Medications Associated with Lower Mortality in a SARS-CoV-2 Positive Cohort of 26,508 Veterans
et al., Journal of General Internal Medicine,
Retrospective 26,508 consecutive COVID+ veterans in the USA, showing lower mortality with multiple treatments including colchicine. Treatment was defined as drugs administered ≥50% of the time within 2 weeks post-COVID+, and may be a continuation of prophylactic treatment in some cases, and may be early or late treatment in other cases. Further reduction in mortality was seen with combinations of treatments.
risk of death, 68.0% lower, RR 0.32, p = 0.003, treatment 9 of 402 (2.2%), control 1,603 of 26,106 (6.1%), NNT 26, adjusted per study, day 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hunt et al., 29 Jun 2022, retrospective, USA, peer-reviewed, 8 authors, study period 1 March, 2020 - 10 September, 2020, dosage not specified.