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All Studies   Meta Analysis    Recent:   

Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection

Hariyanto et al., Obesity Medicine, doi:10.1016/j.obmed.2020.100290
Aug 2020  
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Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
 
*, now known with p < 0.00000000001 from 84 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Meta analysis of 5 studies showing lower mortality with metformin use.
13 meta analyses show significant improvements with metformin for mortality Hariyanto, Kan, Kow, Li, Lukito, Ma, Oscanoa, Parveen, Petrelli, Poly, Schlesinger, Yang, hospitalization Li, progression Yang, and severity Petrelli, Schlesinger.
Currently there are 84 metformin for COVID-19 studies, showing 34% lower mortality [29‑39%], 31% lower ventilation [13‑45%], 17% lower ICU admission [7‑26%], 17% lower hospitalization [11‑23%], and 3% fewer cases [-6‑12%].
Hariyanto et al., 18 Aug 2020, peer-reviewed, 2 authors.
This PaperMetforminAll
Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection
Timotius Ivan Hariyanto, Andree Kurniawan
Obesity Medicine, doi:10.1016/j.obmed.2020.100290
Background and aims: The coronavirus disease 2019 (COVID-19) pandemic has caused a significant impact on all aspects of life. One of the comorbidities associated with severe outcome and mortality of COVID-19 is diabetes. Metformin is one of the drugs which is most commonly used for the treatment of diabetes patients. This study aims to analyze the potential benefit of metformin use in reducing the mortality rate from COVID-19 infection. Methods: We systematically searched the Google Scholar database using specific keywords related to our aims until August 3rd, 2020. All articles published on COVID-19 and metformin were retrieved. Statistical analysis was done using Review Manager 5.4 software. Results: A total of 5 studies with a total of 6937 patients were included in our analysis. Our meta-analysis showed that metformin use is associated with reduction in mortality rate from COVID-19 infections [RR 0.54 (95% CI 0.32-0.90), p = 0.02, I 2 = 54%, random-effect modelling]. Conclusion: Metformin has shown benefits in reducing the mortality rate from COVID-19 infections. Patients with diabetes should be advised to continue taking metformin drugs despite COVID-19 infection status.
References
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Hariyanto, Kurniawan, Dyslipidemia is associated with severe coronavirus disease 2019 (COVID-19) infection, Diabetes Metab Syndr, doi:10.1016/j.dsx.2020.07.054
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