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0 0.5 1 1.5 2+ Mortality 70% Improvement Relative Risk Death/hospitalization -30% Death/hospitalization (b) 22% Recovery -6% c19early.org/o Dorward et al. Colchicine for COVID-19 RCT LATE TREATMENT Is late treatment with colchicine beneficial for COVID-19? RCT 1,301 patients in the United Kingdom (March - May 2021) Lower mortality with colchicine (not stat. sig., p=0.43) Dorward et al., British J. General Practice, doi:10.3399/BJGP.2022.0083 Favors colchicine Favors control
Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
Dorward et al., British Journal of General Practice, doi:10.3399/BJGP.2022.0083 (date from earlier preprint)
Dorward et al., Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial, British Journal of General Practice, doi:10.3399/BJGP.2022.0083 (date from earlier preprint)
Sep 2021   Source   PDF  
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Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580.
risk of death, 69.7% lower, RR 0.30, p = 0.43, treatment 0 of 156 (0.0%), control 1 of 120 (0.8%), NNT 120, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of death/hospitalization, 29.8% higher, RR 1.30, p = 0.66, treatment 6 of 156 (3.8%), control 4 of 133 (3.0%), odds ratio converted to relative risk, concurrent randomisation.
risk of death/hospitalization, 22.1% lower, RR 0.78, p = 0.59, treatment 6 of 156 (3.8%), control 119 of 1,145 (10.4%), odds ratio converted to relative risk, including control patients before the colchicine arm started.
risk of no recovery, 6.4% higher, HR 1.06, p = 0.67, treatment 156, control 133, inverted to make HR<1 favor treatment, time to alleviation of symptoms, concurrent randomisation.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dorward et al., 23 Sep 2021, Randomized Controlled Trial, United Kingdom, peer-reviewed, 21 authors, study period 4 March, 2021 - 26 May, 2021, average treatment delay 6.0 days, dosage 0.5mg days 1-14.
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Abstract: Accepted Manuscript British Journal of General Practice Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial Dorward, Jienchi; Yu, Ly-mee; Hayward, Gail; Saville, Benjamin; Gbinigie, Oghenekome; van Hecke, Oliver; Ogburn, Emma; Evans, Philip; Thomas, Nicholas; Patel, Mahendra; Richards, Duncan; Berry, Nicholas ; Detry, Michelle; Saunders, Christina; Fitzgerald, Mark; Harris, Victoria; Shanyinde, Milensu; de Lusignan, Simon; Andersson, Monique; Butler, Christopher; Hobbs, FD Richard DOI: https://doi.org/10.3399/BJGP.2022.0083 To access the most recent version of this article, please click the DOI URL in the line above. Received 11 February 2022 Revised 25 February 2022 Accepted 02 March 2022 © 2022 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/). Published by British Journal of General Practice. For editorial process and policies, see: https://bjgp.org/authors/bjgp-editorial-process-and-policies When citing this article please include the DOI provided above. Author Accepted Manuscript This is an ‘author accepted manuscript’: a manuscript that has been accepted for publication in British Journal of ­General Practice, but which has not yet undergone subediting, typesetting, or correction. Errors discovered and corrected during this process may materially alter the content of this manuscript, and the latest published version (the Version of Record) should be used in preference to any preceding versions Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial PRINCIPLE Trial Collaborative Group¶ ¶Writing committee listed below on behalf of the PRINCIPLE Trial Collaborative Group. PRINCIPLE trial collaborators are listed in the appendix Writing committee Dr Jienchi Dorward (0000-0001-6072-1430)*1,2 clinical research fellow, Prof Ly-Mee Yu (00000003-0331-7364)*1 associate professor, Prof Gail Hayward (0000-0003-0852-627X)1 associate professor, Dr Benjamin R Saville3,4 statistician, Dr Oghenekome Gbinigie (0000-0002-29634491)1 clinical research fellow, Dr Oliver Van Hecke (0000-0002-6229-5057)1 academic clinical lecturer, Dr Emma Ogburn (0000-0001-7643-572X)1 director of operations, Prof Philip H Evans (0000-0002-5277-3545)5,6 associate professor, Dr Nicholas PB Thomas (0000-0003-04606870)6,7 general practitioner, Prof Mahendra G Patel (0000-0001-6703-3542)1 professor, Prof Duncan Richards (0000-0002-8093-7084)8 professor, Dr Nicholas Berry (0000-0001-87013258)3 statistician, Dr Michelle A Detry (0000-0002-2794-1439)3 statistician, Dr Christina Saunders (0000-0003-4325-9568)3 statistician, Dr Mark Fitzgerald (0000-0002-8912-1663)3 statistician, Dr Victoria Harris (0000-0002-3345-2826)1 statistician, Dr Milensu Shanyinde (0000-0003-4842-9247)1 statistician, Prof Simon de Lusignan (0000-0002-8553-2641)1,7 professor, Dr Monique I Andersson (0000-0003-0619-1074)9 consultant, Prof Christopher C Butler professor (0000-0002-0102-3453), 1†Prof FD Richard Hobbs (0000-0001-7976-7172) 1† professor 1 Writing Committee affiliations 1. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK 2. Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu–Natal, Durban, South Africa 3. Berry Consultants, Texas, USA 4. Department of Biostatistics, Vanderbilt University School of..
Late treatment
is less effective
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