Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication

{ 'indexed': {'date-parts': [[2024, 3, 29]], 'date-time': '2024-03-29T14:33:45Z', 'timestamp': 1711722825870}, 'reference-count': 28, 'publisher': 'American Diabetes Association', 'issue': '7', 'license': [ { 'start': { 'date-parts': [[2020, 6, 19]], 'date-time': '2020-06-19T00:00:00Z', 'timestamp': 1592524800000}, 'content-version': 'vor', 'delay-in-days': 36, 'URL': 'https://www.diabetesjournals.org/content/license'}], 'funder': [ { 'DOI': '10.13039/501100012166', 'name': 'National Key R&D Program of China', 'doi-asserted-by': 'crossref', 'award': ['2019YFA0802701', '2018YFA0800700']}, { 'DOI': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'doi-asserted-by': 'publisher', 'award': ['91957114', '31971066', '31871381', '31671195']}, {'name': 'Family Planning Commission of Wuhan', 'award': ['WX18M02']}], 'content-domain': {'domain': ['diabetesjournals.org'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2020, 7, 1]]}, 'abstract': '<jats:sec>\n' ' <jats:title>OBJECTIVE</jats:title>\n' ' <jats:p>Diabetes is one of the most distinct comorbidities of COVID-19. ' 'Here, we describe the clinical characteristics of and outcomes in patients with diabetes in ' 'whom COVID-19 was confirmed or clinically diagnosed (with typical features on lung imaging ' 'and symptoms) and their association with glucose-lowering or blood pressure–lowering ' 'medications.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>RESEARCH DESIGN AND METHODS</jats:title>\n' ' <jats:p>In this retrospective study involving 904 patients with COVID-19 ' '(136 with diabetes, mostly type 2 diabetes), clinical and laboratory characteristics were ' 'collected and compared between the group with diabetes and the group without diabetes, and ' 'between groups taking different medications. Logistic regression was used to explore risk ' 'factors associated with mortality or poor prognosis.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>RESULTS</jats:title>\n' ' <jats:p>The proportion of comorbid diabetes is similar between cases of ' 'confirmed and of clinically diagnosed COVID-19. Risk factors for higher mortality of patients ' 'with diabetes and COVID-19 were older age (adjusted odds ratio [aOR] 1.09 [95% CI 1.04, 1.15] ' 'per year increase; P = 0.001) and elevated C-reactive protein (aOR 1.12 [95% CI 1.00, 1.24]; ' 'P = 0.043). Insulin usage (aOR 3.58 [95% CI 1.37, 9.35]; P = 0.009) was associated with poor ' 'prognosis. Clinical outcomes of those who use an ACE inhibitor (ACEI) or angiotensin II ' 'type-I receptor blocker (ARB) were comparable with those of patients who do not use ACEI/ARB ' 'among COVID-19 patients with diabetes and hypertension.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>CONCLUSIONS</jats:title>\n' ' <jats:p>C-reactive protein may help to identify patients with diabetes who ' 'are at greater risk of dying during hospitalization. Older patients with diabetes were prone ' 'to death related to COVID-19. Attention needs to be paid to patients with diabetes and ' 'COVID-19 who use insulin. ACEI/ARB use showed no significant impact on patients with diabetes ' 'and hypertension who have COVID-19.</jats:p>\n' ' </jats:sec>', 'DOI': '10.2337/dc20-0660', 'type': 'journal-article', 'created': {'date-parts': [[2020, 5, 14]], 'date-time': '2020-05-14T18:16:51Z', 'timestamp': 1589480211000}, 'page': '1399-1407', 'update-policy': 'http://dx.doi.org/10.2337/ada-journal-policies', 'source': 'Crossref', 'is-referenced-by-count': 295, 'title': 'Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With ' 'Glucose-Lowering Medication', 'prefix': '10.2337', 'volume': '43', 'author': [ { 'given': 'Yuchen', 'family': 'Chen', 'sequence': 'first', 'affiliation': [ { 'name': 'Tongji School of Pharmacy, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Dong', 'family': 'Yang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Tongji School of Pharmacy, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Biao', 'family': 'Cheng', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy and the Center of Information, The ' 'Central Hospital of Wuhan, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Jian', 'family': 'Chen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy and the Center of Information, The ' 'Central Hospital of Wuhan, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Anlin', 'family': 'Peng', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy, The Third Hospital of Wuhan, Wuhan, ' 'China'}]}, { 'given': 'Chen', 'family': 'Yang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Tongji School of Pharmacy, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Chong', 'family': 'Liu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Hubei Key Laboratory of Cell Homeostasis, College of Life ' 'Sciences, Wuhan University, Wuhan, China'}]}, { 'given': 'Mingrui', 'family': 'Xiong', 'sequence': 'additional', 'affiliation': [ { 'name': 'Tongji School of Pharmacy, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Aiping', 'family': 'Deng', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Pharmacy and the Center of Information, The ' 'Central Hospital of Wuhan, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'given': 'Yu', 'family': 'Zhang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Tongji School of Pharmacy, Tongji Medical College, Huazhong ' 'University of Science and Technology, Wuhan, China'}]}, { 'ORCID': 'http://orcid.org/0000-0002-7918-6682', 'authenticated-orcid': False, 'given': 'Ling', 'family': 'Zheng', 'sequence': 'additional', 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'Advanced and Specialized Nursing', 'Endocrinology, Diabetes and Metabolism', 'Internal Medicine'], 'published': {'date-parts': [[2020, 5, 14]]}}