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0 0.5 1 1.5 2+ Mortality 31% Improvement Relative Risk Severe case 22% c19early.org/mf Schlesinger et al. Metformin for COVID-19 META Favors metformin Favors control

Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic review and meta-analysis

Schlesinger et al., Diabetologia, doi:10.1007/s00125-023-05928-1
Schlesinger et al., Risk phenotypes of diabetes and association with COVID-19 severity and death: an update of a living systematic.., Diabetologia, doi:10.1007/s00125-023-05928-1
May 2023   Source   PDF  
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Systematic review and meta analysis showing significantly lower COVID-19 mortality and severity with metformin use. Authors analyze 169 studies of diabetes patients, with 23 reporting mortality results and 34 reporting severity results for metformin.
Currently there are 65 metformin studies and meta analysis shows:
OutcomeImprovement
Mortality32% lower [27‑37%]
Ventilation30% lower [11‑44%]
ICU admission17% lower [5‑28%]
Hospitalization18% lower [10‑24%]
Cases4% fewer [-6‑13%]
risk of death, 31.0% lower, RR 0.69, p < 0.001.
risk of severe case, 22.0% lower, RR 0.78, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Schlesinger et al., 19 May 2023, peer-reviewed, 10 authors.
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