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0 0.5 1 1.5 2+ Mortality 10% Improvement Relative Risk Death/hospitalization 8% c19early.org/mf Ouchi et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Antidiabetic treatment and COVID-19 Outcomes: A population-based cohort study in primary health care in Catalonia during the first wave of the pandemic
Ouchi et al., Primary Care Diabetes, doi:10.1016/j.pcd.2022.10.001
4 Oct 2022    Source   PDF   Share   Tweet
Retrospective 31,006 diabetic COVID-19 patients in Spain, showing lower mortality with metformin treatment, without statistical significance. Authors provide results for metformin compared with untreated patients rather than all non-metformin patients, which may increase confounding due to higher prevalence for treatment of patients with more severe disease.
risk of death, 9.9% lower, OR 0.90, p = 0.19, treatment 6,168, control 9,875, inverted to make OR<1 favor treatment, metformin monotherapy vs. untreated, RR approximated with OR.
risk of death/hospitalization, 8.3% lower, OR 0.92, p = 0.12, treatment 6,168, control 9,875, inverted to make OR<1 favor treatment, metformin monotherapy vs. untreated, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ouchi et al., 4 Oct 2022, retrospective, Spain, peer-reviewed, mean age 71.5, 5 authors, study period March 2020 - June 2020.
Contact: mginer@idiapjgol.info.
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