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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 74% Improvement Relative Risk Ventilation 25% c19early.org/mf Ma et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Metformin is associated with favorable outcomes in patients with COVID-19 and type 2 diabetes mellitus
Ma et al., Scientific Reports, doi:10.1038/s41598-022-09639-2
1 Apr 2022    Source   PDF   Share   Tweet
PSM/IPTW retrospective 1,356 hospitalized COVID-19 patients with type 2 diabetes in China, showing lower mortality/hospice with metformin use.
risk of death, 74.2% lower, RR 0.26, p = 0.03, treatment 3 of 361 (0.8%), control 40 of 995 (4.0%), NNT 31, odds ratio converted to relative risk, in-hospital death or hospice, propensity score weighting.
risk of mechanical ventilation, 25.0% lower, RR 0.75, p = 0.44, treatment 12 of 360 (3.3%), control 16 of 360 (4.4%), NNT 90, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ma et al., 1 Apr 2022, retrospective, USA, peer-reviewed, 4 authors, study period 16 March, 2020 - 15 February, 2021.
Contact: mahesh.krishnamurthy@sluhn.org.
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