Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
Xu Cheng, Ye-Mao Liu, Haomiao Li, Xin Zhang, Fang Lei, Juan-Juan Qin, Ze Chen, Ke-Qiong Deng, Lijin Lin, Ming-Ming Chen, Xiaohui Song, Meng Xia, Xuewei Huang, Weifang Liu, Jingjing Cai, Xiao-Jing Zhang, Feng Zhou, Peng Zhang, Yibin Wang, Xinliang Ma, Qingbo Xu, Juan Yang, Ping Ye, Weiming Mao, Xiaodong Huang, Jiahong Xia, Bing-Hong Zhang, Jiao Guo, Lihua Zhu, Zhibing Lu, Yufeng Yuan, Xiang Wei, Zhi-Gang She, Yan-Xiao Ji, Hongliang Li
Cell Metabolism, doi:10.1016/j.cmet.2020.08.013
Highlights d A retrospective study of 1,213 patients on metformin with COVID-19 was performed d Metformin was associated with increased incidence of acidosis in such patients d Metformin was not associated with increased 28-day allcause mortality in the patients d Metformin was significantly associated with reduced heart failure and inflammation
AUTHOR CONTRIBUTIONS X.C., Y.-M.L., Haomiao Li, X.Z., and F.L. designed the study, collected and analyzed data, and wrote the manuscript. Z.C., K.-Q.D., L.L., M.-M.C., X.S., M.X., Xuewei Huang, W.L., P.Z., P.Y., W.M., Xiaodong Huang, J.X., B.-H.Z., J.G., L.Z., and Z.L. collected, reviewed, interpreted, and checked clinical, laboratory, and radiological data. J.-J.Q. and F.Z. performed the statistical analysis. J.C., X.-J.Z., Y.W., X.M., Q.X., X.Z., and J.Y. wrote and edited the manuscript and provided valuable suggestions for study design and data analysis. Y.Y., X.W., Z.-G.S., Y.-X.J., and Hongliang Li contributed equally, designed the project, edited manuscript, and supervised the study. All authors have approved the final version of this paper.
DECLARATION OF INTERESTS We have no competing interests to declare.
Supplementary Information
Metformin Is Associated with Higher Incidence of Acidosis, but not Mortality, in Individuals Abbreviation: SBP, systolic blood pressure; DBP, Diastolic blood pressure; SpO2, oxygen saturation; RBC, red blood cells; ALT, alanine aminotransferase; eGFR, estimated glomerular filtration rate; LDL-c, low density lipoprotein cholesterol; IQR, interquartile range; SD, standardized difference. a Upper limit of normal (ULN) was defined according to criteria in each hospital. b Individuals with T2D taking Metformin during hospitalization were enrolled in the Metformin cohort. Individuals discontinued treatment of diabetes due to inability to..
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