Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19: a pragmatic, open-label randomized trial
H G Gaitán-Duarte, C Álvarez-Moreno, C J Rincón-Rodríguez, N Yomayusa-González, J A Cortés, MD PhD J C Villar, MD J S Bravo-Ojeda, MD MSc A García-Peña, PhD W Adarme-Jaimes, PhD V A Rodríguez-Romero, MSc S L Villate-Soto, MD PhD G Buitrago, J Chacón-Sarmiento, MSc M Macias-Quintero, MSc C P Vaca, C Gómez-Restrepo, N Rodríguez-Malagón
eClinicalMedicine, doi:10.1016/j.eclinm.2021.101242
Background The use of rosuvastatin plus colchicine and emtricitabine/tenofovir in hospitalized patients with SARS-CoV-2 disease (COVID-19) has not been assessed. The objective of this study was to assess the effectiveness and safety of rosuvastatin plus colchicine, emtricitabine/tenofovir, and their combined use in these patients. Methods This was a randomized, controlled, open-label, multicentre, parallel, pragmatic study conducted in six referral hospitals in Bogot a, Colombia. The study enrolled hospitalized patients over 18 years of age with a confirmed diagnosis of COVID-19 complicated with pneumonia, not on chronic treatment with the study medications, and with no contraindications for their use. Patients were assigned 1:1:1:1. 1) emtricitabine with tenofovir disoproxil fumarate (FTC/TDF, 200/300 mg given orally for 10 days); 2) colchicine plus rosuvastatin (COLCH+ROSU, 0.5 mg and 40 mg given orally for 14 days); 3) emtricitabine with tenofovir disoproxil plus colchicine and rosuvastatin at the same doses and for the same period of time (FTC/TDF+COLCH+ROSU); or 4) the Colombian consensus standard of care, including a corticosteroid (SOC). The primary endpoint was 28-day all-cause mortality. A modified intention-to-treat analysis was used together with a usefulness analysis to determine which could be the best treatment. The trial was registered at ClinicalTrials.gov: NCT04359095
Author's contributions Hernando G. Gait an-Duarte: leader researcher, design, contact with external entities, data collection, analysis and interpretation, funding, writing; Carlos Alvarez-Moreno: design, data collection, analysis and interpretation; Carlos Javier Rincon: design, analysis and interpretation, writing; Nancy Yomayusa-Gonz alez: data collection, analysis and interpretation, writing; Jorge Alberto Cort es: data collection, analysis and interpretation, writing; Juan Carlos Villar: design, data collection; Juan Sebasti an Bravo-Ojeda: data collection; Angel Garc ıa-Peña: design, data collection; Wilson Adarme-Jaimes: design, data collection; Viviana Rodr ıguez-Romero: design, analysis and interpretation; Steffany L Villate-Soto: supervisory role; Giancarlo Buitrago: design, data analysis and interpretation, writing; Julio Chac on-Sarmiento: data collection; Mart ın Mac ıas-Quintero: data analysis; Claudia Patricia Vaca: analysis and interpretation; Carlos G omez-Restrepo: analysis and interpretation; Nelcy Rodr ıguez-Malag on: design, data collection, analysis and interpretation.
Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j. eclinm.2021.101242.
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