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0 0.5 1 1.5 2+ Mortality 57% Improvement Relative Risk Colchicine  García-Posada et al.  LATE TREATMENT Is late treatment with colchicine + combined treatments beneficial for COVID-19? Retrospective 209 patients in Colombia Lower mortality with colchicine + combined treatments (p=0.014) c19early.org García-Posada et al., J. Infection and.., Mar 2021 Favors colchicine Favors control

Clinical outcomes of patients hospitalized for COVID-19 and evidence-based on the pharmacological management reduce mortality in a region of the Colombian Caribbean

García-Posada et al., Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.02.013
Mar 2021  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.0000001 from 54 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 209 hospitalized patients in Colombia, showing lower mortality with antibiotics + LMWH + corticosteroids + colchicine in multivariable analysis.
risk of death, 56.9% lower, RR 0.43, p = 0.01, treatment 48 of 99 (48.5%), control 59 of 110 (53.6%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
García-Posada et al., 6 Mar 2021, retrospective, Colombia, peer-reviewed, 8 authors, dosage not specified, this trial uses multiple treatments in the treatment arm (combined with antibiotics, LMWH, and corticosteroidsPERIOD:5/20-8/20) - results of individual treatments may vary.
This PaperColchicineAll
Clinical outcomes of patients hospitalized for COVID-19 and evidence-based on the pharmacological management reduce mortality in a region of the Colombian Caribbean
Mara García-Posada, Sandra Aruachan-Vesga, Danis Mestra, Katherine Humánez, Héctor Serrano-Coll, Heriberto Cabrales, Álvaro Faccini, Salim Mattar
Journal of Infection and Public Health, doi:10.1016/j.jiph.2021.02.013
Introduction: Despite the high volume of infections, some clinical aspects of this disease are still unknown. There are currently no studies in Colombia that describe the disease's clinical and treatment aspects in detail. Objective: Describe the characteristics and clinical management of a group of admitted patients with SARS-CoV-2 infection in a private clinic in Montería, Córdoba-Colombia. Patients and methods: A descriptive observational study was carried out between May and August 2020 in 209 hospitalized patients with a confirmed diagnosis of COVID-19. Upon admittance, clinical, sociodemographic characteristics, comorbidities, and complications were analyzed. Additionally, the effect of the following medications was described: 1-antibiotics (cefepime, piperacillin, tazobactam, meropenem, vancomycin) + low molecular weight heparin (LMWH) + corticosteroids (dexamethasone-methylprednisolone) + colchicine. 2-Antibiotic + LMWH + corticosteroids. 3-LMWH + corticosteroids. 4-LMWH + corticosteroids + colchicine. 5-Other treatments (Tocilizumab). Results: 107 (51%) of the 209 patients with a confirmed diagnosis of COVID-19 passed away. The main comorbidities related to mortality of these hospitalized patients with COVID-19 were obesity and kidney disease (P < 0.05). The main complications associated with fatal outcomes in this group of patients were Acute Respiratory Distress Syndrome (ARDS) and sepsis (P < 0.05). Furthermore, it was evidenced that the colchicine combination showed a significant difference in reducing mortality in hospitalized patients compared to the other therapeutic regimens (P < 0.05). Conclusion: A mortality rate of 51% was found attributable to several factors such as advanced age, obesity, kidney disease, and an average time in days of late consultation. The implementation of the colchicine combination could reduce the mortality rate in this disease.
Competing interests None declared. Ethical approval This research was approved by the ethics and research committee of Oncomedica S.A.
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'10.1007/s11239-020-02162-z', 'article-title': 'The association between treatment with heparin and survival in patients ' 'with Covid-19', 'author': 'Ayerbe', 'doi-asserted-by': 'crossref', 'first-page': '298', 'issue': 'August (2)', 'journal-title': 'J Thromb Thrombolysis', 'key': '10.1016/j.jiph.2021.02.013_bib0220', 'volume': '50', 'year': '2020'}, { 'DOI': '10.1111/jth.14817', 'article-title': 'Anticoagulant treatment is associated with decreased mortality in ' 'severe coronavirus disease 2019 patients with coagulopathy', 'author': 'Tang', 'doi-asserted-by': 'crossref', 'first-page': '1094', 'issue': 'May (5)', 'journal-title': 'J Thromb Haemost', 'key': '10.1016/j.jiph.2021.02.013_bib0225', 'volume': '18', 'year': '2020'}], 'reference-count': 45, 'references-count': 45, 'relation': {}, 'score': 1, 'short-container-title': ['Journal of Infection and Public Health'], 'short-title': [], 'source': 'Crossref', 'subject': [ 'Infectious Diseases', 'Public Health, Environmental and 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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