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All Studies   Meta Analysis       

Edoxaban and/or colchicine for patients with coronavirus disease 2019 managed in the out-of-hospital setting (CONVINCE): a randomized clinical trial

Landi et al., Journal of Cardiovascular Medicine, doi:10.2459/JCM.0000000000001639, CONVINCE, NCT04516941
May 2024  
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Hospitalization -4% Improvement Relative Risk Oxygen therapy -5% Analgesic need 40% Viral clearance 11% Colchicine  CONVINCE  LATE TREATMENT  RCT Is late treatment with colchicine beneficial for COVID-19? RCT 59 patients in multiple countries No significant difference in outcomes seen c19early.org Landi et al., J. Cardiovascular Medicine, May 2024 Favorscolchicine Favorscontrol 0 0.5 1 1.5 2+
Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020, now with p = 0.00000031 from 56 studies.
Lower risk for mortality, ICU, hospitalization, and recovery.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 111 treatments. c19early.org
Early terminated RCT with 14 colchicine, 13 edoxaban, 16 colchicine+edoxaban, and 16 control patients, showing no significant difference in outcomes with treatment up to 7 days after PCR diagnosis.
risk of hospitalization, 4.0% higher, RR 1.04, p = 0.98, treatment 30, control 29.
risk of oxygen therapy, 5.0% higher, RR 1.05, p = 0.97, treatment 30, control 29.
risk of analgesic need, 40.0% lower, RR 0.60, p = 0.97, treatment 30, control 29.
risk of no viral clearance, 11.0% lower, RR 0.89, p = 0.77, treatment 30, control 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Landi et al., 28 May 2024, Randomized Controlled Trial, multiple countries, peer-reviewed, 11 authors, trial NCT04516941 (history) (CONVINCE).
This PaperColchicineAll
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Late treatment
is less effective
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