Alkalinization
Analgesics..
Antiandrogens..
Bromhexine
Budesonide
Cannabidiol
Colchicine
Conv. Plasma
Curcumin
Ensovibep
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Iota-carragee..
Ivermectin
Lactoferrin
Lifestyle..
Melatonin
Metformin
Molnupiravir
Monoclonals..
Nigella Sativa
Nitazoxanide
Nitric Oxide
Paxlovid
Peg.. Lambda
Povidone-Iod..
Quercetin
Remdesivir
Vitamins..
Zinc

Other
Feedback
Home
Home   COVID-19 treatment studies for Metformin  COVID-19 treatment studies for Metformin  C19 studies: Metformin  Metformin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 42% Improvement Relative Risk c19early.org/mf Saygili et al. Metformin for COVID-19 Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? PSM retrospective 240 patients in Turkey Lower mortality with metformin (p=0.02) Saygili et al., Irish J. Medical Science, doi:10.1007/s11845-021-02823-9 Favors metformin Favors control

Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period

Saygili et al., Irish Journal of Medical Science, doi:10.1007/s11845-021-02823-9
Saygili et al., Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period, Irish Journal of Medical Science, doi:10.1007/s11845-021-02823-9
Oct 2021   Source   PDF  
  Twitter
  Facebook
Share
  All Studies   Meta
Retrospective 586 diabetic hospitalized COVID-19 patients in Turkey, showing lower mortality with existing metformin use.
risk of death, 41.5% lower, RR 0.58, p = 0.02, treatment 120, control 120, overall mortality, Cox regression in matched group, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Saygili et al., 29 Oct 2021, retrospective, Turkey, peer-reviewed, 5 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperMetforminAll
Preadmission usage of metformin and mortality in COVID-19 patients including the post-discharge period
Emre Sedar Saygili, Ersen Karakiliç, Erdal Mert, Alper Şener, Arzu Mirci
Irish Journal of Medical Science (1971 -), doi:10.1007/s11845-021-02823-9
Background The effect of preadmission metformin usage (PMU) on the mortality of coronavirus disease-2019 (COVID-19) patients with diabetes is conflicting. Most studies have focused on in-hospital mortality; however, mortality after discharge also increases in COVID-19 patients. Aims Examining the effect of PMU on all-cause mortality, including the post-discharge period. Methods Patients with diabetes who were hospitalised in 2020 due to COVID-19 were included in the study. They were divided into two groups: those with a history of metformin use (MF( +)) and those without such history (MF( −)). Propensity score matching (PSM) was performed at a ratio of 1:1 for age and sex. COX regression analyses were used to demonstrate risk factors for mortality. Results We investigated 4103 patients hospitalised for COVID-19. After excluding those without diabetes or with chronic liver/kidney disease, we included the remaining 586 patients, constituting 293 women (50%) with an overall mean age of 66 ± 11.9 years. After PSM analysis, the in-hospital and post-discharge mortality rates were higher in the MF( −) group though not significantly different. However, overall mortality was higher in the MF( −) group (51 (42.5%) vs. 35 (29.2%), p = 0.031). For overall mortality, the adjusted HR was 0.585 (95% CI: 0.371 − 0.920, p = 0.020) in the MF( +) group. Conclusion PMU is associated with reducing all-cause mortality. This effect starts from the in-hospital period and becomes more significant with the post-discharge period. The main limitations were the inability to evaluate the compliance with metformin and the effects of other medications due to retrospective nature.
Declarations Ethics approval The study was approved by the Local Ethics Committee of the Canakkale Onsekiz Mart University Medical School (2011-KAEK-27/2021-E.2100041806). Conflict of interest The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References
Apicella, Campopiano, Mantuano, COVID-19 in people with diabetes: understanding the reasons for worse outcomes, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(20)30238-2
Avogaro, Bonora, Fadini, Managing diabetes in diabetic patients with COVID: where do we start from? Acta Diabetol, doi:10.1007/s00592-021-01739-1
Ayoubkhani, Khunti, Nafilyan, Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study, BMJ, doi:10.1136/bmj.n693
Bailey, Metformin: historical overview, Diabetologia, doi:10.1007/s00125-017-4318-z
Barron, Bakhai, Kar, Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(20)30272-2
Ceriello, Stoian, Rizzo, COVID-19 and diabetes management: what should be considered?, Diabetes Res Clin Pract, doi:10.1016/j.diabres.2020.108151
Chen, Gu, Guan, Metformin might inhibit virus through increasing insulin sensitivity, Chin Med J (Engl), doi:10.4103/0366-6999.223856
Chen, Yang, Cheng, Clinical characteristics and outcomes of patients with diabetes and COVID-19 in association with glucose-lowering medication, Diabetes Care, doi:10.2337/dc20-0660
Cheng, Liu, Li, Metformin is associated with higher incidence of acidosis, but not mortalitY, in individuals with COVID-19 and pre-existing type 2 diabetes, Cell Metab, doi:10.1016/j.cmet.2020.08.013
Dave, Tamuhla, Tiffin, Risk factors for COVID-19 hospitalisation and death in people living with diabetes: a virtual cohort study from the Western Cape Province South Africa Diabetes, Res Clin Pract, doi:10.1016/j.diabres.2021.108925
Do, Kim, Park, Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?, Diabetes Metab, doi:10.1016/j.diabet.2020.10.006
Donnelly, Wang, Iwashyna, Prescott, Readmission and death after initial hospital discharge among patients with COVID-19 in a large multihospital system, JAMA, doi:10.1001/jama.2020.21465
Ghany, Palacio, Dawkins, Metformin is associated with lower hospitalisations, mortality and severe coronavirus infection among elderly medicare minority patients in 8 states in USA, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2021.02.022
Guo, Li, Dong, Diabetes is a risk factor for the progression and prognosis of COVID -19, Diabetes Metab Res Rev, doi:10.1002/dmrr.3319
Hariyanto, Kurniawan, Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection, Obes Med, doi:10.1016/j.obmed.2020.100290
Ho, Huang, Tsai, Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease, Respir Res, doi:10.1186/s12931-019-1035-9
Kajiwara, Kusaka, Kimura, Metformin mediates protection against Legionella pneumonia through activation of AMPK and mitochondrial reactive oxygen species, J Immunol, doi:10.4049/jimmunol.1700474
Khunti, Knighton, Zaccardi, Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00050-4
Kow, Hasan, Mortality risk with preadmission metformin use in patients with COVID-19 and diabetes: a metaanalysis, J Med Virol, doi:10.1002/jmv.26498
Levey, Stevens, Schmid, A new equation to estimate glomerular filtration rate, Ann Intern Med, doi:10.7326/0003-4819-150-9-200905050-00006
Liang, Ding, Li, Association of preadmission metformin use and mortality in patients with sepsis and diabetes mellitus: a systematic review and meta-analysis of cohort studies, Crit Care, doi:10.1186/s13054-019-2346-4
Lukito, Pranata, Henrina, The effect of metformin consumption on mortality in hospitalized COVID-19 patients: a systematic review and meta-analysis, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2020.11.006
Luo, Qiu, Liu, Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis, Am J Trop Med Hyg, doi:10.4269/ajtmh.20-0375
Medetalibeyoglu, Catma, Senkal, The effect of liver test abnormalities on the prognosis of COVID-19, Ann Hepatol, doi:10.1016/j.aohep.2020.08.068
Mendy, Gopal, Alcorn, Forno, Reduced mortality from lower respiratory tract disease in adult diabetic patients treated with metformin, Respirology, doi:10.1111/resp.13486
Mortensen, Anzueto, Association of metformin and mortality for patients with diabetes who are hospitalised with pneumonia
Salık, Uzundere, Bıçak, Liver function as a predictor of mortality in COVID-19 Retrospective study, Ann Hepatol, doi:10.1016/j.aohep.2021.100553
Wang, Cooper, Gokhale, Association of metformin with susceptibility to COVID-19 in people with type 2 diabetes, J Clin Endocrinol Metab, doi:10.1210/clinem/dgab067
Wu, Keet, Fawzy, Association of metformin initiation and risk of asthma exacerbation A claims-based cohort study, Ann Am Thorac Soc, doi:10.1513/AnnalsATS.201812-897OC
Zangiabadian, Nejadghaderi, Zahmatkesh, The efficacy and potential mechanisms of metformin in the treatment of COVID-19 in the diabetics: a systematic review Front, Endocrinol, doi:10.3389/fendo.2021.645194
Zhang, He, Impacts of metformin on tuberculosis incidence and clinical outcomes in patients with diabetes: a systematic review and meta-analysis, Eur J Clin Pharmacol, doi:10.1007/s00228-019-02786-y
Loading..
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit