation and death in people living with diabetes: a virtual cohort study from the Western Cape ProvinceSouth Africa, Diabetes Res Clin Pract,
doi:10.1016/j.diabres.2021.108925Deng, Xie, Liu, Association of diabetes with severity and mortality in hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective study, Arch Endocrinol Metab,
doi:10.20945/2359-3997000000384Do, Kim, Park, Cho, Kang, Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?, Diabetes Metab Jul,
doi:10.1016/j.diabet.2020.10.006Drucker, Coronavirus infections and Type 2 diabetes-shared pathways with therapeutic implications, Endocr Rev Jun,
doi:10.1210/endrev/bnaa011Elibol, Eren, Erdogan, Factors influencing on development of COVID-19 pneumonia and association with oral anti-diabetic drugs in hospitalized patients with diabetes mellitus, Prim Care Diabetes Oct,
doi:10.1016/j.pcd.2021.08.001Emral, Haymana, Demirci, Lower COVID-19 mortality in patients with type 2 diabetes mellitus taking dipeptidyl peptidase-4 inhibitors: results from a Turkish nationwide study, Diabetes Ther Nov,
doi:10.1007/s13300-021-01133-8Erol, Role of oxidized LDL-induced "trained macrophages" in the pathogenesis of COVID-19 and benefits of pioglitazone: a hypothesis, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.05.007Fadini, Morieri, Longato, Exposure to dipeptidyl-peptidase-4 inhibitors and COVID-19 among people with type 2 diabetes: a case-control study, Diabetes Obes Metab,
doi:10.1111/dom.14097Ghany, Palacio, Dawkins, Metformin is associated with lower hospitalizations, mortality and severe coronavirus infection among elderly medicare minority patients in 8 states in USA, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2021.02.022Giorda, Picariello, Tartaglino, From swab testing to health outcomes within the T2DM population: impact of diabetes background on COVID19 progression, Diabetes Res Clin Pract,
doi:10.1016/j.diabres.2021.109021Goodall, Reed, Ardissino, Risk factors for severe disease in patients admitted with COVID-19 to a hospital in London, England: a retrospective cohort study, Epidemiol Infect,
doi:10.1017/s0950268820002472Han, Ma, Sun, The association between anti-diabetic agents and clinical outcomes of COVID-19 in patients with diabetes: a systematic review and metaanalysis, Arch Med Res,
doi:10.1016/j.arcmed.2021.08.002Hariyanto, Intan, Hananto, Putri, Kurniawan, Pre-admission glucagonlike peptide-1 receptor agonist (GLP-1RA) and mortality from coronavirus disease 2019 (Covid-19): a systematic review, meta-analysis, and meta-regression, Diabetes Res Clin Pract,
doi:10.1016/j.diabres.2021.109031Hariyanto, Kurniawan, Dipeptidyl peptidase 4 (DPP4) inhibitor and outcome from coronavirus disease 2019 (COVID-19) in diabetic patients: a systematic review, meta-analysis, and meta-regression, J Diabetes Metab Disord,
doi:10.1007/s40200-021-00777-4Hariyanto, Kurniawan, Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection, Obes Med,
doi:10.1016/j.obmed.2020.100290Hu, Wang, The clinical characteristics and risk factors of severe COVID-19, Gerontology,
doi:10.1159/000513400Israelsen, Pottegård, Sandholdt, Madsbad, Thomsen et al., Comparable COVID-19 outcomes with current use of GLP-1 receptor agonists, DPP-4 inhibitors or SGLT-2 inhibitors among patients with diabetes who tested positive for SARS-CoV-2, Diabetes Obes Metab,
doi:10.1111/dom.14329Juan, Fang, Kwok, Perng, Chou et al., Exogenous hyperinsulinemia causes insulin resistance, hyperendothelinemia, and subsequent hypertension in rats, Metabolism Apr,
doi:10.1016/s0026-0495(99)90105-1Kahkoska, Abrahamsen, Alexander, Association between glucagonlike peptide 1 receptor agonist and sodium-glucose cotransporter 2 inhibitor use and COVID-19 outcomes, Diabetes Care Jul,
doi:10.2337/dc21-0065Kan, Zhang, Han, Mortality risk of antidiabetic agents for type 2 diabetes with COVID-19: a systematic review and meta-analysis, Front Endocrinol,
doi:10.3389/fendo.2021.708494Khunti, Knighton, Zaccardi, Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England, Lancet Diabetes Endocrinol,
doi:10.1016/s2213-8587(21)00050-4Kim, Jeon, Kim, The clinical characteristics and outcomes of patients with moderate-to-severe coronavirus disease 2019 infection and diabetes in Daegu, South Korea, Diabetes Metab J,
doi:10.4093/dmj.2020.0146Kow, Hasan, Mortality risk with preadmission metformin use in patients with COVID-19 and diabetes: a meta-analysis, J Med Virol,
doi:10.1002/jmv.26498Lally, Tsoukas, Halladay, Neill, Gravenstein et al., Metformin is associated with decreased 30-day mortality among nursing home residents infected with SARS-CoV2, J Am Med Dir Assoc Jan,
doi:10.1016/j.jamda.2020.10.031Lee, Jun, Anti-inflammatory effects of GLP-1-based therapies beyond glucose control, Mediat Inflamm,
doi:10.1155/2016/3094642Li, Wei, Li, Metformin use in diabetes prior to hospitalization: effects on mortality in Covid-19, Endocr Pract Oct,
doi:10.4158/ep-2020-0466Li, Yang, Yan, Sun, Zeng et al., Metformin in patients with COVID-19: a systematic review and meta-analysis, Front Med,
doi:10.3389/fmed.2021.704666Lim, Bae, Kwon, Nauck, COVID-19 and diabetes mellitus: from pathophysiology to clinical management, Nat Rev Endocrinol Jan,
doi:10.1038/s41574-020-00435-4Luk, Yip, Zhang, Glucose-lowering drugs and outcome from COVID-19 among patients with type 2 diabetes mellitus: a population-wide analysis in Hong Kong, BMJ Open,
doi:10.1136/bmjopen-2021-052310Lukito, Pranata, Henrina, Lim, Lawrensia et al., The effect of metformin consumption on mortality in hospitalized COVID-19 patients: a systematic review and meta-analysis, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.11.006Luo, Hu, Lu, Diabetes patients with comorbidities had unfavorable outcomes following COVID-19: a retrospective study, World J Diabetes,
doi:10.4239/wjd.v12.i10.1789Luo, Qiu, Liu, Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis, Am J Trop Med Hyg Jul,
doi:10.4269/ajtmh.20-0375Ma, Patel, Vemparala, Krishnamurthy, Metformin is associated with favorable outcomes in patients with COVID-19 and Type 2 diabetes mellitus, medRxiv,
doi:10.1101/2021.05.20.21257490Mansour, Sajjadi-Jazi, Kasaeian, Clinical characteristics and outcomes of diabetics hospitalized for COVID-19 infection: a single-centered, retrospective, observational study, EXCLI J,
doi:10.17179/excli2020-2988Meijer, Hoekstra, Van Den Oever, Treatment with a DPP-4 inhibitor at time of hospital admission for COVID-19 is not associated with improved clinical outcomes: data from the COVID-PREDICT cohort study in The Netherlands, J Diabetes Metab Disord,
doi:10.1007/s40200-021-00833-zMirani, Favacchio, Carrone, Impact of comorbidities and glycemia at admission and dipeptidyl peptidase 4 inhibitors in patients with Type 2 diabetes with COVID-19: a case series from an academic hospital in Lombardy, Italy, Diabetes Care,
doi:10.2337/dc20-1340Mirsoleymani, Nekooghadam, Marzaleh, Assessment of risk factors for severe coronavirus disease 2019 among Iranian patients, Iranian Red Crescent Medical Journal,
doi:10.32592/ircmj.2020.22.9.72Nafakhi, Alareedh, Al-Buthabhak, Shaghee, Nafakhi et al., Predictors of adverse in-hospital outcome and recovery in patients with diabetes mellitus and COVID-19 pneumonia in Iraq, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.12.014Noh, Oh, Jeong, Filion, Yu et al., Association between DPP-4 inhibitors and COVID-19-related outcomes among patients with type 2 diabetes, Diabetes Care Apr,
doi:10.2337/dc20-1824Nyland, Raja-Khan, Bettermann, Diabetes, drug treatment and mortality in COVID-19: a multinational retrospective cohort study, Diabetes,
doi:10.2337/db21-0385Oh, Song, Metformin use and risk of COVID-19 among patients with type II diabetes mellitus: an NHIS-COVID-19 database cohort study, Acta Diabetol,
doi:10.1007/s00592-020-01666-7Ong, Tan, Cañete, Lim, Robles, Association between metformin use and mortality among patients with Type 2 diabetes mellitus hospitalized for COVID-19 infection, Journal of the ASEAN Federation of Endocrine Societies,
doi:10.15605/jafes.036.02.20Orioli, Servais, Belkhir, Clinical characteristics and short-term prognosis of in-patients with diabetes and COVID-19: a retrospective study from an academic center in Belgium, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.12.020Oscanoa, Amado, Vidal, Savarino, Romero-Ortuno, Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis, Clin Diabetol,
doi:10.5603/DK.a2021.0035Pal, Banerjee, Mukherjee, Bhogal, Kaur et al., Dipeptidyl peptidase-4 inhibitor use and mortality in COVID-19 patients with diabetes mellitus: an updated systematic review and meta-analysis, Ther Adv Endocrinol Metab,
doi:10.1177/2042018821996482Patoulias, Doumas, Dipeptidyl Peptidase-4 inhibitors and COVID-19-related deaths among patients with type 2 diabetes mellitus: a meta-analysis of observational studies, Endocrinol Metab,
doi:10.3803/EnM.2021.1048Pazoki, Chichagi, Hadadi, Association of clinical characteristics, antidiabetic and cardiovascular agents with diabetes mellitus and COVID-19: a 7month follow-up cohort study, J Diabetes Metab Disord,
doi:10.1007/s40200-021-00901-4Philipose, Smati, Wong, Aspey, Mendall, Obesity, old age, and frailty are the true risk factors for COVID-19 mortality and not chronic disease or ethnicity, medRxiv,
doi:10.1101/2020.08.12.20156257Poly, Islam, Li, Lin, Hsu et al., Metformin use is associated with decreased mortality in COVID-19 patients with diabetes: evidence from retrospective studies and biological mechanism, J Clin Med Aug,
doi:10.3390/jcm10163507Pérez-Belmonte, Torres-Peña, Md, Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study, BMC Med Nov,
doi:10.1186/s12916-020-01832-2Rakhmat, Kusmala, Handayani, Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus disease 2019 (COVID-19) -a systematic review, meta-analysis, and meta-regression, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2021.03.027Ramos-Rincón, Pérez-Belmonte, Carrasco-Sánchez, Cardiometabolic therapy and mortality in very old patients with diabetes hospitalized due to COVID-19, J Gerontol A Biol Sci Med Sci,
doi:10.1093/gerona/glab124Satman, Demirci, Haymana, Unexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbul, Diabetes Res Clin Pract,
doi:10.1016/j.diabres.2021.108753Saygili, Karakiliç, Mert, Mirci, Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period, Ir J Med Sci Oct,
doi:10.1007/s11845-021-02823-9Schlesinger, Neuenschwander, Lang, Risk phenotypes of diabetes and association with COVID-19 severity and death: a living systematic review and meta-analysis, Diabetologia Jul,
doi:10.1007/s00125-021-05458-8Shestakova, Vikulova, Isakov, Dedov, Diabetes and COVID-19: analysis of the clinical outcomes according to the data of the Russian diabetes registry, Probl Endokrinol (Mosk),
doi:10.14341/probl12458Silverii, Monami, Cernigliaro, Are diabetes and its medications risk factors for the development of COVID-19? Data from a population-based study in Sicily, Nutr Metab Cardiovasc Dis,
doi:10.1016/j.numecd.2020.09.028Sourij, Aziz, Bräuer, COVID-19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission, Diabetes Obes Metab,
doi:10.1111/dom.14256Sterne, Gavaghan, Egger, Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature, J Clin Epidemiol,
doi:10.1016/s0895-4356(00)00242-0Strollo, Maddaloni, Dauriz, Pedone, Buzzetti et al., Use of DPP4 inhibitors in Italy does not correlate with diabetes prevalence among COVID-19 deaths, Diabetes Res Clin Pract Jan,
doi:10.1016/j.diabres.2020.108444Sun, Cheng, Kim, Ahmed, Manem, Is metformin use associated with a decreased mortality for COVID-19 diabetic patients? A meta-analysis, Journal of the Endocrine Society,
doi:10.1210/jendso/bvab048.709Tamura, Said, De Freitas, Rubio, Outcome and death risk of diabetes patients with Covid-19 receiving pre-hospital and in-hospital metformin therapies, Diabetol Metab Syndr,
doi:10.1186/s13098-021-00695-8Tripathy, Daniele, Fiorentino, Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study, Diabetologia Oct,
doi:10.1007/s00125-013-2976-zVankadari, Wilce, Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26, Emerg Microbes Infect,
doi:10.1080/22221751.2020.1739565Varghese, Samuel, Liskova, Kubatka, Büsselberg, Diabetes and coronavirus (SARS-CoV-2): molecular mechanism of metformin intervention and the scientific basis of drug repurposing, PLoS Pathog Jun,
doi:10.1371/journal.ppat.1009634Wander, Lowy, Beste, Prior glucose-lowering medication use and 30day outcomes among 64,892 veterans with diabetesand COVID-19, Diabetes Care,
doi:10.2337/dc21-1351Wang, Cooper, Gokhale, Association of Metformin with susceptibility to COVID-19 in people with type 2 diabetes, J Clin Endocrinol Metab,
doi:10.1210/clinem/dgab067Wang, Van Oekelen, Mouhieddine, A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward, J Hematol Oncol,
doi:10.1186/s13045-020-00934-xWargny, Potier, Gourdy, Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study, Diabetologia Apr,
doi:10.1007/s00125-020-05351-wWells, Shea, Connell, The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
Wg, The combination of estimates from different experiments, Biometrics
Who N.D, Coronavirus disease (COVID-19) pandemic
Wong, Lui, Lui, Use of DPP4i reduced odds of clinical deterioration and hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: propensity score analysis of a territory-wide cohort in Hong Kong, Diabetes & Metabolism,
doi:10.1016/j.diabet.2021.101307Yan, Yang, Wang, Clinical characteristics and outcomes of patients with severe covid-19 with diabetes, BMJ Open Diabetes Res Care Apr,
doi:10.1136/bmjdrc-2020-001343Yang, Cai, Zhang, Insulin treatment may increase adverse outcomes in patients with COVID-19 and diabetes: a systematic review and meta-analysis, Front Endocrinol,
doi:10.3389/fendo.2021.696087Yang, Sun, Zhang, Zhang, The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus, Diabetes Res Clin Pract,
doi:10.1016/j.diabres.2021.108977Yuan, Li, Chen, Wang, Wang, Association of glycosylated haemoglobin HbA1c levels with outcome in patients with COVID-19: a retrospective study, J Cell Mol Med Apr,
doi:10.1111/jcmm.16431Zhou, Myers, Li, Role of AMP-activated protein kinase in mechanism of metformin action, J Clin Invest Oct,
doi:10.1172/jci13505{ 'indexed': {'date-parts': [[2024, 5, 11]], 'date-time': '2024-05-11T09:11:15Z', 'timestamp': 1715418675457},
'reference-count': 98,
'publisher': 'Elsevier BV',
'license': [ { 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'},
{ 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'stm-asf',
'delay-in-days': 0,
'URL': 'https://doi.org/10.15223/policy-017'},
{ 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'stm-asf',
'delay-in-days': 0,
'URL': 'https://doi.org/10.15223/policy-037'},
{ 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'stm-asf',
'delay-in-days': 0,
'URL': 'https://doi.org/10.15223/policy-012'},
{ 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'stm-asf',
'delay-in-days': 0,
'URL': 'https://doi.org/10.15223/policy-029'},
{ 'start': { 'date-parts': [[2022, 6, 1]],
'date-time': '2022-06-01T00:00:00Z',
'timestamp': 1654041600000},
'content-version': 'stm-asf',
'delay-in-days': 0,
'URL': 'https://doi.org/10.15223/policy-004'}],
'content-domain': { 'domain': [ 'metabolismjournal.com', 'clinicalkey.fr', 'clinicalkey.jp',
'clinicalkey.com.au', 'clinicalkey.es', 'clinicalkey.com', 'elsevier.com',
'sciencedirect.com'],
'crossmark-restriction': True},
'published-print': {'date-parts': [[2022, 6]]},
'DOI': '10.1016/j.metabol.2022.155196',
'type': 'journal-article',
'created': {'date-parts': [[2022, 4, 1]], 'date-time': '2022-04-01T01:02:19Z', 'timestamp': 1648774939000},
'page': '155196',
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 47,
'title': 'Preadmission use of antidiabetic medications and mortality among patients with COVID-19 having '
'type 2 diabetes: A meta-analysis',
'prefix': '10.1016',
'volume': '131',
'author': [ {'given': 'Nam Nhat', 'family': 'Nguyen', 'sequence': 'first', 'affiliation': []},
{'given': 'Dung Si', 'family': 'Ho', 'sequence': 'additional', 'affiliation': []},
{'given': 'Hung Song', 'family': 'Nguyen', 'sequence': 'additional', 'affiliation': []},
{'given': 'Dang Khanh Ngan', 'family': 'Ho', 'sequence': 'additional', 'affiliation': []},
{'given': 'Hung-Yuan', 'family': 'Li', 'sequence': 'additional', 'affiliation': []},
{'given': 'Chia-Yuan', 'family': 'Lin', 'sequence': 'additional', 'affiliation': []},
{'given': 'Hsiao-Yean', 'family': 'Chiu', 'sequence': 'additional', 'affiliation': []},
{'given': 'Yang-Ching', 'family': 'Chen', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'reference': [ { 'key': '10.1016/j.metabol.2022.155196_bb0005',
'unstructured': 'WHO n.d. Coronavirus disease (COVID-19) pandemic. Updated November 23. '
'Accessed November 30, 2021. '
'https://www.who.int/emergencies/diseases/novel-coronavirus-2019.'},
{ 'issue': '3',
'key': '10.1016/j.metabol.2022.155196_bb0010',
'doi-asserted-by': 'crossref',
'first-page': '255',
'DOI': '10.1159/000513400',
'article-title': 'The clinical characteristics and risk factors of severe COVID-19',
'volume': '67',
'author': 'Hu',
'year': '2021',
'journal-title': 'Gerontology'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0015',
'doi-asserted-by': 'crossref',
'first-page': '11',
'DOI': '10.1038/s41574-020-00435-4',
'article-title': 'COVID-19 and diabetes mellitus: from pathophysiology to clinical '
'management',
'volume': '17',
'author': 'Lim',
'year': '2021',
'journal-title': 'Nat Rev Endocrinol'},
{ 'issue': '5',
'key': '10.1016/j.metabol.2022.155196_bb0020',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0251916',
'article-title': 'DPP-4 inhibitors may improve the mortality of coronavirus disease 2019: '
'a meta-analysis',
'volume': '16',
'author': 'Yang',
'year': '2021',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0025',
'article-title': 'The association between anti-diabetic agents and clinical outcomes of '
'COVID-19 in patients with diabetes: a systematic review and '
'meta-analysis',
'author': 'Han',
'year': '2021',
'journal-title': 'Arch Med Res'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0030',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1007/s40200-021-00777-4',
'article-title': 'Dipeptidyl peptidase 4 (DPP4) inhibitor and outcome from coronavirus '
'disease 2019 (COVID-19) in diabetic patients: a systematic review, '
'meta-analysis, and meta-regression',
'volume': '20',
'author': 'Hariyanto',
'year': '2021',
'journal-title': 'J Diabetes Metab Disord'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0035',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2021.109031',
'article-title': 'Pre-admission glucagon-like peptide-1 receptor agonist (GLP-1RA) and '
'mortality from coronavirus disease 2019 (Covid-19): a systematic '
'review, meta-analysis, and meta-regression',
'volume': '179',
'author': 'Hariyanto',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{'key': '10.1016/j.metabol.2022.155196_bb0040', 'author': 'Wells'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0045',
'doi-asserted-by': 'crossref',
'first-page': '101',
'DOI': '10.2307/3001666',
'article-title': 'The combination of estimates from different experiments',
'volume': '10',
'author': 'Wg',
'year': '1954',
'journal-title': 'Biometrics'},
{ 'issue': '11',
'key': '10.1016/j.metabol.2022.155196_bb0050',
'doi-asserted-by': 'crossref',
'first-page': '1539',
'DOI': '10.1002/sim.1186',
'article-title': 'Quantifying heterogeneity in a meta-analysis',
'volume': '21',
'author': 'Higgins',
'year': '2002',
'journal-title': 'Stat Med'},
{ 'issue': '11',
'key': '10.1016/j.metabol.2022.155196_bb0055',
'doi-asserted-by': 'crossref',
'first-page': '1119',
'DOI': '10.1016/S0895-4356(00)00242-0',
'article-title': 'Publication and related bias in meta-analysis: power of statistical '
'tests and prevalence in the literature',
'volume': '53',
'author': 'Sterne',
'year': '2000',
'journal-title': 'J Clin Epidemiol'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0060',
'doi-asserted-by': 'crossref',
'first-page': '537',
'DOI': '10.1016/j.cmet.2020.08.013',
'article-title': 'Metformin is associated with higher incidence of acidosis, but not '
'mortality, in individuals with COVID-19 and pre-existing type 2 '
'diabetes',
'volume': '32',
'author': 'Cheng',
'year': '2020',
'journal-title': 'Cell Metab'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0065',
'first-page': '1',
'article-title': 'Association of clinical characteristics, antidiabetic and '
'cardiovascular agents with diabetes mellitus and COVID-19: a 7-month '
'follow-up cohort study',
'author': 'Pazoki',
'year': '2021',
'journal-title': 'J Diabetes Metab Disord'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0070',
'doi-asserted-by': 'crossref',
'first-page': '2339',
'DOI': '10.2337/dc20-1543',
'article-title': 'Preadmission diabetes-specific risk factors for mortality in '
'hospitalized patients with diabetes and coronavirus disease 2019',
'volume': '43',
'author': 'Agarwal',
'year': '2020',
'journal-title': 'Diabetes Care'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0075',
'doi-asserted-by': 'crossref',
'DOI': '10.1038/s41598-020-75767-2',
'article-title': 'Machine learning prediction for mortality of patients diagnosed with '
'COVID-19: a nationwide Korean cohort study',
'volume': '10',
'author': 'An',
'year': '2020',
'journal-title': 'Sci Rep'},
{ 'issue': 'Suppl_1',
'key': '10.1016/j.metabol.2022.155196_bb0080',
'doi-asserted-by': 'crossref',
'DOI': '10.1161/circ.144.suppl_1.12228',
'article-title': 'Abstract 12228: metformin use in patients hospitalized with COVID-19: '
'lower inflammation, oxidative stress, and thrombotic risk markers and '
'better clinical outcomes',
'volume': '144',
'author': 'Bliden',
'year': '2021',
'journal-title': 'Circulation'},
{ 'issue': '8',
'key': '10.1016/j.metabol.2022.155196_bb0085',
'doi-asserted-by': 'crossref',
'first-page': '2223',
'DOI': '10.1007/s13300-021-01110-1',
'article-title': 'Risk factors associated with COVID-19 hospitalization and mortality: a '
'large claims-based analysis among people with type 2 diabetes mellitus '
'in the United States',
'volume': '12',
'author': 'Boye',
'year': '2021',
'journal-title': 'Diabetes Ther'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0090',
'doi-asserted-by': 'crossref',
'first-page': 'e34',
'DOI': '10.1016/S2666-7568(20)30033-7',
'article-title': 'Metformin and risk of mortality in patients hospitalised with COVID-19: '
'a retrospective cohort analysis',
'volume': '2',
'author': 'Bramante',
'year': '2021',
'journal-title': 'Lancet Health Longev.'},
{ 'issue': '5-6 Suppl 2',
'key': '10.1016/j.metabol.2022.155196_bb0095',
'first-page': '315',
'article-title': 'Diabete e trattamento farmacologico con ipoglicemizzanti possono essere '
'considerati fattori di rischio per gli esiti di salute in soggetti '
'COVID-19? I risultati di uno studio nella popolazione residente in '
'Sicilia',
'volume': '44',
'author': 'Cernigliaro',
'year': '2020',
'journal-title': 'Epidemiol Prev'},
{ 'issue': '7',
'key': '10.1016/j.metabol.2022.155196_bb0100',
'doi-asserted-by': 'crossref',
'first-page': '1399',
'DOI': '10.2337/dc20-0660',
'article-title': 'Clinical characteristics and outcomes of patients with diabetes and '
'COVID-19 in association with glucose-lowering medication',
'volume': '43',
'author': 'Chen',
'year': '2020',
'journal-title': 'Diabetes Care'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0105',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.lfs.2021.119371',
'article-title': 'Effects of metformin, insulin on COVID-19 patients with pre-existed '
'type 2 diabetes: A multicentral retrospective study',
'volume': '275',
'author': 'Cheng',
'year': '2021',
'journal-title': 'Life Sci'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0110',
'article-title': 'Metformin use is associated with reduced mortality in a diverse '
'population with COVID-19 and diabetes',
'volume': '11',
'author': 'Crouse',
'year': '2020',
'journal-title': 'Front Endocrinol (Lausanne)'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0115',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2021.108925',
'article-title': 'Risk factors for COVID-19 hospitalisation and death in people living '
'with diabetes: a virtual cohort study from the Western Cape '
'ProvinceSouth Africa',
'volume': '177',
'author': 'Dave',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'issue': '5',
'key': '10.1016/j.metabol.2022.155196_bb0120',
'first-page': '596',
'article-title': 'Association of diabetes with severity and mortality in hospitalized '
'patients with COVID-19 in Wuhan, China: a single-centered, '
'retrospective study',
'volume': '65',
'author': 'Deng',
'year': '2021',
'journal-title': 'Arch Endocrinol Metab'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0125',
'article-title': 'Is there an association between metformin use and clinical outcomes in '
'diabetes patients with COVID-19?',
'volume': '47',
'author': 'Do JY',
'year': '2021',
'journal-title': 'Diabetes Metab'},
{ 'issue': '5',
'key': '10.1016/j.metabol.2022.155196_bb0130',
'doi-asserted-by': 'crossref',
'first-page': '806',
'DOI': '10.1016/j.pcd.2021.08.001',
'article-title': 'Factors influencing on development of COVID-19 pneumonia and '
'association with oral anti-diabetic drugs in hospitalized patients with '
'diabetes mellitus',
'volume': '15',
'author': 'Elibol',
'year': '2021',
'journal-title': 'Prim Care Diabetes'},
{ 'issue': '11',
'key': '10.1016/j.metabol.2022.155196_bb0135',
'doi-asserted-by': 'crossref',
'first-page': '2857',
'DOI': '10.1007/s13300-021-01133-8',
'article-title': 'Lower COVID-19 mortality in patients with type 2 diabetes mellitus '
'taking dipeptidyl peptidase-4 inhibitors: results from a Turkish '
'nationwide study',
'volume': '12',
'author': 'Emral',
'year': '2021',
'journal-title': 'Diabetes Ther'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0140',
'doi-asserted-by': 'crossref',
'first-page': '1946',
'DOI': '10.1111/dom.14097',
'article-title': 'Exposure to dipeptidyl-peptidase-4 inhibitors and COVID-19 among people '
'with type 2 diabetes: a case-control study',
'volume': '22',
'author': 'Fadini',
'year': '2020',
'journal-title': 'Diabetes Obes Metab.'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0145',
'doi-asserted-by': 'crossref',
'first-page': '513',
'DOI': '10.1016/j.dsx.2021.02.022',
'article-title': 'Metformin is associated with lower hospitalizations, mortality and '
'severe coronavirus infection among elderly medicare minority patients '
'in 8 states in USA',
'volume': '15',
'author': 'Ghany',
'year': '2021',
'journal-title': 'Diabetes Metab Syndr'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0150',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2021.109021',
'article-title': 'From swab testing to health outcomes within the T2DM population: impact '
'of diabetes background on COVID19 progression',
'volume': '180',
'author': 'Giorda',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0155',
'doi-asserted-by': 'crossref',
'DOI': '10.1017/S0950268820002472',
'article-title': 'Risk factors for severe disease in patients admitted with COVID-19 to a '
'hospital in London, England: a retrospective cohort study.',
'volume': '148',
'author': 'Goodall',
'year': '2020',
'journal-title': 'Epidemiol Infect'},
{ 'issue': '6',
'key': '10.1016/j.metabol.2022.155196_bb0160',
'doi-asserted-by': 'crossref',
'first-page': '1397',
'DOI': '10.1111/dom.14329',
'article-title': 'Comparable COVID-19 outcomes with current use of GLP-1 receptor '
'agonists, DPP-4 inhibitors or SGLT-2 inhibitors among patients with '
'diabetes who tested positive for SARS-CoV-2',
'volume': '23',
'author': 'Israelsen',
'year': '2021',
'journal-title': 'Diabetes Obes Metab'},
{ 'issue': '7',
'key': '10.1016/j.metabol.2022.155196_bb0165',
'doi-asserted-by': 'crossref',
'first-page': '1564',
'DOI': '10.2337/dc21-0065',
'article-title': 'Association between glucagon-like peptide 1 receptor agonist and '
'sodium-glucose cotransporter 2 inhibitor use and COVID-19 outcomes',
'volume': '44',
'author': 'Kahkoska',
'year': '2021',
'journal-title': 'Diabetes Care'},
{ 'issue': '5',
'key': '10.1016/j.metabol.2022.155196_bb0170',
'doi-asserted-by': 'crossref',
'first-page': '293',
'DOI': '10.1016/S2213-8587(21)00050-4',
'article-title': 'Prescription of glucose-lowering therapies and risk of COVID-19 '
'mortality in people with type 2 diabetes: a nationwide observational '
'study in England',
'volume': '9',
'author': 'Khunti',
'year': '2021',
'journal-title': 'Lancet Diabetes Endocrinol'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0175',
'doi-asserted-by': 'crossref',
'first-page': '602',
'DOI': '10.4093/dmj.2020.0146',
'article-title': 'The clinical characteristics and outcomes of patients with '
'moderate-to-severe coronavirus disease 2019 infection and diabetes in '
'Daegu, South Korea',
'volume': '44',
'author': 'Kim',
'year': '2020',
'journal-title': 'Diabetes Metab J'},
{ 'issue': '8',
'key': '10.1016/j.metabol.2022.155196_bb0180',
'doi-asserted-by': 'crossref',
'first-page': '842',
'DOI': '10.1016/j.eprac.2021.05.011',
'article-title': 'Predictors of severe COVID-19 in patients with diabetes: a multicenter '
'review',
'volume': '27',
'author': 'Kristan',
'year': '2021',
'journal-title': 'Endocr Pract'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0185',
'doi-asserted-by': 'crossref',
'first-page': '193',
'DOI': '10.1016/j.jamda.2020.10.031',
'article-title': 'Metformin is associated with decreased 30-day mortality among nursing '
'home residents infected with SARS-CoV2',
'volume': '22',
'author': 'Lally',
'year': '2021',
'journal-title': 'J Am Med Dir Assoc'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0190',
'article-title': 'Effects of diabetes and blood glucose on COVID-19 mortality: a '
'retrospective observational study',
'author': 'Li',
'year': '2021',
'journal-title': 'medRxiv'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0195',
'doi-asserted-by': 'crossref',
'first-page': '1166',
'DOI': '10.4158/EP-2020-0466',
'article-title': 'Metformin use in diabetes prior to hospitalization: effects on '
'mortality in Covid-19',
'volume': '26',
'author': 'Li',
'year': '2020',
'journal-title': 'Endocr Pract'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0200',
'article-title': 'Glucose-lowering drugs and outcome from COVID-19 among patients with '
'type 2 diabetes mellitus: a population-wide analysis in Hong Kong',
'volume': '11',
'author': 'AOY',
'year': '2021',
'journal-title': 'BMJ Open'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0205',
'doi-asserted-by': 'crossref',
'first-page': '69',
'DOI': '10.4269/ajtmh.20-0375',
'article-title': 'Metformin treatment was associated with decreased mortality in COVID-19 '
'patients with diabetes in a retrospective analysis',
'volume': '103',
'author': 'Luo',
'year': '2020',
'journal-title': 'Am J Trop Med Hyg'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0210',
'doi-asserted-by': 'crossref',
'first-page': '1789',
'DOI': '10.4239/wjd.v12.i10.1789',
'article-title': 'Diabetes patients with comorbidities had unfavorable outcomes following '
'COVID-19: a retrospective study',
'volume': '12',
'author': 'Luo',
'year': '2021',
'journal-title': 'World J Diabetes'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0215',
'article-title': 'Metformin is associated with favorable outcomes in patients with '
'COVID-19 and Type 2 diabetes mellitus',
'author': 'Ma',
'year': '2021',
'journal-title': 'medRxiv'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0220',
'first-page': '1533',
'article-title': 'Clinical characteristics and outcomes of diabetics hospitalized for '
'COVID-19 infection: a single-centered, retrospective, observational '
'study',
'volume': '19',
'author': 'Mansour',
'year': '2020',
'journal-title': 'EXCLI J'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0225',
'first-page': '1',
'article-title': 'Treatment with a DPP-4 inhibitor at time of hospital admission for '
'COVID-19 is not associated with improved clinical outcomes: data from '
'the COVID-PREDICT cohort study in The Netherlands',
'author': 'Meijer',
'year': '2021',
'journal-title': 'J Diabetes Metab Disord'},
{ 'issue': '12',
'key': '10.1016/j.metabol.2022.155196_bb0230',
'doi-asserted-by': 'crossref',
'first-page': '3042',
'DOI': '10.2337/dc20-1340',
'article-title': 'Impact of comorbidities and glycemia at admission and dipeptidyl '
'peptidase 4 inhibitors in patients with Type 2 diabetes with COVID-19: '
'a case series from an academic hospital in Lombardy, Italy',
'volume': '43',
'author': 'Mirani',
'year': '2020',
'journal-title': 'Diabetes Care.'},
{ 'issue': '9',
'key': '10.1016/j.metabol.2022.155196_bb0235',
'article-title': 'Assessment of risk factors for severe coronavirus disease 2019 among '
'Iranian patients',
'volume': '22',
'author': 'Mirsoleymani',
'year': '2020',
'journal-title': 'Iranian Red Crescent Medical Journal'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0240',
'doi-asserted-by': 'crossref',
'first-page': '33',
'DOI': '10.1016/j.dsx.2020.12.014',
'article-title': 'Predictors of adverse in-hospital outcome and recovery in patients with '
'diabetes mellitus and COVID-19 pneumonia in Iraq',
'volume': '15',
'author': 'Nafakhi',
'year': '2021',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0245',
'doi-asserted-by': 'crossref',
'first-page': 'e64',
'DOI': '10.2337/dc20-1824',
'article-title': 'Association between DPP-4 inhibitors and COVID-19-related outcomes '
'among patients with type 2 diabetes',
'volume': '44',
'author': 'Noh',
'year': '2021',
'journal-title': 'Diabetes Care'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0250',
'doi-asserted-by': 'crossref',
'DOI': '10.2337/db21-0385',
'article-title': 'Diabetes, drug treatment and mortality in COVID-19: a multinational '
'retrospective cohort study',
'author': 'Nyland',
'year': '2021',
'journal-title': 'Diabetes'},
{ 'issue': '6',
'key': '10.1016/j.metabol.2022.155196_bb0255',
'doi-asserted-by': 'crossref',
'first-page': '771',
'DOI': '10.1007/s00592-020-01666-7',
'article-title': 'Metformin use and risk of COVID-19 among patients with type II diabetes '
'mellitus: an NHIS-COVID-19 database cohort study',
'volume': '58',
'author': 'Oh',
'year': '2021',
'journal-title': 'Acta Diabetol'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0260',
'doi-asserted-by': 'crossref',
'first-page': '133',
'DOI': '10.15605/jafes.036.02.20',
'article-title': 'Association between metformin use and mortality among patients with '
'Type 2 diabetes mellitus hospitalized for COVID-19 infection',
'volume': '36',
'author': 'Ong',
'year': '2021',
'journal-title': 'Journal of the ASEAN Federation of Endocrine Societies'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0265',
'doi-asserted-by': 'crossref',
'first-page': '149',
'DOI': '10.1016/j.dsx.2020.12.020',
'article-title': 'Clinical characteristics and short-term prognosis of in-patients with '
'diabetes and COVID-19: a retrospective study from an academic center in '
'Belgium',
'volume': '15',
'author': 'Orioli',
'year': '2021',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0270',
'doi-asserted-by': 'crossref',
'first-page': '359',
'DOI': '10.1186/s12916-020-01832-2',
'article-title': 'Mortality and other adverse outcomes in patients with type 2 diabetes '
'mellitus admitted for COVID-19 in association with glucose-lowering '
'drugs: a nationwide cohort study',
'volume': '18',
'author': 'Pérez-Belmonte',
'year': '2020',
'journal-title': 'BMC Med'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0275',
'article-title': 'Obesity, old age, and frailty are the true risk factors for COVID-19 '
'mortality and not chronic disease or ethnicity',
'author': 'Philipose',
'year': '2020',
'journal-title': 'medRxiv'},
{ 'issue': '8',
'key': '10.1016/j.metabol.2022.155196_bb0280',
'doi-asserted-by': 'crossref',
'first-page': 'e102',
'DOI': '10.1093/gerona/glab124',
'article-title': 'Cardiometabolic therapy and mortality in very old patients with '
'diabetes hospitalized due to COVID-19',
'volume': '76',
'author': 'Ramos-Rincón',
'year': '2021',
'journal-title': 'J Gerontol A Biol Sci Med Sci'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0285',
'article-title': 'Retrospective assessment of treatments of hospitalized Covid-19 '
'patients',
'author': 'Ravindra',
'year': '2021',
'journal-title': 'medRxiv'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0290',
'doi-asserted-by': 'crossref',
'first-page': '45',
'DOI': '10.1080/07435800.2020.1856865',
'article-title': 'Insulin use, diabetes control, and outcomes in patients with COVID-19',
'volume': '46',
'author': 'Riahi',
'year': '2021',
'journal-title': 'Endocr Res'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0295',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2021.108753',
'article-title': 'Unexpectedly lower mortality rates in COVID-19 patients with and '
'without type 2 diabetes in Istanbul',
'volume': '174',
'author': 'Satman',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0300',
'first-page': '1',
'article-title': 'Preadmission usage of metformin and mortality in COVID-19 patients '
'including the post-discharge period',
'author': 'Saygili',
'year': '2021',
'journal-title': 'Ir J Med Sci'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0305',
'doi-asserted-by': 'crossref',
'first-page': '35',
'DOI': '10.14341/probl12458',
'article-title': 'Diabetes and COVID-19: analysis of the clinical outcomes according to '
'the data of the Russian diabetes registry',
'volume': '66',
'author': 'Shestakova',
'year': '2020',
'journal-title': 'Probl Endokrinol (Mosk)'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0310',
'doi-asserted-by': 'crossref',
'first-page': '396',
'DOI': '10.1016/j.numecd.2020.09.028',
'article-title': 'Are diabetes and its medications risk factors for the development of '
'COVID-19? Data from a population-based study in Sicily',
'volume': '31',
'author': 'Silverii',
'year': '2021',
'journal-title': 'Nutr Metab Cardiovasc Dis'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0315',
'doi-asserted-by': 'crossref',
'first-page': '589',
'DOI': '10.1111/dom.14256',
'article-title': 'COVID-19 fatality prediction in people with diabetes and prediabetes '
'using a simple score upon hospital admission',
'volume': '23',
'author': 'Sourij',
'year': '2021',
'journal-title': 'Diabetes Obes Metab.'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0320',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2020.108444',
'article-title': 'Use of DPP4 inhibitors in Italy does not correlate with diabetes '
'prevalence among COVID-19 deaths',
'volume': '171',
'author': 'Strollo',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0325',
'doi-asserted-by': 'crossref',
'first-page': '76',
'DOI': '10.1186/s13098-021-00695-8',
'article-title': 'Outcome and death risk of diabetes patients with Covid-19 receiving '
'pre-hospital and in-hospital metformin therapies',
'volume': '13',
'author': 'Tamura',
'year': '2021',
'journal-title': 'Diabetol Metab Syndr'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0330',
'doi-asserted-by': 'crossref',
'DOI': '10.2337/dc21-1351',
'article-title': 'Prior glucose-lowering medication use and 30-day outcomes among 64,892 '
'veterans with diabetesand COVID-19',
'author': 'Wander',
'year': '2021',
'journal-title': 'Diabetes Care'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0335',
'doi-asserted-by': 'crossref',
'first-page': '94',
'DOI': '10.1186/s13045-020-00934-x',
'article-title': 'A tertiary center experience of multiple myeloma patients with '
'COVID-19: lessons learned and the path forward',
'volume': '13',
'author': 'Wang',
'year': '2020',
'journal-title': 'J Hematol Oncol'},
{ 'issue': '5',
'key': '10.1016/j.metabol.2022.155196_bb0340',
'doi-asserted-by': 'crossref',
'first-page': '1255',
'DOI': '10.1210/clinem/dgab067',
'article-title': 'Association of Metformin with susceptibility to COVID-19 in people with '
'type 2 diabetes',
'volume': '106',
'author': 'Wang',
'year': '2021',
'journal-title': 'J Clin Endocrinol Metab'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0345',
'doi-asserted-by': 'crossref',
'first-page': '778',
'DOI': '10.1007/s00125-020-05351-w',
'article-title': 'Predictors of hospital discharge and mortality in patients with '
'diabetes and COVID-19: updated results from the nationwide CORONADO '
'study',
'volume': '64',
'author': 'Wargny',
'year': '2021',
'journal-title': 'Diabetologia'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0350',
'article-title': 'Use of DPP4i reduced odds of clinical deterioration and '
'hyperinflammatory syndrome in COVID-19 patients with type 2 diabetes: '
'propensity score analysis of a territory-wide cohort in Hong Kong',
'author': 'CKH',
'year': '2021',
'journal-title': 'Diabetes & Metabolism'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0355',
'doi-asserted-by': 'crossref',
'DOI': '10.1136/bmjdrc-2020-001343',
'article-title': 'Clinical characteristics and outcomes of patients with severe covid-19 '
'with diabetes',
'volume': '8',
'author': 'Yan',
'year': '2020',
'journal-title': 'BMJ Open Diabetes Res Care'},
{ 'issue': '7',
'key': '10.1016/j.metabol.2022.155196_bb0360',
'doi-asserted-by': 'crossref',
'first-page': '3484',
'DOI': '10.1111/jcmm.16431',
'article-title': 'Association of glycosylated haemoglobin HbA1c levels with outcome in '
'patients with COVID-19: a retrospective study',
'volume': '25',
'author': 'Yuan',
'year': '2021',
'journal-title': 'J Cell Mol Med'},
{ 'issue': '7',
'key': '10.1016/j.metabol.2022.155196_bb0365',
'doi-asserted-by': 'crossref',
'first-page': '1379',
'DOI': '10.1007/s40618-021-01515-6',
'article-title': 'Disentangling conflicting evidence on DPP-4 inhibitors and outcomes of '
'COVID-19: narrative review and meta-analysis',
'volume': '44',
'author': 'Bonora',
'year': '2021',
'journal-title': 'J Endocrinol Invest'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0370',
'article-title': 'Metformin use is associated with reduced mortality rate from '
'coronavirus disease 2019 (COVID-19) infection',
'volume': '19',
'author': 'Hariyanto',
'year': '2020',
'journal-title': 'Obes Med'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0375',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fendo.2021.708494',
'article-title': 'Mortality risk of antidiabetic agents for type 2 diabetes with '
'COVID-19: a systematic review and meta-analysis',
'volume': '12',
'author': 'Kan',
'year': '2021',
'journal-title': 'Front Endocrinol (Lausanne)'},
{ 'issue': '2',
'key': '10.1016/j.metabol.2022.155196_bb0380',
'doi-asserted-by': 'crossref',
'first-page': '695',
'DOI': '10.1002/jmv.26498',
'article-title': 'Mortality risk with preadmission metformin use in patients with '
'COVID-19 and diabetes: a meta-analysis',
'volume': '93',
'author': 'Kow',
'year': '2021',
'journal-title': 'J Med Virol'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0385',
'article-title': 'Metformin in patients with COVID-19: a systematic review and '
'meta-analysis',
'volume': '8',
'author': 'Li',
'year': '2021',
'journal-title': 'Front Med (Lausanne)'},
{ 'issue': '6',
'key': '10.1016/j.metabol.2022.155196_bb0390',
'doi-asserted-by': 'crossref',
'first-page': '2177',
'DOI': '10.1016/j.dsx.2020.11.006',
'article-title': 'The effect of metformin consumption on mortality in hospitalized '
'COVID-19 patients: a systematic review and meta-analysis',
'volume': '14',
'author': 'Lukito',
'year': '2020',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0395',
'first-page': '317',
'article-title': 'Metformin therapy and severity and mortality of SARS-CoV-2 infection: a '
'meta-analysis',
'volume': '10',
'author': 'Oscanoa',
'year': '2021',
'journal-title': 'Clin Diabetol'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0400',
'doi-asserted-by': 'crossref',
'DOI': '10.1177/2042018821996482',
'article-title': 'Dipeptidyl peptidase-4 inhibitor use and mortality in COVID-19 patients '
'with diabetes mellitus: an updated systematic review and meta-analysis',
'volume': '12',
'author': 'Pal',
'year': '2021',
'journal-title': 'Ther Adv Endocrinol Metab'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0405',
'doi-asserted-by': 'crossref',
'first-page': '904',
'DOI': '10.3803/EnM.2021.1048',
'article-title': 'Dipeptidyl Peptidase-4 inhibitors and COVID-19-related deaths among '
'patients with type 2 diabetes mellitus: a meta-analysis of '
'observational studies',
'volume': '36',
'author': 'Patoulias',
'year': '2021',
'journal-title': 'Endocrinol Metab (Seoul)'},
{ 'issue': '16',
'key': '10.1016/j.metabol.2022.155196_bb0410',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/jcm10163507',
'article-title': 'Metformin use is associated with decreased mortality in COVID-19 '
'patients with diabetes: evidence from retrospective studies and '
'biological mechanism',
'volume': '10',
'author': 'Poly',
'year': '2021',
'journal-title': 'J Clin Med'},
{ 'issue': '3',
'key': '10.1016/j.metabol.2022.155196_bb0415',
'doi-asserted-by': 'crossref',
'first-page': '777',
'DOI': '10.1016/j.dsx.2021.03.027',
'article-title': 'Dipeptidyl peptidase-4 (DPP-4) inhibitor and mortality in coronavirus '
'disease 2019 (COVID-19) - a systematic review, meta-analysis, and '
'meta-regression',
'volume': '15',
'author': 'Rakhmat',
'year': '2021',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '6',
'key': '10.1016/j.metabol.2022.155196_bb0420',
'doi-asserted-by': 'crossref',
'first-page': '423',
'DOI': '10.1016/j.diabet.2020.07.006',
'article-title': 'Metformin and COVID-19: from cellular mechanisms to reduced mortality',
'volume': '46',
'author': 'Scheen',
'year': '2020',
'journal-title': 'Diabetes Metab'},
{ 'issue': '7',
'key': '10.1016/j.metabol.2022.155196_bb0425',
'doi-asserted-by': 'crossref',
'first-page': '1480',
'DOI': '10.1007/s00125-021-05458-8',
'article-title': 'Risk phenotypes of diabetes and association with COVID-19 severity and '
'death: a living systematic review and meta-analysis',
'volume': '64',
'author': 'Schlesinger',
'year': '2021',
'journal-title': 'Diabetologia'},
{ 'issue': 'Supplement_1',
'key': '10.1016/j.metabol.2022.155196_bb0430',
'article-title': 'Is metformin use associated with a decreased mortality for COVID-19 '
'diabetic patients? A meta-analysis',
'volume': '5',
'author': 'Sun',
'year': '2021',
'journal-title': 'Journal of the Endocrine Society'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0435',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2021.108977',
'article-title': 'The effect of metformin on mortality and severity in COVID-19 patients '
'with diabetes mellitus',
'volume': '178',
'author': 'Yang',
'year': '2021',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0440',
'article-title': 'Insulin treatment may increase adverse outcomes in patients with '
'COVID-19 and diabetes: a systematic review and meta-analysis',
'volume': '12',
'author': 'Yang',
'year': '2021',
'journal-title': 'Front Endocrinol (Lausanne)'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0445',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.diabres.2020.108183',
'article-title': 'Metformin in COVID-19: a possible role beyond diabetes',
'volume': '164',
'author': 'Sharma',
'year': '2020',
'journal-title': 'Diabetes Res Clin Pract'},
{ 'issue': '8',
'key': '10.1016/j.metabol.2022.155196_bb0450',
'doi-asserted-by': 'crossref',
'first-page': '1167',
'DOI': '10.1172/JCI13505',
'article-title': 'Role of AMP-activated protein kinase in mechanism of metformin action',
'volume': '108',
'author': 'Zhou',
'year': '2001',
'journal-title': 'J Clin Invest'},
{ 'issue': '6',
'key': '10.1016/j.metabol.2022.155196_bb0455',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.ppat.1009634',
'article-title': 'Diabetes and coronavirus (SARS-CoV-2): molecular mechanism of metformin '
'intervention and the scientific basis of drug repurposing',
'volume': '17',
'author': 'Varghese',
'year': '2021',
'journal-title': 'PLoS Pathog'},
{ 'issue': '3',
'key': '10.1016/j.metabol.2022.155196_bb0460',
'doi-asserted-by': 'crossref',
'DOI': '10.1210/endrev/bnaa011',
'article-title': 'Coronavirus infections and Type 2 diabetes-shared pathways with '
'therapeutic implications',
'volume': '41',
'author': 'Drucker',
'year': '2020',
'journal-title': 'Endocr Rev'},
{ 'key': '10.1016/j.metabol.2022.155196_bb0465',
'doi-asserted-by': 'crossref',
'first-page': '3094642',
'DOI': '10.1155/2016/3094642',
'article-title': 'Anti-inflammatory effects of GLP-1-based therapies beyond glucose '
'control',
'volume': '2016',
'author': 'Lee',
'year': '2016',
'journal-title': 'Mediat Inflamm'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0470',
'doi-asserted-by': 'crossref',
'first-page': '405',
'DOI': '10.1016/j.dsx.2020.04.024',
'article-title': 'Can dapagliflozin have a protective effect against COVID-19 infection?A '
'hypothesis',
'volume': '14',
'author': 'Cure',
'year': '2020',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '1',
'key': '10.1016/j.metabol.2022.155196_bb0475',
'doi-asserted-by': 'crossref',
'first-page': '601',
'DOI': '10.1080/22221751.2020.1739565',
'article-title': 'Emerging WuHan (COVID-19) coronavirus: glycan shield and structure '
'prediction of spike glycoprotein and its interaction with human CD26',
'volume': '9',
'author': 'Vankadari',
'year': '2020',
'journal-title': 'Emerg Microbes Infect'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0480',
'doi-asserted-by': 'crossref',
'first-page': '465',
'DOI': '10.1016/S0026-0495(99)90105-1',
'article-title': 'Exogenous hyperinsulinemia causes insulin resistance, '
'hyperendothelinemia, and subsequent hypertension in rats',
'volume': '48',
'author': 'Juan',
'year': '1999',
'journal-title': 'Metabolism'},
{ 'issue': '4',
'key': '10.1016/j.metabol.2022.155196_bb0485',
'doi-asserted-by': 'crossref',
'first-page': '713',
'DOI': '10.1016/j.dsx.2020.05.007',
'article-title': 'Role of oxidized LDL-induced "trained macrophages" in the pathogenesis '
'of COVID-19 and benefits of pioglitazone: a hypothesis',
'volume': '14',
'author': 'Erol',
'year': '2020',
'journal-title': 'Diabetes Metab Syndr'},
{ 'issue': '10',
'key': '10.1016/j.metabol.2022.155196_bb0490',
'doi-asserted-by': 'crossref',
'first-page': '2153',
'DOI': '10.1007/s00125-013-2976-z',
'article-title': 'Pioglitazone improves glucose metabolism and modulates skeletal muscle '
'TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, '
'double-blind, placebo-controlled, mechanistic study',
'volume': '56',
'author': 'Tripathy',
'year': '2013',
'journal-title': 'Diabetologia'}],
'container-title': 'Metabolism',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0026049522000749?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S0026049522000749?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2024, 1, 23]],
'date-time': '2024-01-23T10:18:50Z',
'timestamp': 1706005130000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0026049522000749'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2022, 6]]},
'references-count': 98,
'alternative-id': ['S0026049522000749'],
'URL': 'http://dx.doi.org/10.1016/j.metabol.2022.155196',
'relation': {},
'ISSN': ['0026-0495'],
'subject': [],
'container-title-short': 'Metabolism',
'published': {'date-parts': [[2022, 6]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'Preadmission use of antidiabetic medications and mortality among patients with '
'COVID-19 having type 2 diabetes: A meta-analysis',
'name': 'articletitle',
'label': 'Article Title'},
{'value': 'Metabolism', 'name': 'journaltitle', 'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.metabol.2022.155196',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2022 Elsevier Inc. All rights reserved.',
'name': 'copyright',
'label': 'Copyright'}],
'article-number': '155196'}
