Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine in Colombia

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2024, 3, 3]], 'date-time': '2024-03-03T14:27:54Z', 'timestamp': 1709476074943}, 'posted': {'date-parts': [[2020, 10, 23]]}, 'group-title': 'In Review', 'reference-count': 0, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2020, 10, 23]], 'date-time': '2020-10-23T00:00:00Z', 'timestamp': 1603411200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2020, 10, 19]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p><jats:bold>Background:</jats:bold> To date, there is no specific antiviral ' 'therapy for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that causes ' 'Coronavirus disease 2019 (Covid-19). Since there is no specific therapy against SARS-CoV2, ' 'current efforts aim to prevent contagion through public health measures and develop a ' 'protective vaccine. While waiting for the latter, it is necessary to evaluate the drugs that ' 'at least, in initial studies, suggested some degree of utility in the management of Covid-19 ' 'or its complications.The Objective of the study was to describe the clinical manifestations ' 'and outcomes of patients with severe Covid-19 Pneumonia treated with corticosteroids and ' 'colchicine.<jats:bold>Materials and Methods:<jats:italic> </jats:italic></jats:bold>A cross ' 'sectional study of 301 adult patients with Covid-19 Pneumonia confirmed by Real-Time ' 'Polymerase Chain Reaction for SARS-CoV2 (RT-PCR SARS-CoV2), Berlin protocol, who required ' 'hospitalization in three hospitals in Antioquia, Colombia. Patients were treated according to ' 'the institutional protocol (from March 20, 2020 to June 30, 2020) with corticosteroid if the ' 'patient required supplemental oxygen. From July 1, 2020, the management protocol changed with ' 'the addition of colchicine to all patients admitted to the institutions. The treatment was ' 'supervised and monitored by the same specialist in infectology of the institutions. We ' 'describe the clinical manifestations and outcomes of the patients who received these ' 'treatments. The patient’s information was analyzed according to the outcome of interest ' '(alive/dead) with univariate, bivariate, and multivariate measures to adjust the variables ' 'that presented statistical association.<jats:bold>Results:<jats:italic> ' '</jats:italic></jats:bold>All patients had pneumonia documented by chest computed tomography ' 'with ground glass images and presented an alveolar pressure / inspired oxygen fraction (PaFi) ' 'less than 300. 240 (79.7%) of patients received corticosteroids, and 145 (48.2%) also ' 'received colchicine; of these, 14 (9.6%) died vs. 23 (14.7%) of those who did not receive it. ' 'Hospital mortality due to severe Covid-19 Pneumonia was 12.3% in three hospitals in ' 'Colombia.<jats:bold>Conclusions:<jats:italic> </jats:italic></jats:bold>Treatment with ' 'corticosteroids and colchicine for managing patients with severe Covid-19 pneumonia was ' 'associated with low mortality at the hospital level. Randomized, placebo-controlled studies ' 'are required to evaluate the effect of corticosteroids and colchicine on complications or ' 'death from Covid-19.</jats:p>', 'DOI': '10.21203/rs.3.rs-94922/v1', 'type': 'posted-content', 'created': { 'date-parts': [[2020, 10, 23]], 'date-time': '2020-10-23T14:02:27Z', 'timestamp': 1603461747000}, 'source': 'Crossref', 'is-referenced-by-count': 7, 'title': 'Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine ' 'in Colombia', 'prefix': '10.21203', 'author': [ { 'given': 'Miguel Alejandro', 'family': 'Pinzón', 'sequence': 'first', 'affiliation': [{'name': 'Clinica Medellin'}]}, { 'given': 'Doris Cardona', 'family': 'Arango', 'sequence': 'additional', 'affiliation': [{'name': 'Universidad CES'}]}, { 'given': 'Juan Felipe', 'family': 'Betancur', 'sequence': 'additional', 'affiliation': [{'name': 'Clínica Medellín'}]}, { 'given': 'Héctor', 'family': 'Holguín', 'sequence': 'additional', 'affiliation': [{'name': 'Clinica Medellin'}]}, { 'given': 'Carolina Arias', 'family': 'Arias', 'sequence': 'additional', 'affiliation': [{'name': 'Universidad CES'}]}, { 'given': 'Bernardo Javier', 'family': 'Muñoz', 'sequence': 'additional', 'affiliation': [{'name': 'Clínica Medellín'}]}, { 'given': 'Michael', 'family': 'Amarillo', 'sequence': 'additional', 'affiliation': [{'name': 'Clinica Medellin'}]}, { 'given': 'Juan Felipe', 'family': 'Llano', 'sequence': 'additional', 'affiliation': [{'name': 'Clínica Medellín'}]}, { 'given': 'Pablo', 'family': 'Montoya', 'sequence': 'additional', 'affiliation': [{'name': 'Clinica Medellin'}]}], 'member': '8761', 'container-title': [], 'original-title': [], 'link': [ { 'URL': 'https://www.researchsquare.com/article/rs-94922/v1', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://www.researchsquare.com/article/rs-94922/v1.html', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 7, 29]], 'date-time': '2022-07-29T00:00:29Z', 'timestamp': 1659052829000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.researchsquare.com/article/rs-94922/v1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2020, 10, 23]]}, 'references-count': 0, 'URL': 'http://dx.doi.org/10.21203/rs.3.rs-94922/v1', 'relation': { 'is-preprint-of': [ { 'id-type': 'doi', 'id': '10.1186/s12941-021-00460-9', 'asserted-by': 'subject'}]}, 'published': {'date-parts': [[2020, 10, 23]]}, 'subtype': 'preprint'}