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0 0.5 1 1.5 2+ Mortality 32% Improvement Relative Risk Colchicine for COVID-19  Danjuma et al.  META ANALYSIS Favors colchicine Favors control

Does Colchicine Reduce Mortality in Patients with Covid-19 Clinical Syndrome? An Umbrella Review of Published Meta-Analyses

Danjuma et al., Elsevier BV, doi:10.2139/ssrn.4447127, PROSPERO CRD42023397246
May 2023  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
*, now known with p = 0.0000001 from 54 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Umbrella review of 18 colchicine meta analyses, showing significantly lower COVID-19 mortality with colchicine.
10 meta analyses show significant improvements with colchicine for mortality Danjuma, Elshafei, Elshiwy, Golpour, Lien, Rai, Salah, Zein, oxygen therapy Elshiwy, hospitalization Kow, and severity Yasmin.
Currently there are 54 colchicine for COVID-19 studies, showing 29% lower mortality [19‑39%], 29% lower ventilation [-15‑56%], 34% lower ICU admission [8‑52%], 19% lower hospitalization [11‑26%], and 9% more cases [-8‑29%].
risk of death, 32.0% lower, OR 0.68, p < 0.001, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Danjuma et al., 17 May 2023, preprint, 7 authors, trial PROSPERO CRD42023397246. Contact:,
This PaperColchicineAll
Does colchicine reduce mortality in patients with COVID-19 clinical syndrome? an umbrella review of published meta-analyses
Mohammed I Danjuma, Rana Sayed, Maryam Aboughalia, Aseel Hassona, Basant Selim Elsayed, Mohamed Elshafei, Abdelnaser Elzouki, Dr Mohammed Ibn-Mas'ud Danjuma, New York, Doha Qatar
Background Despite significant improvements in both treatment and prevention strategies, as well as multiple commissioned reviews, there remains uncertainty regarding the survival benefit of repurposed drugs such as colchicine in patients with Covid-19 clinical syndrome. Methods: In this umbrella review, we carried out a comprehensive search of PubMed, EMBASE, Cochrane Database of Systematic Reviews, Science Citation Index, and the Database of Abstracts of Reviews of Effectiveness between 1st January 2020 and 31st January 2023 for systematic reviews and meta-analyses evaluating the mortality-reducing benefits of colchicine in patients with Covid-19. This was to ascertain the exact relationship between colchicine exposure and mortality outcomes in these cohorts of patients. We utilized A Measurement Tool to Assess systematic Reviews-2 (AMSTAR-2) to conduct an exhaustive methodological quality and risk of bias assessment of the included reviews. Results: We included eighteen meta-analyses (n = 199,932 participants) in this umbrella review. Colchicine exposure was associated with an overall reduction of about 35% in the risk of mortality (odds ratio 0.68, confidence interval [CI] 0.58-0.78; I2 = 94%, p = 0.001). Further examination of pooled estimates of mortality outcomes by the quality effects model (corrected for the methodological quality and risk of bias of the constituent reviews) reported similar point estimates (OR 0.73; CI 0.59 to 0.91; I2 = 94%). Conclusion: In a pooled umbrella evaluation of published meta-analyses of Covid-19 patient cohorts, exposure to colchicine was associated with a reduction in overall mortality. Although it remains uncertain if this effect could potentially be attenuated or augmented by Covid-19 vaccination.
Not applicable Included Records excluded (n = 67) Wrong outcome (30) Wrong study design (15) Wrong population (22) Records screened (n = 106) Full This preprint research paper has not been peer reviewed. Electronic copy available at: P r e p r i n t n o t p e e r r e v i e w e d
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