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Clinical course of Covid-19 in a cohort of patients with Behçet disease

Correa-Rodríguez et al., Medicina Clínica (English Edition), doi:10.1016/j.medcle.2022.08.009
Sep 2022  
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Oxygen therapy -150% Improvement Relative Risk Hospitalization -150% Recovery 7% Case 1% Colchicine  Correa-Rodríguez et al.  Prophylaxis Is prophylaxis with colchicine beneficial for COVID-19? Retrospective 244 patients in Spain Study underpowered for serious outcomes c19early.org Correa-Rodríguez et al., Medicina Clín.., Sep 2022 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
 
*, now with p = 0.00000031 from 56 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Retrospective 244 Behçet disease patients in Spain, showing no significant difference in outcomes with colchicine treatment. Confounding by indication may significantly affect results - colchicine may be prescribed more often for more serious cases, which may have a higher baseline risk for COVID-19.
risk of oxygen therapy, 149.7% higher, RR 2.50, p = 1.00, treatment 1 of 163 (0.6%), control 0 of 81 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of hospitalization, 149.7% higher, RR 2.50, p = 1.00, treatment 1 of 163 (0.6%), control 0 of 81 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of no recovery, 7.1% lower, RR 0.93, p = 1.00, treatment 13 of 24 (54.2%), control 7 of 12 (58.3%), NNT 24, full recovery at 6 months.
risk of case, 0.6% lower, RR 0.99, p = 1.00, treatment 24 of 163 (14.7%), control 12 of 81 (14.8%), NNT 1100.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Correa-Rodríguez et al., 19 Sep 2022, retrospective, Spain, peer-reviewed, mean age 44.0, 6 authors. Contact: macoro@ugr.es.
This PaperColchicineAll
Clinical course of Covid-19 in a cohort of patients with Behçet disease
María Correa-Rodríguez, José-Luis Callejas-Rubio, Blanca Rueda-Medina, Raquel Ríos-Fernández, Javier De La Hera-Fernández, Norberto Ortego-Centeno
Medicina Clínica, doi:10.1016/j.medcli.2021.11.009
Objective: The implications of Covid-19 in patients with Behc ¸ et's disease (BD) are unknown. Patients with BD usually take long-term therapy with therapeutic agents that have been tested in Covid-19 patients. We aimed to assess the prevalence of Covid-19 in a cohort of patients with BD and investigate whether those patients with a long-term treatment with colchicine, tumor necrosis factor inhibitors (TNFi) or glucocorticoids are at reduced or increased prevalence of Covid-19 related clinical outcomes. Methods: A retrospective study was conducted among 244 patients with BD (86.1% females; mean age 43.95 ± 11.11 years). Each participant completed an online questionnaire regarding demographics, medical conditions, dispensed colchicine, TNFi or oral glucocorticoids, Covid-19 infection, clinical symptoms and recovery. Results: The prevalence of Covid-19 infection was 14.75%. Regarding dose of colchicine, the presence of ageusia was lower in patients taking 0.5 mg/day of colchicine compared to those taking 1.5 mg/day (p = 0.021). The prevalence of dyspnea was significantly higher in patients taking TNFi compared with those without therapy (p = 0.032). With regards to oral glucocorticoids, no significant differences were found. Conclusions: The prevalence of Covid-19 among patients with BD seems to be higher than that among the general population in Spain. Continuous TNFi therapy might increase the prevalence of worse clinical outcomes such as dyspnea; oral glucocorticoids and colchicine apparently provided no protection against the Covid-19 related clinical outcomes of patients with BD.
Authors' contributions Conceptualization, MCR, JLCR and NORC; Data curation, BRM, RFR and JHF; Formal analysis, MCR and NOC; Methodology, MCR, BRM, NOC; Project administration, MCR and JFH; Supervision, JLCR and NOC; Validation, BRM and RRF; Visualization, BRM and JHF; Writing -original draft, MCR; Writing -review & editing, BRM and NOC. All authors read and approved the final manuscript. Ethical conduct of research All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Written informed consent was obtained for all participants. Conflicts of interest The authors declare no conflict of interest. Appendix
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