Outpatient metformin use is associated with reduced severity of COVID‐19 disease in adults with overweight or obesity
Bramante et al.,
Outpatient metformin use is associated with reduced severity of COVID‐19 disease in adults with overweight or..,
Journal of Medical Virology, doi:10.1002/jmv.26873
Retrospective 17,396 PCR+ patients in the USA, showing lower mortality with metformin use.
risk of death, 62.0% lower, OR 0.38, p = 0.03, treatment 342, control 342, propensity score matching, RR approximated with OR.
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risk of death, 68.0% lower, OR 0.32, p = 0.003, treatment 676, control 8,879, adjusted per study, multivariable, RR approximated with OR.
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risk of ICU admission, 9.0% higher, OR 1.09, p = 0.78, treatment 342, control 342, propensity score matching, RR approximated with OR.
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risk of ICU admission, 32.0% lower, OR 0.68, p = 0.06, treatment 676, control 8,879, adjusted per study, multivariable, RR approximated with OR.
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risk of hospitalization, 22.0% lower, OR 0.78, p = 0.10, treatment 676, control 8,879, adjusted per study, multivariable, RR approximated with OR.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Bramante et al., 23 Mar 2021, retrospective, USA, peer-reviewed, 18 authors, study period 4 March, 2020 - 4 December, 2020.
Contact:
bramante@umn.edu.
Abstract: | Revised: 8 February 2021 | Accepted: 10 February 2021
DOI: 10.1002/jmv.26873
RESEARCH ARTICLE
Outpatient metformin use is associated with reduced severity
of COVID‐19 disease in adults with overweight or obesity
Carolyn T. Bramante MD, MPH1
| John Buse MD, PhD2 |
Leonardo Tamaritz MD3 | Ana Palacio MD, MPH3 | Ken Cohen MD4 |
Deneen Vojta MD4 | David Liebovitz MD5 | Nia Mitchell MD, MPH6 |
Jacinda Nicklas MD, MPH7 | Ildiko Lingvay MD, MPH, MSCS8,9 |
Jeanne M. Clark MD, MPH10 | Louis J. Aronne MD11 | Erik Anderson MD, MPH12
1
|
Michael Usher MD, PhD | Ryan Demmer PhD, MPH
Genevieve B. Melton MD, PhD14 | Nicholas Ingraham MD15
Christopher J. Tignanelli MD
|
13
|
14
1
Department of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA
2
Department of Medicine, Division of Endocrinology, University of North Carolina, Chapel Hill, North Carolina, USA
3
Humana Health Services Research Center, Miami University, Miami, Florida, USA
4
UnitedHealth Group Research and Development, Minnetonka, Minnesota, USA
5
Department of Medicine Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
6
Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
7
Department of Medicine, Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA
8
Department of Medicine/Endocrinology, UT Southwestern Medical Center, Dallas, Texas, USA
9
Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, Texas, USA
10
Department of Medicine, Division of General Internal Medicine, John Hopkins, Baltimore, Maryland, USA
11
Department of Medicine, Weill Cornell Medicine, New York, New York, USA
12
Department of Emergency Medicine, Alameda County, Oakland, California, USA
13
Department of Epidemiology, Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
14
Department of Medicine, Division of Pulmonary Medicine, University of Minnesota, Minneapolis, Minnesota, USA
15
Department of Surgery, Division of Surgical Oncology, University of Minnesota, Minneapolis, Minnesota, USA
Correspondence
Carolyn T. Bramante, MD, MPH, 420 Delaware
St SE, MMC 276, Minneapolis, MN 55455,
USA.
Email: bramante@umn.edu
Abstract
Observational studies suggest outpatient metformin use is associated with reduced
mortality from coronavirus disease‐2019 (COVID‐19). Metformin is known to decrease
interleukin‐6 and tumor‐necrosis factor‐α, which appear to contribute to morbidity in
Funding information
Agency for Healthcare Research and Quality,
Grant/Award Number: K12HS026379; UMN
Rapid Response Covid Grant,
Grant/Award Number: UM 2020‐2231;
COVID‐19. We sought to understand whether outpatient metformin use was associated
with reduced odds of severe COVID‐19 disease in a large US healthcare data set. Retrospective cohort analysis of electronic health record (EHR) data that was pooled across
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any
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© 2021 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC
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