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0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk Colchicine  Rodriguez-Nava et al.  LATE TREATMENT Is late treatment with colchicine beneficial for COVID-19? Retrospective 313 patients in the USA No significant difference in mortality Rodriguez-Nava et al., Mayo Clinic Pro.., Nov 2020 Favors colchicine Favors control

Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study

Rodriguez-Nava et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Nov 2020  
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Colchicine for COVID-19
5th treatment shown to reduce risk in September 2020
*, now known with p = 0.00000018 from 53 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 313 patients, mostly critical stage and mostly requiring respiratory support. Confounding by indication likely.
This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely; excessive unadjusted differences between groups; unadjusted results with no group details.
Study covers colchicine and HCQ.
risk of death, 5.5% lower, RR 0.94, p = 0.87, treatment 16 of 52 (30.8%), control 85 of 261 (32.6%), NNT 56, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rodriguez-Nava et al., 5 Nov 2020, retrospective, USA, peer-reviewed, median age 68.0, 8 authors, dosage not specified.
This PaperColchicineAll
Clinical Characteristics and Risk Factors for Death of Hospitalized Patients With COVID-19 in a Community Hospital: A Retrospective Cohort Study
MD Guillermo Rodriguez-Nava, MD; Daniela Maria Adriana Yanez-Bello, Daniela Patricia Trelles-Garcia, Chul Won Chung, MD Sana Chaudry, MD Aimen S Khan, MD, FACP Harvey J Friedman, MD David W Hines
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, doi:10.1016/j.mayocpiqo.2020.10.007
Objective: To describe the clinical characteristics, outcomes, and risk factors for death of patients with coronavirus disease 2019 (COVID-19) in a community hospital setting. Patients and Methods: This single-center retrospective cohort study included 313 adult patients with laboratory-confirmed COVID-19 admitted to a community hospital in Cook County, Illinois, from March 1, 2020, to May 25, 2020. Demographics, medical history, underlying comorbidities, symptoms, signs, laboratory findings, imaging studies, management, and progression to discharge or death data were collected and analyzed. Results: Of 313 patients, the median age was 68 years (interquartile range, 59.0-78.5 years; range, 19-98 years), 182 (58.1%) were male, 119 (38%) were white, and 194 (62%) were admitted from a long-term care facility (LTCF). As of May 25, 2020, there were 212 (67.7%) survivors identified, whereas 101 (32.3%) nonsurvivors were identified. Multivariable Cox regression analysis showed increasing hazards of inpatient death associated with older age (hazard ratio [HR] 1.02; 95% CI, 1.01-1.04), LTCF residence (HR, 3.23; 95% CI, 1.68-6.20), and quick Sequential Organ Failure Assessment scores (HR, 2.59; 95% CI, 1.78-3.76). Conclusion: In this single-center retrospective cohort study of 313 adult patients hospitalized with COVID-19 illness in a community hospital in Cook County, Illinois, older patients, LTCF residents, and patients with high quick Sequential Organ Failure Assessment scores were found to have worse clinical outcomes and increased risk of death.
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Late treatment
is less effective
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