Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

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The patients were ' 'screened after hospital admission from 10 March to 10 April 2020. We mainly focused on ' 'hospital discharge and death within 28\xa0days.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>We included 2796 participants: 63.7% men, mean age 69.7\u2009±\u2009' '13.2\xa0years, median BMI (25th–75th percentile) 28.4 (25.0–32.4) kg/m<jats:sup>2</jats:sup>. ' 'Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of ' 'participants, respectively. Within 28\xa0days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were ' 'discharged from hospital with a median duration of hospital stay of 9 (5–14) days, while 577 ' 'participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine ' 'metformin therapy and longer symptom duration on admission were positively associated with ' 'discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on ' 'admission, and higher aspartate aminotransferase, white cell count and C-reactive protein ' 'levels were associated with a reduced chance of discharge. Factors associated with death ' 'within 28\xa0days mirrored those associated with discharge, and also included routine ' 'treatment by insulin and statin as deleterious factors.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions/interpretation</jats:title>\n' ' <jats:p>In patients with diabetes hospitalised for COVID-19, we established ' 'prognostic factors for hospital discharge and death that could help clinicians in this ' 'pandemic period.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Trial registration</jats:title>\n' ' <jats:p><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ' 'ext-link-type="uri" xlink:href="http://clinicaltrials.gov">Clinicaltrials.gov</jats:ext-link> ' 'identifier: NCT04324736</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Graphical abstract</jats:title>\n' ' \n' ' </jats:sec>', 'DOI': '10.1007/s00125-020-05351-w', 'type': 'journal-article', 'created': {'date-parts': [[2021, 2, 19]], 'date-time': '2021-02-19T15:07:09Z', 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