Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes
Cheng et al.,
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and..,
Cell Metabolism, doi:10.1016/j.cmet.2020.08.013
Retrospective 1,213 hospitalized diabetic COVID-19 patients in China, showing no significant difference in mortality with pre-existing metformin use.
risk of death, 65.0% higher, HR 1.65, p = 0.25, treatment 678, control 535, after PSM.
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Cheng et al., 20 Aug 2021, retrospective, propensity score matching, China, peer-reviewed, 35 authors.
Abstract: Clinical and Translational Report
Metformin Is Associated with Higher Incidence of
Acidosis, but Not Mortality, in Individuals with
COVID-19 and Pre-existing Type 2 Diabetes
Graphical Abstract
Authors
Xu Cheng, Ye-Mao Liu, Haomiao Li, ...,
Zhi-Gang She, Yan-Xiao Ji,
Hongliang Li
Correspondence
lihl@whu.edu.cn (H.L.),
yuanyf1971@whu.edu.cn (Y.Y.),
xiangwei@tjh.tjmu.edu.cn (X.W.),
zgshe@whu.edu.cn (Z.-G.S.),
jiyanxiao@whu.edu.cn (Y.-X.J.)
In Brief
In a cohort of 1,213 hospitalized patients
with COVID-19 and pre-existing type 2
diabetes, Cheng et al. show that
metformin use is significantly associated
with higher incidence of acidosis,
particularly in cases with severe COVID19, but not with 28-day all-cause
mortality. They also found that metformin
use is significantly associated with
reduced heart failure and inflammation.
Highlights
d
A retrospective study of 1,213 patients on metformin with
COVID-19 was performed
d
Metformin was associated with increased incidence of
acidosis in such patients
d
Metformin was not associated with increased 28-day allcause mortality in the patients
d
Metformin was significantly associated with reduced heart
failure and inflammation
Cheng et al., 2020, Cell Metabolism 32, 537–547
October 6, 2020 ª 2020 Elsevier Inc.
https://doi.org/10.1016/j.cmet.2020.08.013
ll
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Clinical and Translational Report
Metformin Is Associated with Higher Incidence
of Acidosis, but Not Mortality, in Individuals
with COVID-19 and Pre-existing Type 2 Diabetes
Xu Cheng,1,2,17 Ye-Mao Liu,2,3,17 Haomiao Li,2,3,17 Xin Zhang,2,17 Fang Lei,1,2,17 Juan-Juan Qin,2,3 Ze Chen,2,3
Ke-Qiong Deng,1 Lijin Lin,2,3 Ming-Ming Chen,2,3 Xiaohui Song,2,3 Meng Xia,2 Xuewei Huang,2,3 Weifang Liu,1,2
Jingjing Cai,4 Xiao-Jing Zhang,2,3 Feng Zhou,2,5 Peng Zhang,2,5 Yibin Wang,6 Xinliang Ma,7 Qingbo Xu,8 Juan Yang,2,3
Ping Ye,9 Weiming Mao,10 Xiaodong Huang,11 Jiahong Xia,12 Bing-Hong Zhang,13 Jiao Guo,14 Lihua Zhu,2,3 Zhibing Lu,1
Yufeng Yuan,15,* Xiang Wei,16,* Zhi-Gang She,2,3,* Yan-Xiao Ji,2,5,* and Hongliang Li1,2,3,5,18,*
1Department
of Cardiology, Zhongnan Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
of Model Animal, Wuhan University, Wuhan, China
3Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
4Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China
5Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China
6Departments of Anesthesiology, Physiology, and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine,
University of California, Los Angeles, Los Angeles, CA, USA
7Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA
8Centre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London, UK
9Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan, China
10Department of General Surgery, Huanggang Central Hospital, Huanggang, China
11Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China
12Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan, China
13Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China
14Guangdong Metabolic Diseases Research Center of Integrated Chinese..
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