Outpatient metformin use is associated with reduced severity of COVID‐19 disease in adults with overweight or obesity
MD, MPH Carolyn T Bramante, MD John Buse, MD Leonardo Tamaritz, MD Ana Palacio, MD Ken Cohen, Deneen Vojta, MD David Liebovitz, MD, MPH Nia Mitchell, MD Jacinda Nicklas, MD, MPH, MSCS Ildiko Lingvay, MD, MPH Jeanne M Clark, Louis J Aronne, MD, MPH Erik Anderson, Michael Usher, PhD, MPH Ryan Demmer, MD Genevieve B Melton, MD Nicholas Ingraham, Christopher J Tignanelli
Journal of Medical Virology, doi:10.1002/jmv.26873
Observational studies suggest outpatient metformin use is associated with reduced mortality from coronavirus disease-2019 (COVID-19). Metformin is known to decrease interleukin-6 and tumor-necrosis factor-α, which appear to contribute to morbidity in COVID-19. We sought to understand whether outpatient metformin use was associated with reduced odds of severe COVID-19 disease in a large US healthcare data set. Retrospective cohort analysis of electronic health record (EHR) data that was pooled across This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
AUTHOR CONTRIBUTIONS Dr. Tignanelli is the guarantor with responsibility for the work as a whole given his full access to the data. Carolyn T. Bramante Michael Usher contributed to design and analysis. Ryan Demmer contributed to design, analysis, and critical review. Genevieve B. Melton contributed to design and analysis and writing. Nicholas Ingraham contributed to analysis and writing. Christopher J. Tignanelli contributed to study design, analysis, interpretation, and critical review.
SUPPORTING INFORMATION Additional Supporting Information may be found online in the supporting information tab for this article.
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