Conv. Plasma
Nigella Sativa
Nitric Oxide
Peg.. Lambda

Home   COVID-19 treatment studies for Metformin  COVID-19 treatment studies for Metformin  C19 studies: Metformin  Metformin   Select treatmentSelect treatmentTreatmentsTreatments
Alkalinization Meta Lactoferrin Meta
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta Molnupiravir Meta
Cannabidiol Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta Nitric Oxide Meta
Ensovibep Meta Paxlovid Meta
Famotidine Meta Peg.. Lambda Meta
Favipiravir Meta Povidone-Iod.. Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Iota-carragee.. Meta
Ivermectin Meta Zinc Meta

Other Treatments Global Adoption
All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 37% Improvement Relative Risk Parveen et al. Metformin for COVID-19 META ANALYSIS Favors metformin Favors control

Association of Metformin with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis

Parveen et al., Annals of the National Academy of Medical Sciences (India), doi:10.1055/s-0042-1760353 (meta analysis)
Parveen et al., Association of Metformin with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis, Annals of the National Academy of Medical Sciences (India), doi:10.1055/s-0042-1760353 (meta analysis)
Jan 2023   Source   PDF  
  All Studies   Meta
Systematic review and meta analysis showing significantly lower mortality with metformin.
Currently there are 65 metformin studies and meta analysis shows:
Mortality32% lower [27‑37%]
Ventilation30% lower [11‑44%]
ICU admission17% lower [5‑28%]
Hospitalization18% lower [10‑24%]
Cases4% fewer [-6‑13%]
risk of death, 37.0% lower, RR 0.63, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Parveen et al., 31 Jan 2023, peer-reviewed, 5 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperMetforminAll
Association of Metformin with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis
Rizwana Parveen, Pinki Mishra, Reva Luthra, Ram Bajpai, PhD Nidhi Agarwal
Annals of the National Academy of Medical Sciences (India), doi:10.1055/s-0042-1760353
Studies have demonstrated high prevalence of mortality in coronavirus disease (COVID-19) patients with type 2 diabetes mellitus; however, the effects of antidiabetic pharmacotherapy on COVID-19 complications need further exploration. The aim of the study was to explore the association of metformin use and mortality in COVID-19 patients. A literature search was conducted using the databases Medline (via PubMed) and Cochrane Central Register of Controlled Trials until February 09, 2021. Nine studies were included in the meta-analysis, including 12,684 COVID-19 patients. The metaanalysis suggested 37% lower risk of mortality in patients receiving metformin (risk ratio: 0.63; 95% confidence interval: 0.50-0.78; p < 0.001). However, no significant difference in hospitalization days between the two groups (p ¼ 0.197) was observed. The analysis revealed significantly lower risk of having obesity (p < 0.001), hypertension (p < 0.001), heart failure (p < 0.001), and cerebrovascular disease (p ¼ 0.015) in the group receiving metformin. The analysis also demonstrated significantly lower risk of using anticoagulants (p ¼ 0.015), diuretics (p < 0.001), and antiplatelets (p ¼ 0.010) in patients receiving metformin. Our findings suggest that metformin use decreases mortality in COVID-19 patients. However, randomized studies demonstrating the consequences of metformin use are needed to understand the magnitude of the beneficial effects of metformin.
Conflict of Interest None declared.
Bailey, Gwilt, Diabetes, metformin and the clinical course of Covid-19: outcomes, mechanisms and suggestions on the therapeutic use of metformin, Front Pharmacol
Bramante, Ingraham, Murray, Observational study of metformin and risk of mortality in patients hospitalized with Covid-19, Lancet Healthy Longev
Cariou, Hadjadj, Wargny, Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study, Diabetologia
Chen, Wu, Chen, Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study, BMJ
Chen, Yang, Cheng, Clinical Characteristics and outcomes of patients with diabetes and COVID-19 in association with glucose-lowering medication, Diabetes Care
Cheng, Liu, Li, Metformin is associated with higher incidence of acidosis, but not mortality, in individuals with COVID-19 and pre-existing type 2 diabetes, Cell Metab
Crouse, Grimes, Li, Might, Ovalle et al., Metformin use is associated with reduced mortality in a diverse population with COVID-19 and diabetes, Front Endocrinol
Crouse, Grimes, Li, Might, Ovalle et al., Metformin use is associated with reduced mortality in a diverse population with Covid-19 and diabetes, Front Endocrinol
Dalton, Bolen, Mascha, Publication bias: the elephant in the review, Anesth Analg
Davis, Xie, Viollet, Zou, Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase, Diabetes
Esam, A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19, Diabetes Res Clin Pract
Gao, Liu, Zhong, Risk of metformin in patients with type 2 diabetes with COVID-19: a preliminary retrospective report, Clin Transl Sci
Hariyanto, Kurniawan, Metformin use is associated with reduced mortality rate from coronavirus disease 2019 (COVID-19) infection, Obes Med
Hattori, Suzuki, Hattori, Kasai, Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells, Hypertension
Higgins, Green, Quality Assessment of Systematic Reviews and Meta-analysis
Jiang, Chen, Yin, Association of metformin with mortality or ARDS in patients with COVID-19 and type 2 diabetes: a retrospective cohort study, Diabetes Res Clin Pract
Kow, Hasan, Mortality risk with preadmission metformin use in patients with COVID-19 and diabetes: a meta-analysis, J Med Virol
Kow, Ramachandram, Hasan, Metformin in COVID-19: clinical trials are needed to prove its benefits, Ir J Med Sci
Lalau, Al-Salameh, Hadjadj, Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19, Diabetes Metab
Lally, Tsoukas, Halladay, Neill, Gravenstein et al., Metformin is associated with decreased 30-day mortality among nursing home residents infected with SARS-CoV2, J Am Med Dir Assoc
Li, Wei, Li, Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19, Endocr Pract
Li, Wei, Li, Metformin use in diabetes prior to hospitalization: effects on mortality in Covid-19, Endocr Pract
Lui, Tan, Is metformin a miracle or a menace in COVID-19 patients with type 2 diabetes?, J Diabetes Investig
Luo, Qiu, Liu, Metformin treatment was associated with decreased mortality in COVID-19 patients with diabetes in a retrospective analysis, Am J Trop Med Hyg
Mclachlan, The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms, Clin Hypertens
Moher, Liberati, Tetzlaff, Altman, Group, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med
Parveen, Sehar, Bajpai, Agarwal, Association of diabetes and hypertension with disease severity in covid-19 patients: a systematic literature review and exploratory meta-analysis, Diabetes Res Clin Pract
Pérez-Belmonte, Torres-Peña, Carmona, Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study, BMC Med
Stroup, Berlin, Morton, Meta-analysis of observational studies in epidemiology: a proposal for reporting. Metaanalysis Of Observational Studies in Epidemiology (MOOSE) group, JAMA
Wong, Lui, Lui, Metformin use in relation to clinical outcomes and hyperinflammatory syndrome among COVID-19 patients with type 2 diabetes: a propensity score analysis of a territory-wide cohort, Front Endocrinol
Zhou, Yu, Du, Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop