Abstract: Journal Pre-proof Randomized controlled trial of colchicine add on to the standard therapy in moderate and severe corona virus Disease-19 infection Faiq I. Gorial, Mohammed Fauzi Maulood, Ahmed S. Abdulamir, Ahmed Sameer Alnuaimi, Manal K. abdulrrazaq, Fadil Agla Bonyan PII: S2049-0801(22)00353-3 DOI: https://doi.org/10.1016/j.amsu.2022.103593 Reference: AMSU 103593 To appear in: Annals of Medicine and Surgery Received Date: 18 February 2022 Revised Date: 1 April 2022 Accepted Date: 2 April 2022 Please cite this article as: Gorial FI, Maulood MF, Abdulamir AS, Alnuaimi AS, abdulrrazaq MK, Bonyan FA, Randomized controlled trial of colchicine add on to the standard therapy in moderate and severe corona virus Disease-19 infection, Annals of Medicine and Surgery (2022), doi: https://doi.org/10.1016/ j.amsu.2022.103593. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. 1 A Randomized Controlled Trial of Colchicine add on to the Standard Therapy in Moderate and Severe Corona Virus Disease-19 Infection Faiq I. Gorial 1, Mohammed Fauzi Maulood2 , , Ahmed S. Abdulamir 3 , Ahmed Sameer Alnuaimi 4, Manal K. abdulrrazaq 5, Fadil Agla Bonyan 6 ro of 1, 5 College of Medicine, University of Baghdad, Bab Al-Muadham, Baghdad, Iraq 2 Alkarkh Hospital, Alatefiya, Baghdad, Iraq 3 College of Medicine, Alnahrain University, Alkadymia, Baghdad, Iraq 4 Primary Health Care Corporation, Department Of Clinical Research, Aldoha, Qatar 6 Emergency physician, Director of EMS of Iraq, Emergency medical department, Baghdad Teaching Hospital Corresponding author email: faiqig@gmail.com Jo ur na lP re -p Running title: Colchicine as Add-on Therapy to the Standard of Care Measures in COVID-19 Therapy Table 1: Baseline characteristics of the study groups. Study groups Intervention (Colchicine add on) + moderate Control + Severe Control + disease disease moderate disease N % N % N % Intervention (Colchicine add on) + Severe disease N % Age group (years) 18-39 40-59 60+ Total 8 14 18 40 20.0 35.0 45.0 100.0 Smoking habit Non-smoker Current smoker Ex-smoker Total 25 10 5 40 62.5 25.0 12.5 100.0 Comorbidities Hypertension Diabetes Mellitus Ischemic Heart Disease Asthma Cancer Stroke Others Any..