Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19

DOI record: { "DOI": "10.1016/j.diabet.2020.101216", "ISSN": [ "1262-3636" ], "URL": "http://dx.doi.org/10.1016/j.diabet.2020.101216", "alternative-id": [ "S1262363620302731" ], "article-number": "101216", "assertion": [ { "label": "This article is maintained by", "name": "publisher", "value": "Elsevier" }, { "label": "Article Title", "name": "articletitle", "value": "Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19" }, { "label": "Journal Title", "name": "journaltitle", "value": "Diabetes & Metabolism" }, { "label": "CrossRef DOI link to publisher maintained version", "name": "articlelink", "value": "https://doi.org/10.1016/j.diabet.2020.101216" }, { "label": "Content Type", "name": "content_type", "value": "article" }, { "label": "Copyright", "name": "copyright", "value": "© 2020 Elsevier Masson SAS. All rights reserved." } ], "author": [ { "affiliation": [], "family": "Lalau", "given": "Jean-Daniel", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-7951-9926", "affiliation": [], "authenticated-orcid": false, "family": "Al-Salameh", "given": "Abdallah", "sequence": "additional" }, { "affiliation": [], "family": "Hadjadj", "given": "Samy", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-1019-9821", "affiliation": [], "authenticated-orcid": false, "family": "Goronflot", "given": "Thomas", "sequence": "additional" }, { "affiliation": [], "family": "Wiernsperger", "given": "Nicolas", "sequence": "additional" }, { "affiliation": [], "family": "Pichelin", "given": "Matthieu", "sequence": "additional" }, { "affiliation": [], "family": "Allix", "given": "Ingrid", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-0581-7592", "affiliation": [], "authenticated-orcid": false, "family": "Amadou", "given": "Coralie", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-7348-7161", "affiliation": [], "authenticated-orcid": false, "family": "Bourron", "given": "Olivier", "sequence": "additional" }, { "affiliation": [], "family": "Duriez", "given": "Thierry", "sequence": "additional" }, { "affiliation": [], "family": "Gautier", "given": "Jean-François", "sequence": "additional" }, { "affiliation": [], "family": "Dutour", "given": "Anne", "sequence": "additional" }, { "affiliation": [], "family": "Gonfroy", "given": "Céline", "sequence": "additional" }, { "affiliation": [], "family": "Gouet", "given": "Didier", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-8731-7355", "affiliation": [], "authenticated-orcid": false, "family": "Joubert", "given": "Michael", "sequence": "additional" }, { "affiliation": [], "family": "Julier", "given": "Ingrid", "sequence": "additional" }, { "affiliation": [], "family": "Larger", "given": "Etienne", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9101-5002", "affiliation": [], "authenticated-orcid": false, "family": "Marchand", "given": "Lucien", "sequence": "additional" }, { "affiliation": [], "family": "Marre", "given": "Michel", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3687-5522", "affiliation": [], "authenticated-orcid": false, "family": "Meyer", "given": "Laurent", "sequence": "additional" }, { "affiliation": [], "family": "Olivier", "given": "Frédérique", "sequence": "additional" }, { "affiliation": [], "family": "Prevost", "given": "Gaëtan", "sequence": "additional" }, { "affiliation": [], "family": "Quiniou", "given": "Pascale", "sequence": "additional" }, { "affiliation": [], "family": "Raffaitin-Cardin", "given": "Christelle", "sequence": "additional" }, { "affiliation": [], "family": "Roussel", "given": "Ronan", "sequence": "additional" }, { "affiliation": [], "family": "Saulnier", "given": "Pierre-Jean", "sequence": "additional" }, { "affiliation": [], "family": "Seret-Begue", "given": "Dominique", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-0696-974X", "affiliation": [], "authenticated-orcid": false, "family": "Thivolet", "given": "Charles", "sequence": "additional" }, { "affiliation": [], "family": "Vatier", "given": "Camille", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-9976-7938", "affiliation": [], "authenticated-orcid": false, "family": "Desailloud", "given": "Rachel", "sequence": "additional" }, { "affiliation": [], "family": "Wargny", "given": "Matthieu", "sequence": "additional" }, { "affiliation": [], "family": "Gourdy", "given": "Pierre", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-1580-8040", "affiliation": [], "authenticated-orcid": false, "family": "Cariou", "given": "Bertrand", "sequence": "additional" } ], "container-title": [ "Diabetes & Metabolism" ], "content-domain": { "crossmark-restriction": true, "domain": [ "clinicalkey.jp", "clinicalkey.com", "clinicalkey.es", "clinicalkey.fr", "clinicalkey.com.au", "elsevier.com", "sciencedirect.com" ] }, "created": { "date-parts": [ [ 2020, 12, 10 ] ], "date-time": "2020-12-10T18:01:01Z", "timestamp": 1607623261000 }, "deposited": { "date-parts": [ [ 2021, 11, 4 ] ], "date-time": "2021-11-04T01:17:24Z", "timestamp": 1635988644000 }, "funder": [ { "DOI": "10.13039/501100009406", "doi-asserted-by": "publisher", "name": "Centre Hospitalier Universitaire de Nantes" }, { "DOI": "10.13039/501100008966", "doi-asserted-by": "publisher", "name": "Société Francophone du Diabète" } ], "indexed": { "date-parts": [ [ 2022, 1, 9 ] ], "date-time": "2022-01-09T01:26:15Z", "timestamp": 1641691575407 }, "is-referenced-by-count": 19, "issn-type": [ { "type": "print", "value": "1262-3636" } ], "issue": "5", "issued": { "date-parts": [ [ 2021, 9 ] ] }, "journal-issue": { "issue": "5", "published-print": { "date-parts": [ [ 2021, 9 ] ] } }, "language": "en", "license": [ { "URL": "https://www.elsevier.com/tdm/userlicense/1.0/", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 9, 1 ] ], "date-time": "2021-09-01T00:00:00Z", "timestamp": 1630454400000 } } ], "link": [ { "URL": "https://api.elsevier.com/content/article/PII:S1262363620302731?httpAccept=text/xml", "content-type": "text/xml", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://api.elsevier.com/content/article/PII:S1262363620302731?httpAccept=text/plain", "content-type": "text/plain", "content-version": "vor", "intended-application": "text-mining" } ], "member": "78", "original-title": [], "page": "101216", "prefix": "10.1016", "published": { "date-parts": [ [ 2021, 9 ] ] }, "published-print": { "date-parts": [ [ 2021, 9 ] ] }, "publisher": "Elsevier BV", "reference": [ { "DOI": "10.1038/s41586-020-2521-4", "article-title": "Factors associated with COVID-19-related death using OpenSAFELY", "author": "Williamson", "doi-asserted-by": "crossref", "first-page": "430", "journal-title": "Nature", "key": "10.1016/j.diabet.2020.101216_bib0005", "volume": "584", "year": "2020" }, { "DOI": "10.2337/dci19-0066", "article-title": "2019 Update to: management of hyperglycemia in Type 2 diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)", "author": "Buse", "doi-asserted-by": "crossref", "first-page": "487", "journal-title": "Diabetes Care", "key": "10.1016/j.diabet.2020.101216_bib0010", "volume": "43", "year": "2020" }, { "DOI": "10.7326/M15-2650", "article-title": "Diabetes Medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis", "author": "Maruthur", "doi-asserted-by": "crossref", "first-page": "740", "journal-title": "Ann Intern Med", "key": "10.1016/j.diabet.2020.101216_bib0015", "volume": "164", "year": "2016" }, { "DOI": "10.1159/000481951", "article-title": "Renoprotective effects of metformin", "author": "De Broe", "doi-asserted-by": "crossref", "first-page": "261", "journal-title": "Nephron", "key": "10.1016/j.diabet.2020.101216_bib0020", "volume": "138", "year": "2018" }, { "DOI": "10.1007/s00125-017-4372-6", "article-title": "Repurposing metformin for the prevention of cancer and cancer recurrence", "author": "Heckman-Stoddard", "doi-asserted-by": "crossref", "first-page": "1639", "journal-title": "Diabetologia", "key": "10.1016/j.diabet.2020.101216_bib0025", "volume": "60", "year": "2017" }, { "DOI": "10.3389/fendo.2018.00400", "article-title": "The therapeutic potential of metformin in neurodegenerative diseases", "author": "Rotermund", "doi-asserted-by": "crossref", "first-page": "400", "journal-title": "Front Endocrinol", "key": "10.1016/j.diabet.2020.101216_bib0030", "volume": "9", "year": "2018" }, { "DOI": "10.1016/j.cmet.2020.04.001", "article-title": "Benefits of metformin in attenuating the hallmarks of aging", "author": "Kulkarni", "doi-asserted-by": "crossref", "first-page": "15", "journal-title": "Cell Metab", "key": "10.1016/j.diabet.2020.101216_bib0035", "volume": "32", "year": "2020" }, { "article-title": "Metformin as a cellular protector; a synoptic view of modern evidences", "author": "Wiernsperger", "first-page": "31", "journal-title": "J Nephropharmacology", "key": "10.1016/j.diabet.2020.101216_bib0040", "volume": "4", "year": "2015" }, { "DOI": "10.1038/s41574-019-0242-2", "article-title": "Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus", "author": "Foretz", "doi-asserted-by": "crossref", "first-page": "569", "journal-title": "Nat Rev Endocrinol", "key": "10.1016/j.diabet.2020.101216_bib0045", "volume": "15", "year": "2019" }, { "DOI": "10.1186/s13054-019-2346-4", "article-title": "Association of preadmission metformin use and mortality in patients with sepsis and diabetes mellitus: a systematic review and meta-analysis of cohort studies", "author": "Liang", "doi-asserted-by": "crossref", "first-page": "50", "journal-title": "Crit Care Lond Engl", "key": "10.1016/j.diabet.2020.101216_bib0050", "volume": "23", "year": "2019" }, { "DOI": "10.1007/s00125-017-4318-z", "article-title": "Metformin: historical overview", "author": "Bailey", "doi-asserted-by": "crossref", "first-page": "1566", "journal-title": "Diabetologia", "key": "10.1016/j.diabet.2020.101216_bib0055", "volume": "60", "year": "2017" }, { "DOI": "10.1002/dmrr.2975", "article-title": "Is metformin poised for a second career as an antimicrobial?", "author": "Malik", "doi-asserted-by": "crossref", "first-page": "e2975", "journal-title": "Diabetes Metab Res Rev", "key": "10.1016/j.diabet.2020.101216_bib0060", "volume": "34", "year": "2018" }, { "DOI": "10.1038/s41586-020-2286-9", "article-title": "A SARS-CoV-2 protein interaction map reveals targets for drug repurposing", "author": "Gordon", "doi-asserted-by": "crossref", "first-page": "459", "journal-title": "Nature", "key": "10.1016/j.diabet.2020.101216_bib0065", "volume": "583", "year": "2020" }, { "DOI": "10.1016/j.tips.2020.01.003", "article-title": "Context-dependent pharmacological effects of metformin on the immune system", "author": "Marcucci", "doi-asserted-by": "crossref", "first-page": "162", "journal-title": "Trends Pharmacol Sci", "key": "10.1016/j.diabet.2020.101216_bib0070", "volume": "41", "year": "2020" }, { "DOI": "10.1161/CIRCRESAHA.116.308445", "article-title": "Anti-inflammatory effects of metformin irrespective of diabetes status", "author": "Cameron", "doi-asserted-by": "crossref", "first-page": "652", "journal-title": "Circ Res", "key": "10.1016/j.diabet.2020.101216_bib0075", "volume": "119", "year": "2016" }, { "DOI": "10.18632/aging.103347", "article-title": "Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19", "author": "Menendez", "doi-asserted-by": "crossref", "first-page": "8760", "journal-title": "Aging", "key": "10.1016/j.diabet.2020.101216_bib0080", "volume": "12", "year": "2020" }, { "DOI": "10.1038/s41467-019-10839-0", "article-title": "Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis", "author": "Kheirollahi", "doi-asserted-by": "crossref", "first-page": "2987", "journal-title": "Nat Commun", "key": "10.1016/j.diabet.2020.101216_bib0085", "volume": "10", "year": "2019" }, { "DOI": "10.1016/S2213-8587(20)30231-X", "article-title": "Management of diabetes in patients with COVID-19", "author": "Lalau", "doi-asserted-by": "crossref", "first-page": "666", "journal-title": "Lancet Diabetes Endocrinol", "key": "10.1016/j.diabet.2020.101216_bib0090", "volume": "8", "year": "2020" }, { "article-title": "Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study", "author": "Cariou", "journal-title": "Diabetologia", "key": "10.1016/j.diabet.2020.101216_bib0095", "year": "2020" }, { "DOI": "10.1002/sim.3854", "article-title": "The performance of different propensity-score methods for estimating differences in proportions (risk differences or absolute risk reductions) in observational studies", "author": "Austin", "doi-asserted-by": "crossref", "first-page": "2137", "journal-title": "Stat Med", "key": "10.1016/j.diabet.2020.101216_bib0100", "volume": "29", "year": "2010" }, { "DOI": "10.1177/0272989X09341755", "article-title": "The relative ability of different propensity score methods to balance measured covariates between treated and untreated subjects in observational studies", "author": "Austin", "doi-asserted-by": "crossref", "first-page": "661", "journal-title": "Med Decis Mak Int J Soc Med Decis Mak", "key": "10.1016/j.diabet.2020.101216_bib0105", "volume": "29", "year": "2009" }, { "author": "Mao", "key": "10.1016/j.diabet.2020.101216_bib0110", "series-title": "Propensity score weighting methods for dichotomous treatments", "year": "2018" }, { "DOI": "10.1161/CIRCULATIONAHA.120.047022", "article-title": "COVID-19 and renin angiotensin blockers: current evidence and recommendations", "author": "Messerli", "doi-asserted-by": "crossref", "first-page": "2042", "journal-title": "Circulation", "key": "10.1016/j.diabet.2020.101216_bib0115", "volume": "141", "year": "2020" }, { "article-title": "Routine use of statins and increased mortality related to COVID-19 in inpatients with type 2 diabetes: results from the CORONADO study", "author": "Cariou", "journal-title": "Diabetes Metab", "key": "10.1016/j.diabet.2020.101216_bib0120", "year": "2020" }, { "DOI": "10.1016/S1262-3636(07)70037-X", "article-title": "Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects", "author": "Robert", "doi-asserted-by": "crossref", "first-page": "279", "journal-title": "Diabetes Metab", "key": "10.1016/j.diabet.2020.101216_bib0125", "volume": "29", "year": "2003" }, { "DOI": "10.1016/j.diabet.2020.07.006", "article-title": "Metformin and COVID-19: from cellular mechanisms to reduced mortality", "author": "Scheen", "doi-asserted-by": "crossref", "journal-title": "Diabetes Metab", "key": "10.1016/j.diabet.2020.101216_bib0130", "year": "2020" }, { "DOI": "10.1016/j.diabres.2020.108268", "article-title": "Is metformin ahead in the race as a repurposed host-directed therapy for patients with diabetes and COVID-19?", "author": "Singh", "doi-asserted-by": "crossref", "journal-title": "Diabetes Res Clin Pract", "key": "10.1016/j.diabet.2020.101216_bib0135", "volume": "165", "year": "2020" }, { "DOI": "10.1016/j.obmed.2020.100290", "article-title": "Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection", "author": "Hariyanto", "doi-asserted-by": "crossref", "first-page": "100290", "journal-title": "Obes Med", "key": "10.1016/j.diabet.2020.101216_bib0140", "volume": "19", "year": "2020" }, { "DOI": "10.4269/ajtmh.20-0375", "article-title": "Metformin treatment was associated with decreased mortality in Covid-19 patients with diabetes in a retrospective analysis", "author": "Luo", "doi-asserted-by": "crossref", "first-page": "69", "journal-title": "Am J Trop Med Hyg", "key": "10.1016/j.diabet.2020.101216_bib0145", "volume": "103", "year": "2020" }, { "article-title": "Observational study of metformin and risk of mortality in patients hospitalized with Covid-19", "author": "Bramante", "journal-title": "MedRxiv Prepr Serv Health Sci", "key": "10.1016/j.diabet.2020.101216_bib0150", "year": "2020" }, { "article-title": "Metformin use is associated with reduced mortality in a diverse population with covid-19 and diabetes", "author": "Crouse", "journal-title": "MedRxiv Prepr Serv Health Sci", "key": "10.1016/j.diabet.2020.101216_bib0155", "year": "2020" }, { "DOI": "10.1016/j.cmet.2020.08.013", "article-title": "Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with Covid-19 and pre-existing type 2 diabetes", "author": "Cheng", "doi-asserted-by": "crossref", "first-page": "537", "journal-title": "Cell Metab", "key": "10.1016/j.diabet.2020.101216_bib0160", "volume": "32", "year": "2020" }, { "article-title": "Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?", "author": "Do", "journal-title": "Diabetes Metab", "key": "10.1016/j.diabet.2020.101216_bib0165", "year": "2020" }, { "DOI": "10.1186/s12916-020-01832-2", "article-title": "Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study", "author": "Pérez-Belmonte", "doi-asserted-by": "crossref", "first-page": "359", "journal-title": "BMC Med", "key": "10.1016/j.diabet.2020.101216_bib0170", "volume": "18", "year": "2020" }, { "DOI": "10.1111/cts.12897", "article-title": "Risk of metformin in patients with type 2 diabetes with Covid-19: a preliminary retrospective report", "author": "Gao", "doi-asserted-by": "crossref", "journal-title": "Clin Transl Sci", "key": "10.1016/j.diabet.2020.101216_bib0175", "year": "2020" }, { "DOI": "10.1016/j.cmet.2020.04.021", "article-title": "Association of Blood Glucose control and outcomes in patients with Covid-19 and pre-existing type 2 diabetes", "author": "Zhu", "doi-asserted-by": "crossref", "first-page": "1068", "journal-title": "Cell Metab", "key": "10.1016/j.diabet.2020.101216_bib0180", "volume": "31", "year": "2020" }, { "DOI": "10.1016/j.diabet.2020.05.008", "article-title": "Prognostic factors in patients with diabetes hospitalized for COVID-19: findings from the CORONADO study and other recent reports", "author": "Scheen", "doi-asserted-by": "crossref", "first-page": "265", "journal-title": "Diabetes Metab", "key": "10.1016/j.diabet.2020.101216_bib0185", "volume": "46", "year": "2020" }, { "DOI": "10.7326/M16-1901", "article-title": "Clinical outcomes of metformin use in populations with chronic kidney disease, congestive heart failure, or chronic liver disease: a systematic review", "author": "Crowley", "doi-asserted-by": "crossref", "first-page": "191", "journal-title": "Ann Intern Med", "key": "10.1016/j.diabet.2020.101216_bib0190", "volume": "166", "year": "2017" }, { "DOI": "10.1001/archinternmed.2010.409", "article-title": "Metformin use and mortality among patients with diabetes and atherothrombosis", "author": "Roussel", "doi-asserted-by": "crossref", "first-page": "1892", "journal-title": "Arch Intern Med", "key": "10.1016/j.diabet.2020.101216_bib0195", "volume": "170", "year": "2010" } ], "reference-count": 39, "references-count": 39, "relation": {}, "score": 1, "short-container-title": [ "Diabetes & Metabolism" ], "short-title": [], "source": "Crossref", "subject": [ "Endocrinology", "General Medicine", "Endocrinology, Diabetes and Metabolism", "Internal Medicine" ], "subtitle": [], "title": [ "Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19" ], "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "47" }