Association of Metformin with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis

{ 'indexed': {'date-parts': [[2023, 3, 25]], 'date-time': '2023-03-25T00:41:07Z', 'timestamp': 1679704867854}, 'reference-count': 31, 'publisher': 'Georg Thieme Verlag KG', 'issue': '01', 'license': [ { 'start': { 'date-parts': [[2023, 2, 22]], 'date-time': '2023-02-22T00:00:00Z', 'timestamp': 1677024000000}, 'content-version': 'vor', 'delay-in-days': 52, 'URL': 'https://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2023, 1]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>Studies have demonstrated high prevalence of ' 'mortality in coronavirus disease (COVID-19) patients with type 2 diabetes mellitus; however, ' 'the effects of antidiabetic pharmacotherapy on COVID-19 complications need further ' 'exploration. The aim of the study was to explore the association of metformin use and ' 'mortality in COVID-19 patients. A literature search was conducted using the databases Medline ' '(via PubMed) and Cochrane Central Register of Controlled Trials until February 09, 2021. Nine ' 'studies were included in the meta-analysis, including 12,684 COVID-19 patients. The ' 'meta-analysis suggested 37% lower risk of mortality in patients receiving metformin (risk ' 'ratio: 0.63; 95% confidence interval: 0.50–0.78; p\u2009&lt;\u20090.001). However, no ' 'significant difference in hospitalization days between the two groups (p\u2009=\u20090.197) ' 'was observed. The analysis revealed significantly lower risk of having obesity (p\u2009' '&lt;\u20090.001), hypertension (p\u2009&lt;\u20090.001), heart failure (p\u2009&lt;\u2009' '0.001), and cerebrovascular disease (p\u2009=\u20090.015) in the group receiving metformin. ' 'The analysis also demonstrated significantly lower risk of using anticoagulants (p\u2009' '=\u20090.015), diuretics (p\u2009&lt;\u20090.001), and antiplatelets (p\u2009=\u20090.010) in ' 'patients receiving metformin. Our findings suggest that metformin use decreases mortality in ' 'COVID-19 patients. However, randomized studies demonstrating the consequences of metformin ' 'use are needed to understand the magnitude of the beneficial effects of metformin.</jats:p>', 'DOI': '10.1055/s-0042-1760353', 'type': 'journal-article', 'created': {'date-parts': [[2023, 2, 23]], 'date-time': '2023-02-23T00:00:45Z', 'timestamp': 1677110445000}, 'page': '013-020', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Association of Metformin with Mortality in COVID-19 Patients: A Systematic Review and ' 'Meta-Analysis', 'prefix': '10.1055', 'volume': '59', 'author': [ { 'given': 'Rizwana', 'family': 'Parveen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Centre for Translational and Clinical Research, School of ' 'Chemical & Life Sciences, Jamia Hamdard, New Delhi, India'}]}, { 'given': 'Pinki', 'family': 'Mishra', 'sequence': 'additional', 'affiliation': [ { 'name': 'Centre for Translational and Clinical Research, School of ' 'Chemical & Life Sciences, Jamia Hamdard, New Delhi, India'}]}, { 'given': 'Reva', 'family': 'Luthra', 'sequence': 'additional', 'affiliation': [ { 'name': 'Centre for Translational and Clinical Research, School of ' 'Chemical & Life Sciences, Jamia Hamdard, New Delhi, India'}]}, { 'ORCID': 'http://orcid.org/0000-0002-1227-2703', 'authenticated-orcid': False, 'given': 'Ram', 'family': 'Bajpai', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Medicine, Keele University, Staffordshire, United ' 'Kingdom'}]}, { 'ORCID': 'http://orcid.org/0000-0002-2509-3026', 'authenticated-orcid': False, 'given': 'Nidhi', 'family': 'Agarwal', 'sequence': 'additional', 'affiliation': [ { 'name': 'Centre for Translational and Clinical Research, School of ' 'Chemical & Life Sciences, Jamia Hamdard, New Delhi, India'}]}], 'member': '194', 'published-online': {'date-parts': [[2023, 2, 22]]}, 'reference': [ { 'key': 'ref1', 'doi-asserted-by': 'crossref', 'first-page': '108295', 'DOI': '10.1016/j.diabres.2020.108295', 'article-title': 'Association 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